glutamate hypothesis of schizophrenia models the subset of pathologic mechanisms of schizophrenia linked to glutamatergic signaling. The hypothesis was...

dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a disturbed...

also be responsible for deficits in working memory. The glutamate hypothesis of schizophrenia links alterations between glutamatergic neurotransmission...

understood. A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link...

further brain development, glutamate receptors broke down. This theory supports the glutamate hypothesis of schizophrenia. Another study in 2009 by Simon...

schizophrenia. They claim these results are consistent with the glutamate hypothesis of schizophrenia, which proposes that dysfunction in this neurotransmitter...

aging. Schizophrenia may also have to do with irregular NMDA receptor function (the glutamate hypothesis of schizophrenia). Increased levels of another...

wider range of symptoms that resemble schizophrenia in healthy volunteers, in what has led to the glutamate hypothesis of schizophrenia. Experiments...

onset of catatonia can be acute or subtle and symptoms can wax, wane, or change during episodes. It has historically been related to schizophrenia (catatonic...

varying levels of gliotransmission and calcium excitability. One theory, called the glutamate hypothesis of schizophrenia, suggests that glutamate deficiency...

supports the hypo-glutamatergic neurotransmission hypothesis in schizophrenia. The release of glutamate by system Xc- may lead to excitotoxicity, which...

agonist action of mGluR2/3 agonists at D2 receptors were unsuccessful. Based on the glutamate hypothesis of schizophrenia, glutamate receptor agonists...

diagnosis of schizophrenia, a psychotic disorder, is based on criteria in either the American Psychiatric Association's Diagnostic and Statistical Manual of Mental...

dopamine activity and NMDArs, thus linking dopamine hypothesis of schizophrenia with the glutamate hypothesis of the disease. Kynurenic acid is reduced in individuals...

Evidence for the involvement of glutamate in schizophrenia includes analogous symptoms which are produced by glutamate NMDA receptor antagonists such...

Javitt D (January 2012). "From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment". Neuropsychopharmacology...

Tandon R, Copolov D, Dean B (March 2007). "Towards a muscarinic hypothesis of schizophrenia". Molecular Psychiatry. 12 (3): 232–246. doi:10.1038/sj.mp.4001924...

a glutamate–glutamine cycle, which results in reuptake of glutamate from the synapse into the pre-synaptic cell to be recycled, keeping glutamate from...

antipsychotic) to be discovered. It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to...

2018). "Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: dopamine, serotonin, and glutamate". CNS Spectrums. 23 (3):...

Huang, XF (Aug 22, 2005). "Ionotropic glutamate receptor binding in the posterior cingulate cortex in schizophrenia patients". NeuroReport. 16 (12): 1363–7...

protein GAD67, an enzyme that catalyzes the formation of GABA from glutamate. Individuals with schizophrenia have shown a decrease in GAD67 levels and this deficit...

received regulatory approval (e.g. by the FDA of the US, the TGA of Australia, the MHRA of the UK) for schizophrenia, bipolar disorder, irritability in autism...

Schizophrenia Research Foundation (SCARF) was founded in 1984 with the primary objective of providing quality care and rehabilitation to those suffering...

sedative–hypnotic drugs causes chronic GABA receptor downregulation as well as glutamate overactivity, which can lead to drug and neurotransmitter sensitization...

expression of GAD-67 enzyme, which catalyses the transition of glutamate to GABA. Blood levels of reelin and its isoforms are also altered in schizophrenia, along...

psychiatry for treating alcoholism and schizophrenia. However, its association with the counterculture movement of the 1960s led to its classification as...

studied glutamate's excitatory effects on the brain along with the role this neurotransmitter plays in common mental illnesses, primarily in schizophrenia. A...

basis of hallucinations has been explored on the cellular receptor level. The glutamate hypothesis, proposed as a possible cause for schizophrenia, may...

decreasing the glutamate in the brain, alcohol increases the amount of the chemical dopamine in the brain, which is one of the addictive causes of alcoholism...