In molecular biology, G-quadruplex secondary structures (G4) are formed in nucleic acids by sequences that are rich in guanine. They are helical in shape...
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I-motif DNA (section G-quadruplex formation)
intercalated-motif DNA, are cytosine-rich four-stranded quadruplex DNA structures, similar to the G-quadruplex structures that are formed in guanine-rich regions...
54 KB (7,091 words) - 13:50, 28 August 2024
Look up quadruplex in Wiktionary, the free dictionary. Quadruplex may refer to: Quadruplex (New Orleans), a softball complex in New Orleans City Park Quadruplex...
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Antiparallel (biochemistry) (section G-quadruplexes)
normally located at the telomeres (the ends of the chromosomes). The G-quadruplex can either be parallel or antiparallel depending on the loop configuration...
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Hoogsteen base pair (section Quadruplex structures)
pairs are observed in alternative structures such as the four-stranded G-quadruplex structures that form in DNA and RNA. Hoogsteen pairs have quite different...
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classes of cruciform DNA have been described; folded and unfolded. G-quadruplex G-quadruplex secondary structures (G4) are formed in nucleic acids by sequences...
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Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA...
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improved drugs with enhanced specificity. He has led in the study of G-quadruplex nucleic acids as therapeutic targets, especially focussing on their structure...
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needed] There are also triple-stranded DNA forms and quadruplex forms such as the G-quadruplex and the i-motif. Twin helical strands form the DNA backbone...
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four guanine residues form a near planar base quartet, referred to as G-quadruplex, where each guanine participates in base pairing with its neighboring...
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DNA (section Quadruplex structures)
flat four-base units then stack on top of each other to form a stable G-quadruplex structure. These structures are stabilized by hydrogen bonding between...
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Guanine tetrad (redirect from G tetrad)
the structure. Usually, there are at least two guanine tetrads in a G-quadruplex, and they often feature Hoogsteen-style hydrogen bonding. Guanine tetrads...
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Lin & Chun-Ting Zhang (2008). "Greglist: a database listing potential G-quadruplex regulated genes". Nucleic Acids Res. 36 (suppl 1) (Database issue): D372–D376...
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enantioselectivity were related to the DNA sequence. The hemin/G-Quadruplex DNAzyme consists of G-Quadruplex forming DNA that can bind the co-factor hemin (a.k.a...
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apparent affinity for the G-quadruplex structure. They appear to modulate alternative splicing via the interaction with the G-quadruplex RNA-forming structure...
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DHX36 (category G-quadruplex)
DHX36-specific motif, which recognizes the 5'-most G-quadruplex quartet. The OB-fold domain binds to the 3'-most G-tract sugar-phosphate backbone. Like all the...
10 KB (1,267 words) - 03:06, 13 October 2022
18.7049. PMC 297991. PMID 2780561. Lipps HJ, Rhodes D (August 2009). "G-quadruplex structures: in vivo evidence and function". Trends in Cell Biology. 19...
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tetrad (also known as a G-tetrad or G-quartet) and when two or more guanine tetrads stack on top of each other, they form a G-quadruplex. These complex structures...
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mainly of tandem TTAGGG repeats. These repeats fold into highly organized G quadruplex structures which protect the ends of chromosomal DNA from degradation...
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with two helical strands and an internal bulge with a G-quadruplex motif. It is at this G-quadruplex that the fluorophore binds. Based on crystallographic...
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miRNA:miRNA* pairing also affects cleavage. Some of the G-rich pre-miRNAs can potentially adopt the G-quadruplex structure as an alternative to the canonical stem-loop...
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form a quadruplex in RNA by Hoogsteen hydrogen bonds to form a “Hoogsteen ring” (See Figure). G-C and A-U pairs can also form base quadruplex with a combination...
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Promoter (genetics) (section CpG islands in promoters)
indicates that several genes (including the proto-oncogene c-myc) have G-quadruplex motifs as potential regulatory signals. Promoters are important gene...
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8-oxo-dG is formed in a guanine rich, potential G-quadruplex-forming sequence (PQS) in the coding strand of a promoter, active OGG1 excises the 8-oxo-dG and...
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functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents...
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DNA oxidation at a guanine, occurs when an 8-oxo-dG is formed in a guanine rich, potential G-quadruplex-forming sequence (PQS) in the coding strand of a...
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and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs". Nature Structural & Molecular Biology. 19 (8): 837–44...
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in telomere maintenance and replication, especially the replication of the G-rich sequences. WRN is an oligomer that can act as a monomer when unwinding...
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DNA Holliday junctions Triple-stranded DNA, quadruple-stranded DNA (G-quadruplex) Double-stranded hybrids of DNA and RNA (one strand is DNA, the other...
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