Potassium voltage-gated channel subfamily A member 1 also known as Kv1.1 is a shaker related voltage-gated potassium channel that in humans is encoded...
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Tomb KV1, located in the Valley of the Kings in Egypt, was used for the burial of Pharaoh Ramesses VII of the Twentieth Dynasty. Although it has been...
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Episodic ataxia (redirect from Episodic Ataxia Type-1)
encodes the voltage-gated potassium channel KV1.1, are responsible for this subtype of episodic ataxia. KV1.1 is expressed heavily in basket cells and interneurons...
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potassium channel Kv1.1 with no effect on other tested potassium channels (Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6, Shaker IR, Kv2.1, Kv3.1, Kv4.2 and Kv4.3)...
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sonata by Domenico Scarlatti KV-1, the first model of the Kliment Voroshilov tank, deployed by the Soviets in World War II KV1, the tomb of Pharaoh Ramesses...
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BgK blocks the Kv1.1, Kv1.2, and Kv1.3 channels with similar affinities. IC50 is 6 nM for Kv1.1, 15 nM for Kv1.2, and 10 nM for Kv1.3. Meanwhile, tests...
9 KB (1,107 words) - 15:58, 30 March 2024
channels (IK) Several types of voltage-gated potassium channels (Kv1.1, Kv1.2, Kv1.3 and shaker B) The structural and pharmacological features of MTX...
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Margatoxin (MgTX) is a peptide that selectively inhibits Kv1.3 voltage-dependent potassium channels. It is found in the venom of Centruroides margaritatus...
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example, Wang et al. showed that the interaction of dendrotoxin-K with KV1.1 is mediated by its lysine residues in both the N-terminus and the β-turn...
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Shaker-type (Kv1) K+ channels. HgTX1 shows high affinity with Kv1.1, Kv1.2, Kv1.3 voltage-gated potassium channels, but much lower affinity with Kv1.6 (see...
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Amitriptyline (category Alpha-1 blockers)
MA, Friederich P (May 2007). "Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels". Anesthesia and Analgesia. 104 (5): 1256–64, tables...
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Iranian scorpion Hemiscorpius lepturus, which reversibly blocks Kv1.1, Kv1.2 and Kv1.3 voltage-gated K+ channels. HTX is a neurotoxin derived from the...
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eupeus. This short-chain peptide blocks potassium channels, such as Kv1.1, Kv1.2 and Kv1.3. MeuKTX is a neurotoxin found in the venom of the scorpion Mesobuthus...
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Pandinus imperator toxin (Pi4) (section Kv1.2 channel)
Kv1.2, and SK potassium channels. Pi4 binds to Shaker B potassium channels, the Drosophila homologue of the voltage-gated potassium channel Kv1.1. Pi4...
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KCNA2 (redirect from Kv1.2 potassium channel)
Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene. Potassium channels...
12 KB (1,518 words) - 22:32, 16 July 2024
rapidly inactivating (KV1.4 and KV3.4) or delayed rectifier potassium channels (KV1.1, KV1.2, KV1.3, KV1.5, KV1.6, KV1.2/ KV1.5, or KVLQT1), or on sodium...
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stigmurus, a species of Brazilian scorpion. Tst26 selectively blocks Kv1.2 and Kv1.3 channels. Tst26 is named after the species it was discovered from...
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Valerie B O'Leary, Christian Leibold, J Oliver Dolly. "Distinctive role of KV1.1 subunit in the biology and functions of low threshold K+ channels with implications...
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(K+) ion channels Kv1.1, Kv1.3, Kv1.6, Kv3.2 and KCa3.1 with nanomolar to picomolar potency, and has no effect on the HERG (Kv11.1) cardiac potassium...
74 KB (8,628 words) - 07:57, 22 June 2024
Shaker-related: Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), Kv1.8 (KCNA10) Kvα2.x - Shab-related: Kv2.1 (KCNB1)...
17 KB (1,769 words) - 15:18, 22 June 2024
ImKTx88 is a selective inhibitor of the Kv1 ion channel family that can be isolated from the venom of the Isometrus maculatus (lesser brown scorpion)...
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channels. The dissociation constants (Kd) for Kv1.1, Kv1.2 and Kv1.3 channels are, respectively, 21.1 μM, 1.0 μM and 0.8 μM in the case of PBTx1 and 79...
5 KB (675 words) - 09:53, 9 September 2023
KCNA5 (redirect from Kv1.5 potassium channel)
voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the KCNA5 gene. Potassium channels...
12 KB (1,484 words) - 00:45, 17 July 2024
voltage gated sodium channels (Nav). The toxins' main targets are Kv1.1 (IC50 = 46 μM) and Kv1.4 (IC50 = 71 μM), showing a low affinity for Kv channels overall...
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channels present: Kv1.1, Kv1.2, Kv1.3, and Kv7.5. Kv1.1 and Kv1.2 are located in the transition zone between the axon and the terminal, while Kv1.3 Kv7.5 are...
25 KB (3,090 words) - 19:43, 7 August 2024
Palmitoyl acyltransferase (category EC 2.3.1)
receptor subunit GluR1 and GluR2, GABAA receptor gamma2 subunit, aquaporin, KV1.1, rhodopsin, beta2-adrenergic receptor, and PSD-95. https://swisspalm.org/enzymes...
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Shaker-related: Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), Kv1.8 (KCNA10) Kvα2.x - Shab-related: Kv2.1 (KCNB1)...
19 KB (1,692 words) - 03:53, 29 November 2023
especially Kv1.1-1.5 channels and the Kv3.1 channel. Kv1.1-1.5 channels are responsible for repolarization of the membrane potential. The Kv1.3 channel...
22 KB (2,188 words) - 10:30, 22 March 2024