• Thumbnail for Interleukin-17A
    Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8, after the similarity with...
    53 KB (6,247 words) - 19:58, 2 April 2024
  • Thumbnail for Interleukin 17
    Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper...
    35 KB (3,989 words) - 13:32, 13 July 2024
  • of a humanized monoclonal antibody. The substance acts by binding interleukin 17A and neutralizing it, reducing inflammation. The most common side effects...
    16 KB (1,451 words) - 04:45, 6 July 2024
  • Thumbnail for IL17RA
    Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene. Interleukin 17A (IL17A)is a proinflammatory...
    6 KB (855 words) - 11:39, 4 March 2023
  • Thumbnail for Itaconic acid
    investigation.) Interleukin 17 (i.e., IL-17) refers to any one of 6 different but closely related subtypes, IL-17A to IL17F. IL-17A is a pro-inflammatory...
    95 KB (11,779 words) - 04:23, 6 July 2024
  • Thumbnail for Interleukin-17 receptor
    Interleukin-17 receptor (IL-17R) is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory cytokine interleukin 17A, a...
    21 KB (2,139 words) - 19:25, 2 April 2024
  • Thumbnail for Secukinumab
    ankylosing spondylitis, and psoriatic arthritis. It binds to the protein interleukin (IL)-17A and is marketed by Novartis. Secukinumab is used to treat psoriasis...
    15 KB (1,153 words) - 05:27, 18 July 2024
  • Thumbnail for Interleukin 17F
    homologous to interleukin-17A (IL-17A). These two molecules bind to the same receptors and are very likely to have similar biological functions. IL-17A and IL-17F...
    10 KB (1,309 words) - 03:03, 22 May 2024
  • Thumbnail for Psoriasis
    Padova F (October 2010). "Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis". Science Translational...
    115 KB (12,963 words) - 06:07, 26 July 2024
  • Xeligekimab (GR1501) is a monoclonal antibody that neutralizes interleukin-17A; it is being developed for plaque psoriasis, axial spondyloarthritis, and...
    5 KB (272 words) - 23:50, 17 July 2024
  • Thumbnail for Interleukin-1 family
    The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to...
    49 KB (6,005 words) - 16:30, 10 June 2024
  • Thumbnail for Interleukin 22
    Interleukin-22 (IL-22) is a protein that in humans is encoded by the IL22 gene. IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface...
    17 KB (1,945 words) - 13:34, 9 July 2024
  • Thumbnail for Interleukin 19
    Prens E, Florencia E, Leenen P, Boon L, Asmawidjaja P, et al. (2021). "Interleukin-17A Drives IL-19 and IL-24 Expression in Skin Stromal Cells Regulating...
    16 KB (1,943 words) - 08:21, 30 June 2023
  • the cytokine interleukin-4 or eosinophils and is exacerbated by concurrently blocking two cytokines, interferon gamma and interleukin-17A. Finally, certain...
    32 KB (3,618 words) - 03:33, 3 December 2023
  • Thumbnail for STAT1
    polyendocrine syndrome type I. There was reported an interleukin 17A role, because of low levels of IL-17A producing T-cells in CMC patients. With various...
    31 KB (3,702 words) - 10:57, 15 July 2024
  • Thumbnail for Interleukin 23
    Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
    20 KB (2,192 words) - 23:02, 27 November 2023
  • Shimazaki M, Duquette D, Koay HF, et al. (May 2018). "γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis"....
    35 KB (4,472 words) - 00:20, 13 June 2024
  • Beagley, Kenneth; Timms, Peter; Polkinghornea, Adam (October 2014). "Interleukin 17A is an immune marker for chlamydial disease severity and pathogenesis...
    12 KB (1,162 words) - 08:51, 4 December 2023
  • Thumbnail for Type 3 innate lymphoid cells
    Lynde CW, Poulin Y, Vender R, Bourcier M, Khalil S (July 2014). "Interleukin 17A: toward a new understanding of psoriasis pathogenesis". Journal of...
    23 KB (2,835 words) - 01:33, 5 December 2023
  • Thumbnail for Gloria Choi
    Communications. 2016 July 18; doi:10.1038/ncomms12238 The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Gloria...
    26 KB (2,966 words) - 20:54, 29 June 2024
  • Thumbnail for IL17RD
    W, Yang XO, et al. (June 2019). "Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation"...
    10 KB (1,360 words) - 13:56, 17 February 2024
  • Thumbnail for Amphiregulin
    induced by gamma delta (γδ) T cells that produce interleukin 17A (IL-17A). This correlation between IL-17A-producing γδ T cells and amphiregulin has been...
    28 KB (3,296 words) - 18:54, 23 April 2024
  • Thumbnail for Interleukin 25
    Interleukin-25 (IL-25) – also known as interleukin-17E (IL-17E) – is a protein that in humans is encoded by the IL25 gene on chromosome 14. IL-25 was discovered...
    18 KB (2,281 words) - 04:59, 29 April 2024
  • "IL10RA - Interleukin-10 receptor subunit alpha precursor - Homo sapiens (Human)". www.uniprot.org. Retrieved 2015-10-13. "IL10RB - Interleukin-10 receptor...
    96 KB (467 words) - 06:58, 14 October 2022
  • Thumbnail for Free fatty acid receptor 3
    levels of mucus; their lung tissue levels of interleukin-4, interleukin-5, interleukin-13, and interleukin-17A and serum immunoglobulin E levels were elevated;...
    48 KB (6,095 words) - 16:42, 29 June 2024
  • colony-stimulating factors) Interferons (Interferons-α, -β, -γ) Interleukin-based products (Interleukin-2) Vaccines (Hepatitis B surface antigen) Monoclonal antibodies...
    30 KB (2,882 words) - 11:11, 23 July 2024
  • Thumbnail for YWHAZ
    role remains unknown Intracellular 14-3-3ζ plays a role in interleukin-17 signaling. IL-17A is a proinflammatory cytokine involved in autoimmune diseases...
    31 KB (3,619 words) - 23:32, 27 March 2024
  • subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17). They are related to T regulatory cells and the signals that...
    31 KB (3,564 words) - 14:56, 3 December 2023
  • Ustekinumab Interleukin 5 Mepolizumab Immunoglobulin E Omalizumab Interferon Faralimomab IL-6 Elsilimomab IL-12 and IL-23 Lebrikizumab Ustekinumab IL-17A Secukinumab...
    7 KB (299 words) - 13:45, 27 April 2024
  • COVA 322, a bi-specific anti-tumor necrosis factor (TNF)-alpha/anti-interleukin (IL)-17A FynomAb, is in a Phase Ib study for psoriasis. Joos' first discovery...
    3 KB (363 words) - 11:37, 17 February 2023