CRISPR (/ˈkrɪspər/) (an acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic...
128 KB (13,448 words) - 03:26, 19 August 2024
CRISPR gene editing (CRISPR, pronounced /ˈkrɪspər/ "crisper", refers to "clustered regularly interspaced short palindromic repeats") is a genetic engineering...
170 KB (19,936 words) - 11:24, 2 September 2024
CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug, Switzerland. It was one of the first companies formed to utilize...
11 KB (918 words) - 14:13, 19 April 2024
Cas9 (redirect from CRISPR/Cas9)
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense...
43 KB (5,610 words) - 21:17, 2 May 2024
February 19, 1964) is an American biochemist who has pioneered work in CRISPR gene editing, and made other fundamental contributions in biochemistry and...
66 KB (5,701 words) - 19:12, 9 September 2024
CRISPR-Display (CRISP-Disp) is a modification of the CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats) system for genome editing...
16 KB (2,133 words) - 12:04, 22 March 2024
CRISPR RNA or crRNA is a RNA transcript from the CRISPR locus. CRISPR-Cas (clustered, regularly interspaced short palindromic repeats - CRISPR associated...
10 KB (1,149 words) - 06:02, 17 June 2024
CRISPR activation (CRISPRa) is a type of CRISPR tool that uses modified versions of CRISPR effectors without endonuclease activity, with added transcriptional...
21 KB (2,672 words) - 09:24, 16 August 2024
Anti-CRISPR (Anti-Clustered Regularly Interspaced Short Palindromic Repeats or Acr) is a group of proteins found in phages, that inhibit the normal activity...
32 KB (3,691 words) - 06:48, 24 August 2024
He Jiankui affair (redirect from CRISPR baby)
standard in vitro fertilisation services and in addition, use of CRISPR gene editing (CRISPR/Cas9), a technology for modifying DNA. The embryos' genomes were...
103 KB (11,578 words) - 14:28, 2 September 2024
CRISPR interference (CRISPRi) is a genetic perturbation technique that allows for sequence-specific repression of gene expression in prokaryotic and eukaryotic...
24 KB (2,898 words) - 12:08, 22 March 2024
(gRNAs) for use with the CRISPR/Cas gene editing system. The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR associated nucleases)...
16 KB (1,283 words) - 11:02, 29 August 2024
Genome-wide CRISPR-Cas9 knockout screens aim to elucidate the relationship between genotype and phenotype by ablating gene expression on a genome-wide...
55 KB (6,164 words) - 23:47, 3 December 2023
The CRISPR Journal is a peer-reviewed scientific journal published every three months by Mary Ann Liebert. It covers research on all aspects of CRISPR research...
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Cas12a (redirect from CRISPR/Cas12a)
(CRISPR-associated protein 12a, previously known as Cpf1) is a subtype of Cas12 proteins and an RNA-guided endonuclease that forms part of the CRISPR system...
13 KB (1,530 words) - 21:01, 18 August 2024
thereby preventing the CRISPR locus from being targeted and destroyed by the CRISPR-associated nuclease. In a bacterial genome, CRISPR loci contain "spacers"...
12 KB (1,421 words) - 00:22, 14 December 2022
Emmanuelle Charpentier (section CRISPR/Cas9)
Chemistry "for the development of a method for genome editing" (through CRISPR). This was the first science Nobel Prize ever won by two women only. Born...
43 KB (3,302 words) - 19:19, 9 September 2024
diagnostic tests using CRISPR-Cas12a and CRISPR-based therapies using its proprietary ultra-small CRISPR systems. Several CRISPR-Cas systems identified...
7 KB (685 words) - 06:53, 23 April 2024
Guide RNA (section CRISPR In Prokaryotes)
used for gene editing. In bacteria and archaea, gRNAs are a part of the CRISPR-Cas system that serves as an adaptive immune defense that protects the organism...
30 KB (3,628 words) - 15:29, 5 August 2024
Genome editing (section CRISPR)
meganucleases—were selected by Nature Methods as the 2011 Method of the Year. The CRISPR-Cas system was selected by Science as 2015 Breakthrough of the Year. As...
78 KB (9,362 words) - 13:30, 27 July 2024
Francisco Mojica (section The discovery of CRISPR)
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). These were later developed into the first widespread genome editing tool, CRISPR-Cas9...
20 KB (1,955 words) - 15:49, 15 October 2023
CRISPR-associated transposons or CASTs are mobile genetic elements (MGEs) that have evolved to make use of minimal CRISPR systems for RNA-guided transposition...
14 KB (1,712 words) - 03:10, 1 July 2024
technologies such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9), are also improving the nutrition, taste and yield of crops. There...
32 KB (3,576 words) - 19:10, 19 August 2024
Designer baby (section CRISPR/Cas9)
homology directed repair. The CRISPR/Cas9 system (CRISPR – Clustered Regularly Interspaced Short Palindromic Repeats, Cas9 – CRISPR-associated protein 9) is...
71 KB (8,210 words) - 14:25, 2 September 2024
in Texas on protein evolution, including that of CRISPR, He learned gene-editing techniques (CRISPR/Cas9) as a postdoctoral researcher at Stanford University...
61 KB (6,078 words) - 06:55, 14 August 2024
on pooled genetic perturbation screens. Perturb-seq combines multiplexed CRISPR mediated gene inactivations with single cell RNA sequencing to assess comprehensive...
21 KB (2,588 words) - 18:53, 19 April 2024
Germline mutation (section CRISPR/Cas9 editing)
initiates cellular repair processes, similar to that of CRISPR/Cas9 DNA editing. Compared to CRISPR/Cas9, the therapeutic applications of this technology...
25 KB (3,085 words) - 14:19, 5 August 2024
Gene drive (section CRISPR)
organism's DNA along with the CRISPR-Cas9 machinery. When the modified organism mates and its DNA mixes with that of its mate, the CRISPR-Cas9 tool cuts the partner's...
47 KB (5,127 words) - 10:04, 8 June 2024
Human Nature (2019 film) (redirect from CRISPR (film documentary))
Kirschner and Dan Rather. The film describes the gene editing process of CRISPR (an acronym for "Clustered Regularly Interspaced Short Palindromic Repeats")...
9 KB (828 words) - 13:11, 27 June 2024
Human genetic enhancement (section CRISPR/Cas9)
benefits of revolutionary tools like CRISPR are endless. For example, because it can be applied directly in the embryo, CRISPR/Cas9 reduces the time required...
95 KB (10,491 words) - 11:26, 7 September 2024