• Thumbnail for Alternative splicing
    Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single...
    62 KB (7,809 words) - 17:56, 21 May 2024
  • Thumbnail for RNA splicing
    of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur...
    37 KB (4,486 words) - 15:02, 23 July 2024
  • Thumbnail for Primary transcript
    expression. Alternative splicing can be affected by various factors, including mutations such as chromosomal translocation. In prokaryotes, splicing is done...
    23 KB (3,031 words) - 16:33, 24 July 2024
  • Thumbnail for Protein isoform
    Although ~95% of multi-exonic genes are thought to be alternatively spliced, one study on noisy splicing observed that most of the different low-abundance...
    17 KB (2,013 words) - 01:16, 4 January 2024
  • Thumbnail for Serine/arginine-rich splicing factor 1
    Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a...
    21 KB (2,574 words) - 15:07, 31 December 2023
  • Thumbnail for RNA-Seq
    multiple alternative splicing modes: exon skipping (most common splicing mode in humans and higher eukaryotes), mutually exclusive exons, alternative donor...
    103 KB (11,098 words) - 04:11, 29 July 2024
  • Thumbnail for Spinal muscular atrophy
    due to a variation in a single nucleotide (840.C→T) – undergoes alternative splicing at the junction of intron 6 to exon 8, with only 10–20% of SMN2 transcripts...
    89 KB (9,953 words) - 10:33, 25 May 2024
  • structure plots of alternative splicing events from .bam, .gtf, and .vcf files. SpliceR An R package for classification of alternative splicing and prediction...
    164 KB (20,376 words) - 14:18, 16 July 2024
  • Thumbnail for Circular RNA
    examples of alternative splicing is in the Drosophila DSCAM gene, which can give rise to approximately 30 thousand distinct alternatively spliced isoforms...
    55 KB (6,557 words) - 15:18, 12 May 2024
  • still remains an important challenge. As a consequence, the role of alternative splicing in molecular biology remains largely elusive. Third generation sequencing...
    33 KB (3,988 words) - 15:39, 3 April 2024
  • Thumbnail for SR protein
    SR protein (section Splicing)
    and alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA...
    27 KB (3,445 words) - 01:31, 14 June 2024
  • mRNA. Alternative splicing is a mechanism by which different proteins can be produced from a single gene by means of using alternative splicing sites...
    47 KB (5,684 words) - 07:00, 27 July 2024
  • Thumbnail for Alberto Kornblihtt
    is an Argentine molecular biologist who specializes in alternative ribonucleic acid splicing. During his postdoctoral training with Francisco Baralle...
    20 KB (2,229 words) - 18:14, 6 July 2024
  • Thumbnail for Sex-lethal
    female-specific alternative splicing of the transformer (tra) pre-mRNA by binding to the tra uridine-rich polypyrimidine tract at the non-sex-specific 3' splice site...
    4 KB (459 words) - 17:48, 11 September 2022
  • Thumbnail for Tropomyosin
    3-9. Alternative splicing can occur at exon 6, with the mutually exclusive choice of exon 6a or 6b. At the c-terminus, the transcript is spliced again...
    51 KB (6,192 words) - 19:26, 10 May 2024
  • Intron (category RNA splicing)
    relevant, alternative splicing and processing noise due to splicing errors. One of the central issues in the field of alternative splicing is working out the...
    47 KB (5,839 words) - 23:00, 11 July 2024
  • Thumbnail for DNA ligase 3
    encodes several distinct DNA ligase species by alternative translation initiation and alternative splicing mechanisms that are described below. Eukaryotic...
    31 KB (3,833 words) - 18:09, 27 June 2024
  • exclusion during splicing. These sites are referred to as exonic splicing enhancers (ESEs), exonic splicing silencers (ESSs), intronic splicing enhancers (ISEs)...
    39 KB (4,540 words) - 18:39, 20 July 2024
  • Thumbnail for Exon
    Exon (category RNA splicing)
    RNA splicing. The term exon refers to both the DNA sequence within a gene and to the corresponding sequence in RNA transcripts. In RNA splicing, introns...
    13 KB (1,517 words) - 23:39, 2 April 2024
  • Thumbnail for Neuroligin
    alternative splicing, and certain splice variants of neuroligins and neurexins are more selective for one another. Specific pairing of splice variants also...
    22 KB (2,569 words) - 08:15, 13 July 2024
  • Thumbnail for Spliceosome
    Spliceosome (category RNA splicing)
    3'-splice site. All five metals (assigned as Mg2+) in the yeast complex are preserved in the human complex.[citation needed] Alternative splicing (the...
    21 KB (2,635 words) - 23:46, 24 July 2024
  • Thumbnail for Immunoglobulin D
    diverse with amplifications of Cδ exons. Different splice variants exist due to alternative splicing. In humans and primates, IgD has three Cδ domains...
    17 KB (2,096 words) - 15:53, 6 April 2024
  • proteolytic activity of T.A.C.E. In humans, studies have shown that alternative splicing of the GHR gene can lead to increased rates of proteolysis. For example...
    23 KB (2,797 words) - 08:41, 24 August 2023
  • Alternative Splicing Annotation Project (ASAP) in computational biology was a database for alternative splicing data maintained by the University of California...
    2 KB (151 words) - 22:12, 6 February 2022
  • Exitron (category RNA splicing)
    Exitrons (exonic introns) are produced through alternative splicing and have characteristics of both introns and exons, but are described as retained introns...
    10 KB (1,318 words) - 01:49, 28 July 2023
  • Thumbnail for RAGE (receptor)
    has only the extracellular domain. sRAGE is either the product of alternative splicing or the product of proteolytic cleavage of mRAGE. The full receptor...
    19 KB (2,337 words) - 03:47, 26 April 2024
  • Thumbnail for Cell nucleus
    be spliced in multiple ways to produce different mature mRNAs that encode different protein sequences. This process is known as alternative splicing, and...
    87 KB (9,882 words) - 09:54, 26 July 2024
  • Thumbnail for Minigene
    abundance of alternative splicing, which occurs in most human genes, and the specificity in which splicing is carried out in vivo. Splicing is distinctly...
    21 KB (2,427 words) - 08:41, 10 March 2024
  • transcripts are spliced together to form a chimeric mRNA. Alternative trans-splicing includes intragenic trans-splicing and intergenic trans-splicing. Intragenic...
    12 KB (1,369 words) - 12:07, 22 February 2024
  • Thumbnail for Doublesex
    gene is expressed in both male and female flies and is subject to alternative splicing, producing the protein isoforms dsxf in females and the longer dsxm...
    3 KB (283 words) - 03:01, 31 October 2023