Microglia are a type of glial cell located throughout the brain and spinal cord of the central nervous system (CNS). Microglia account for about 10–15%...

Microglia are the primary immune cells of the central nervous system, similar to peripheral macrophages. They respond to pathogens and injury by changing...

oligodendrocytes (that produce myelin), astrocytes, ependymal cells and microglia, and in the peripheral nervous system they include Schwann cells (that...

hypertrophy of several different types of glial cells, including astrocytes, microglia, and oligodendrocytes. In its most extreme form, the proliferation associated...

the central nervous system (CNS), including the brain and spinal cord, microglia are the resident innate immune cells that are activated in response to...

such as monocytes, macrophages, osteoclasts, myeloid dendritic cells, microglia, and Paneth cells. CSF1R expression is controlled by two alternative promoters...

these extrinsic cues for microglia and microglia themselves may produce proteins that amplify the response. The effect of microglia on neurons that leads...

pancreatic stellate cells, dendritic cells, oligodendrocytes, and others. Microglia, which are notably smaller than macroglia, can also extend their end-processes...

productive cytotoxic effector cells that are capable of lysing tumor cells Microglia, a glial effector cell that reconstructs the Central nervous system after...

at Boston Children’s Hospital. She has helped to identify the role of microglia and complement proteins in the "pruning" or removal of synaptic cells...

have also been linked to allodynia. For example, there are reports that microglia in the thalamus might contribute to allodynia by changing the properties...

ATP has been shown to be a critically important signalling molecule for microglia - neuron interactions in the adult brain, as well as during brain development...

causes of a cytokine storm. The cells of the central nervous system, the microglia, neurons, and astrocytes, are also involved in the release of pro-inflammatory...

matter of the brain. Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques. Some plaques occur...

–astrocytes, ependymal cells, and oligodendrocytes, and much smaller microglia which are the macrophages of the central nervous system. Astrocytes are...

disorders. Within the brain, quinolinic acid is only produced by activated microglia and macrophages. In 1949 L. Henderson was one of the earliest to describe...

healthy controls, suggesting upregulated microglia-induced synaptic pruning in these individuals. Microglia-mediated synaptic pruning has also been observed...

function. Neuroglial cells are classified as follows: Microglial cells: Microglia are macrophage cells that make up the primary immune system for the CNS...

nervous system, this receptor has been found expressed exclusively on microglia, where it is necessary for physiological and pathological microglial actions...

expression of glial and immune cells in the brain, e.g. astrocytes and microglia, respectively, are overexpressed, which correlates with increased number...

sarcopenia, and aging-associated diseases. Senescent astrocytes and microglia contribute to neurodegeneration. Mechanistically, replicative senescence...

3D animation of Müller cell processes (red) interconnected with a retinal microglia cell (green)....

expressed in macrophages / microglia and is upregulated during the activation of these cells. Iba1 expression is up-regulated in microglia following nerve injury...

cells, (2) analysis of the degradation of Alzheimer's amyloid plaque by microglia, and (3) development of novel therapies for Niemann-Pick C disease. Notable...

of pathogenic tau protein acetylation in tauopathies and mechanisms of microglia dysfunction in neurodegeneration. Gan attended Peking University from...

antibodies against CD11B is frequently used to identify macrophages and microglia. CD11b, as an integrin molecule on the surface of leukocytes, plays an...

induced by HIV infection and fueled by immune activation of macrophages and microglia. These cells are actively infected with HIV and secrete neurotoxins of...

anti-inflammatory states, microglia have also been shown to be able to assist in remyelination & subsequent neuron repair. As such, microglia are thought to be...

response in microglia and can cause neuroinflammation. SSRIs inhibit proinflammatory cytokine production which leads to less activation of microglia and peripheral...

circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia). Human CD68 is a Type I transmembrane glycoprotein, heavily glycosylated...