DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during...
35 KB (4,179 words) - 16:38, 9 May 2024
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both...
128 KB (15,837 words) - 04:28, 8 July 2024
MLH1 (section Role in DNA mismatch repair)
DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. The gene is...
28 KB (3,414 words) - 10:03, 27 March 2024
MSH2 (section Role in mismatch repair)
DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome...
35 KB (4,241 words) - 03:25, 27 June 2024
Mismatch repair cancer syndrome (MMRCS) is a cancer syndrome associated with biallelic DNA mismatch repair mutations. It is also known as Turcot syndrome...
7 KB (622 words) - 01:36, 11 March 2023
enzyme action. Nicks allow DNA strands to untwist during replication, and are also thought to play a role in the DNA mismatch repair mechanisms that fix errors...
16 KB (2,041 words) - 14:01, 2 July 2024
is involved in DNA mismatch repair. The protein forms a heterodimer with MLH1 and this complex interacts with MSH2 bound to mismatched bases. Defects...
27 KB (3,253 words) - 20:40, 11 June 2024
excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR)...
33 KB (3,620 words) - 16:53, 6 April 2024
MSH6 (section Importance of mismatch repair)
MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of...
23 KB (2,942 words) - 20:15, 5 April 2024
Hereditary nonpolyposis colorectal cancer (category DNA replication and repair-deficiency disorders)
these cancers is due to inherited genetic mutations that impair DNA mismatch repair. It is a type of cancer syndrome. Other HNPCC conditions include...
47 KB (4,902 words) - 21:19, 19 February 2024
DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch...
17 KB (2,080 words) - 15:35, 9 January 2024
Base excision repair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle...
29 KB (3,493 words) - 00:14, 22 June 2024
major deleted tumor suppressor loci. Mutations in genes employed in DNA mismatch repair (MMR) cause a high mutation rate. In tumors, such frequent subsequent...
25 KB (2,804 words) - 06:09, 10 June 2024
Howard Hughes Medical Institute. He is known for his research on DNA mismatch repair. Modrich received the Nobel Prize in Chemistry 2015, jointly with...
9 KB (711 words) - 08:24, 16 April 2024
MutS is a mismatch DNA repair protein, originally described in Escherichia coli. Mismatch repair contributes to the overall fidelity of DNA replication...
8 KB (900 words) - 00:35, 16 December 2020
Powdery mildew (section DNA repair)
needed] DNA mismatch repair (MMR) is an enzymatic system for recognizing and repairing erroneous base insertions, deletions, and mis-incorporations in DNA that...
28 KB (2,790 words) - 23:05, 15 June 2024
07.009. PMC 4862604. PMID 26437586. Kunkel TA, Erie DA (2005). "DNA mismatch repair". Annual Review of Biochemistry. 74: 681–710. doi:10.1146/annurev...
79 KB (9,956 words) - 11:19, 14 March 2024
DNA mismatch repair protein Mlh3 is a protein that in humans is encoded by the MLH3 gene. This gene is a member of the MutL-homolog (MLH) family of DNA...
12 KB (1,528 words) - 20:01, 27 October 2023
Base pair (redirect from Base pair mismatch)
sequence of normal DNA base pairs. To repair mismatches formed during DNA replication, several distinctive repair processes have evolved to distinguish between...
32 KB (3,677 words) - 10:59, 1 December 2023
Cell damage (section DNA damage and repair)
employed in repairing different types of DNA damages. These five pathways are nucleotide excision repair, base excision repair, mismatch repair, non-homologous...
23 KB (2,829 words) - 04:04, 16 January 2024
hypermutability (predisposition to mutation) that results from impaired DNA mismatch repair (MMR). The presence of MSI represents phenotypic evidence that MMR...
21 KB (2,633 words) - 08:51, 11 December 2023
on DNA/RNA hybrid). It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in DNA mismatch repair and...
14 KB (1,638 words) - 21:44, 23 December 2023
Crustacean (section DNA repair)
associated with the DNA repair processes of non-homologous end joining, homologous recombination, base excision repair and DNA mismatch repair. The name "crustacean"...
57 KB (4,861 words) - 10:46, 3 June 2024
Cell (biology) (section DNA repair)
organism with diverse well-defined DNA repair processes. These include: nucleotide excision repair, DNA mismatch repair, non-homologous end joining of double-strand...
60 KB (6,271 words) - 20:47, 13 July 2024
Nuclease (section Mismatch repair)
the processing of Okazaki fragments. DNA mismatch repair in any given organism is effected by a suite of mismatch-specific endonucleases. In prokaryotes...
22 KB (2,535 words) - 04:02, 28 October 2023
Neoplasm (section DNA damage)
defective in DNA mismatch repair or in homologous recombinational repair (HRR). During repair of DNA double strand breaks, or repair of other DNA damages,...
51 KB (5,873 words) - 11:57, 11 July 2024
deficiency (HRD): DNA double-strand break requires homologous recombination mechanism for accurate repair of breakpoints. DNA mismatch repair (MMR) deficiency:...
39 KB (4,037 words) - 23:13, 8 March 2024
Muir–Torre syndrome (category DNA replication and repair-deficiency disorders)
affected are MLH1, MSH2, and more recently, MSH6, and are involved in DNA mismatch repair. Muir–Torre syndrome is characterized by both: At least a single...
13 KB (1,492 words) - 18:16, 3 December 2023
in DNA mismatch repair. A role for this protein in mismatch repair has not been proven. However, the protein forms heterodimers with MLH1, a DNA mismatch...
8 KB (958 words) - 18:32, 9 April 2024
relate to mechanisms of human carcinogenesis by papillomaviruses and DNA mismatch repair deficiency, the identification of novel diagnostic markers and potential...
10 KB (1,095 words) - 10:38, 31 December 2023