Aptamers are oligomers of artificial ssDNA, RNA, XNA, or peptide that bind a specific target molecule, or family of target molecules. They exhibit a range...

Aptamers, single-stranded RNA and DNA sequences, bind to an analyte and change their conformation. They function as nucleic acids selectively binding molecules...

synthetically derived RNA aptamer born out of the need for a way of studying the role of RNAs at the cellular level. This aptamer was created using Systematic...

Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA, was...

messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), and RNA aptamers. Of the four types, mRNA-based therapy is the only type which is based...

ligands. These single-stranded DNA or RNA are commonly referred to as aptamers. Although SELEX has emerged as the most commonly used name for the procedure...

immuno-RCA, the ssDNA RCA primer can be conjugated to the 3' end of a DNA aptamer as well. The primer tail can be amplified through rolling circle amplification...

international nonproprietary name is Rovunaptabin, is an oligonucleotide aptamer, a synthetic DNA compound designed to bind other chemicals. BC-007 is in...

pair to DNA aptamer generation by in vitro selection (SELEX) and demonstrated the genetic alphabet expansion significantly augment DNA aptamer affinities...

Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed. Smart ligands can find a set...

green. For example, Zhao et al., demonstrated the use of malachite green aptamer in microcantilever based sensors to detect low concentration of malachite...

An L-ribonucleic acid aptamer (L-RNA aptamer, trade name Spiegelmer) is an RNA-like molecule built from L-ribose units. It is an artificial oligonucleotide...

increased scalability and consistency in manufacture compared to standard aptamer molecules. Optimer ligands are composed of single-stranded DNA or RNA polymers...

alongside Paul Weiss and Anne M. Andrews. Her doctoral research considered aptamer-functionalised field effect transistors for serotonin and dopamine sensing...

important for aptamer generation. Citartan, Marimuthu; et al. (December 2011). "Asymmetric PCR for good quality ssDNA generation towards DNA aptamer production"...

Melting: A Love Story 2010 Chemistry Maureen McKeague Selection of a DNA Aptamer for Homocysteine using SELEX 2009 Graduate Student Sue Lynn Lau The Role...

and streptavidin proteins. DNA and other nucleic acids are the basis of aptamers, synthetic oligonucleotide ligands for specific target molecules used in...

IL-1α and the aptamer. Huang et al. uses ACE to investigate protein-protein interactions using aptamers. A α-thrombin binding aptamer was labeled with...

12-dimethylbenzanthracene), a mutagen. Moreover, HSF1 inhibition by a potent RNA aptamer attenuates mitogenic (MAPK) signaling and induces cancer cell apoptosis...

2014). "Intracellular gene transcription factor protein-guided MRI by DNA aptamers in vivo". FASEB Journal. 28 (1): 464–73. doi:10.1096/fj.13-234229. PMC 3868842...

ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...

known different activity depending on enantiomeric form, Aptamers (L-ribonucleic acid aptamers): "That makes mirror-image biochemistry a potentially lucrative...

specifically bind antigens. They consist of artificial peptides or proteins, or aptamer-based nucleic acid molecules with a molar mass of about 3 to 20 kDa. Antibody...

and loratadine, various immune-modulating drugs, and the experimental aptamer compound BC-007 (Rovunaptabin). In 2021, the US National Institutes of...

an aptamer rather than an antibody. This could be seen as similar to a Southern blot, however the interaction is between a DNA molecule (the aptamer) and...

Novartis purchased the rights to market Ophthotech's Fovista (an anti-PDGF aptamer, also being investigated for use in combination with anti-VEGF treatments)...

usually consist of two metabolite-binding aptamer domains with similar structures in tandem. The aptamers were originally thought to cooperatively bind...

ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...

materials used in sensor development are molecularly imprinted polymers and aptamers. A chemical sensor array is a sensor architecture with multiple sensor...

Sensitivity of Label Free Microcantilever Based Biosensor Using Malachite Green Aptamer". Sensors and Actuators B: Chemical. 300. doi:10.1016/j.snb.2019.126963...