The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory...

GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptors including...

In pharmacology, GABAA receptor positive allosteric modulators, also known as GABAkines or GABAA receptor potentiators, are positive allosteric modulator...

of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled...

and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil. Other agents which may have GABAA receptor antagonism include the antibiotic ciprofloxacin...

effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety)...

GABAA receptor agonist of the imidazopyridine class. It works by increasing GABA effects in the central nervous system by binding to GABAA receptors at...

mushroom. Muscimol is a potent and selective orthosteric agonist for the GABAA receptor and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity...

classes of GABA receptor are known: GABAA in which the receptor is part of a ligand-gated ion channel complex GABAB metabotropic receptors, which are G protein-coupled...

electrical activity of neurons by binding to GABAA receptors. There are three main ways the action of the receptor can be classified: relay of signal, amplification...

GABAA receptor channel is only one of several representatives. This Cys-loop receptor superfamily of ion channels includes the neuronal nACh receptor...

outdated with time. EVT-201 – GABAA receptor positive allosteric modulator[1] Lorediplon (GF-015535-00) – GABAA receptor positive allosteric modulator...

A GABAA receptor negative allosteric modulator is a negative allosteric modulator (NAM), or inhibitor, of the GABAA receptor, a ligand-gated ion channel...

is a neurosteroid and acts as a positive allosteric modulator of the GABAA receptor, the major biological target of the inhibitory neurotransmitter γ-aminobutyric...

antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate receptor agonists. Many other drugs may cause convulsions...

dorsal root ganglion neurons despite the presence of GABAA receptors. Glycine and its receptor were first suggested to play a role in inhibition of cells...

stanozolol, and methyltestosterone, have been found to modulate the GABAA receptor similarly to endogenous neurosteroids like allopregnanolone, 3α-androstanediol...

believed to act as an NMDA receptor antagonist and positive allosteric modulator of GABAA receptors. Its activity on those receptors is indirect, unlike that...

transmission to reduce anxiety. The GABAA receptor is made up of 5 subunits out of a possible 19, and GABAA receptors made up of different combinations...

believed to be GABAA receptor, with particular β subunits playing a crucial role. The concept of specific interactions between receptors and drugs first...

and include: GABAA receptors GABAA-ρ receptors The GABAB receptor, a G protein-coupled receptor, is the only metabotropic GABA receptor and its mechanism...

17β-diol – GABAA receptor positive allosteric modulator 3α,5β-Androstanediol (etiocholanediol): 5β-androstane-3α,17β-diol – GABAA receptor positive allosteric...

Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective GABAA receptor antagonist administered via injection, otic insertion, or intranasally...

mediate their effects: GABAA receptors are chloride channels that hyperpolarize neurons and function as inhibitory CNS receptors. General anesthetics that...

that contain this same chemical substructure. In general, they are GABAA receptor agonists, however recently proton pump inhibitors, aromatase inhibitors...

positive allosteric modulators of the GABA type A receptors (GABAA). The GABAA receptors are ligand-gated chloride-selective ion channels that are activated...

phthalide-isoquinoline compound that is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and...

has been shown to affect ligand-gated ion channels, particularly the GABAA receptor. After oral ingestion, ethanol is absorbed via the stomach and intestines...

mechanisms of action, both through potentiation of GABAA receptor activity and therefore acting as a GABAA receptor positive allosteric modulator, thereby slowing...

acid) – constituent of valerian; has anticonvulsant effects; PAM of the GABAA receptor Derivatives: isovalerate (isopentanoate/3-methylbutanoate), menthyl...