kinase 1 (RIPK1) functions in a variety of cellular pathways related to both cell survival and death. In terms of cell death, RIPK1 plays a role in...

TRADD and can activate caspase 8 without RIPK1, while complex IIb does not include TRADD, so it is dependent on RIPK1 for the activation of caspase 8. The...

death protein TRADD and TNF receptor-associated factor 2 TRAF2 signals to RIPK1 which recruits RIPK3 forming the necrosome also named ripoptosome. Phosphorylation...

conditions, and cancer. Several PANoptosome complexes, such as the ZBP1-, AIM2-, RIPK1-, and NLRC5- and NLRP12-PANoptosomes, have been characterized so far. Emerging...

between Ciudad Real and Puertollano CRIA syndrome (Cleavage-resistant RIPK1-induced autoinflammatory syndrome), a medical disorder This disambiguation...

response to autocrine TNFα signaling, the Smac mimetic promotes formation of a RIPK1-dependent caspase-8-activating complex, leading to apoptosis. Recent studies...

necroptosis by interaction with RIPK1 and MLKL in a protein complex termed the necrosome. Interactions between RIPK1 and RIPK3 also form a necrosome,...

serine/threonine protein kinases. In humans, five different RIP kinases are known: RIPK1 RIPK2 RIPK3 RIPK4 RIPK5 Zhang, Duanwu; Lin, Juan; Han, Jiahuai (July 2010)...

triggers: The ZBP1-PANoptosome responds to influenza virus infection The RIPK1-PANoptosome responds to Yersinia infection and the inhibition of transforming...

receptor, recruiting the adaptor TRIF. TRIF activates the kinases TBK1 and RIPK1, which creates a branch in the signaling pathway. The TRIF/TBK1 signaling...

O14730 13784 RIOX1 HGNC:20968 Q9H6W3 13785 RIOX2 HGNC:19441 Q8IUF8 13786 RIPK1 HGNC:10019 Q13546 13787 RIPK2 HGNC:10020 O43353 13788 RIPK3 HGNC:10021 Q9Y572...

necroptosis via RIPK1, FADD, RIPK3, and MLKL, ferroptosis via GPX4 suppression, system Xc suppression, and NAPDH loss, as well as apoptosis via RIPK1 and caspase...

ATG12, Caspase 8 and RIPK1. The formation of this complex is stimulated by autophagic signalling. Caspase 8 then cleaves RIPK1, leading to inhibition...

the one found in human receptor-interacting serine/threonine kinase 1 (RIPK1, also known as RIP1), discovered a protein and named it LRDD based on its...

also an essential component of several PANoptosomes, including the ZBP1-, RIPK1-, and NLRP12-PANoptosome. NLRC4 is the only member of the NLRC family currently...

interactions with other proteins. Experiments showed that ZBP1 interacts with RIPK1 and RIPK3 through these RHIM domains. This interaction hinted at ZBP1's...

Sequestosome 1 has been shown to interact with: MAP1LC3A, PRKCI, RAD23A, RIPK1, TRAF6 TrkA, and TrkB. Nrf2 ENSG00000284099 GRCh38: Ensembl release 89:...

the AIM2 inflammasome further interacts with caspase-8, FADD, RIPK3, and RIPK1 in response to specific pathogens, including Francisella novicida and herpes...

Caspase-6, Caspase-7, Caspase-9, DEDD, FADD, FasL, FasR, IFT57, NOL3, PEA15, RIPK1, TNFRSF10B, and TRAF1. Biology portal Caspase FADD The Proteolysis Map GRCh38:...

same terminal event of karyolysis but within a programmed framework. The RIPK1-RIPK3-MLKL signaling axis directs the process, ensuring controlled steps...

to interact with: BAG4, CASP10, FADD, IKK2, JAK1, JAK2, PIP4K2B, PSMD2, RIPK1, SUMO1, TRADD TRAF2, TRPC4AP, TNF, and UBE2I. Cluster of differentiation...

potential role for necrostatin-1 in stroke treatment. Her group then identified RIPK1 as the target for necrostatin-1, thus implicating it as a key player in...

PTK2 ; PTK2B ; PTK6 ; PTK7 ; PXK ; RAF1 ; RET ; RIOK1 ; RIOK2 ; RIOK3 ; RIPK1 ; RIPK2 ; RIPK3 ; RIPK4 ; RNASEL ; ROCK1 ; ROCK2 ; ROR1 ; ROR2 ; ROS1 ;...

kinases. The most notable among these being CAMK2G, CAMK2D, ERK/Akt, and RIPK1. CAMK2G and CAMK2D belong to the same calcium/calmodulin dependent protein...

receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. CRADD has been shown to interact with RIPK1 and Caspase 2. GRCh38:...

death pathway. TRADD has been shown to interact with: FADD, Keratin 18 RIPK1, STAT1, TNFRSF1A, TNFRSF25, and TRAF2. TRAF RIP GRCh38: Ensembl release...

complex molecular mechanisms that regulate activity of caspase-8, OTULIN, RIPK1, RIPK3 and other proteins that modulate inflammation, apoptosis and necroptosis...

pathways such as oxidative stress and receptor-interacting protein kinase 1 (RIPK1) kinase activity-dependent pathway. In response to IL-1, this protein forms...

IAP repeat-containing protein 3 has been shown to interact with: CASP9, RIPK1, TRAF1, TRAF2, and UBE2D2. GRCh38: Ensembl release 89: ENSG00000023445 –...

Janke, L. J.; Kelliher, M. A.; Kanneganti, T. D.; Green, D. R. (2014). "RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3". Cell...