Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the...

proteins have been identified. The three homologues, called cyclin D1, cyclin D2, and cyclin D3 are expressed in most proliferating cells and the relative...

Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). Cyclins were originally...

of a protein kinase, cyclin-dependent kinase (CDK), with a regulatory subunit, cyclin. Once cyclin-dependent kinases bind to cyclin, the formed complex...

surrounds normal germinal center follicles. MCL cells generally over-express cyclin D1 due to the t(11:14) translocation, a chromosomal translocation in the...

cancer. Cyclin D1 is a protein requisite for cell cycle progression and has been shown to be up-regulated in epithelioid sarcoma. Cyclin D1 is a regulator...

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the...

The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine...

lymphoma, the other protein in the fusion is c-myc (on chromosome 8) and cyclin D1 (on chromosome 11), respectively, which gives the fusion protein pro-proliferative...

downregulate cyclin D1, a cyclin-dependent kinase, if they are not stimulated by the presence of mitogens. In the presence of mitogens, sufficient cyclin D1 can...

usually negative. Cyclin D1 and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 < 4.20%, CK 5/6 positive)...

repression of the D1 cyclin. Both MyoD and pRb are necessary for the repression of cyclin D1, but rather than acting directly on cyclin D1, they act on Fra-1...

phase-specific cyclins beyond just G2 - for instance, destruction of cyclin D1 mRNA by antisense oligonucleotides prevents progression from G1 phase...

"Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene". J. Biol. Chem. 267 (28):...

G1 cyclin, cyclin D1. Myc also regulates expression of a wide variety of pro-proliferative and pro-growth genes, including some induction of cyclin D2...

p53 protein and low levels of Cyclin D1 transcripts were shown to primarily enter G0 whereas cells with high Cyclin D1 and low levels of p53 are most...

Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. The protein...

lymphoma. Mantle cell lymphoma is excluded due to the lack of CD5 and cyclin-D1 expression. Clonal rearrangements of the immunoglobulin genes (heavy and...

damage. Parathyroid adenoma can be associated with overexpression of the cyclin D1 gene. It is also associated with multiple endocrine neoplasia (MEN). Hyperparathyroidism...

spleen and GI tract, associated with t(11;14) translocation overexpressing cyclin D1, moderately aggressive Diffuse large B-cell lymphoma, not otherwise specified...

immunoprecipitate with active cyclin D-CDK4 complexes. Futhurmore, mouse embryonic fibroblasts deficient for p21 and p27 had lower levels of cyclin D1 and immunoprecipitated...

phosphorylation and degradation of cyclin D1. Therefore, Akt promotes G1 phase progression in a positive feedback loop. Akt promotes cyclin D1 translation via indirect...

encoded by the CDK6 gene. It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. The protein...

(ERK), AP-1, and NF-κB. Also, the mitotic regulator for G1 progression, cyclin D1 was found to be activated. Although there was no increase in any isoform...

"The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2". The EMBO Journal. 15 (24): 7060–9...

The ERK1/2 pathway also phosphorylates NF-κB causing an upregulation of cyclin D1, a G1 phase regulator protein. When NNK is present it directly involves...

cases) and CD5 (~20% of cases) marker proteins but do not express the cyclin D1 marker protein., the T-cell marker, CD10, or BCL6. There are various EMZL...

of AIF-1 enhanced activity of NF-ΚB and increased expression of cyclin D1. Cyclin D1 contribute to cell proliferation and mutation in this gene has been...

(August 2001). "Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes". Molecular Biology of the Cell. 12 (8): 2352–63...

fibroblasts and neuronal cells by direct inhibition of the activity of cyclin D1 promoter. A number of studies in vivo have shown that BTG2 expression...