estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene. GPER binds to and is...
35 KB (3,987 words) - 16:29, 25 July 2024
Fulvestrant (category GPER agonists)
activity, fulvestrant is an agonist of the G protein-coupled estrogen receptor (GPER), albeit with relatively low affinity (10–100 nM, relative to 3–6 nM for...
27 KB (2,341 words) - 12:12, 14 June 2024
Estriol (category GPER antagonists)
high concentrations (~1,000–10,000 nM) also acts as an antagonist of the GPER, a membrane estrogen receptor where, conversely, estradiol acts as an agonist...
22 KB (2,085 words) - 09:24, 22 July 2024
Estradiol (category GPER agonists)
Estradiol also acts as an agonist of membrane estrogen receptors (mERs), such as GPER (GPR30), a recently discovered non-nuclear receptor for estradiol, via which...
75 KB (7,245 words) - 18:33, 11 August 2024
cytoplasmic GPER is associated with lower grade tumors and nuclear GPER with higher rates of metastasis. The signaling pathways associated with the GPER protein...
27 KB (3,317 words) - 11:14, 7 January 2024
and activate rapid-signaling membrane estrogen receptors (mERs), such as GPER (GPR30). In addition to their role as natural hormones, estrogens are used...
73 KB (7,782 words) - 14:21, 7 August 2024
Niacin (category GPER agonists)
niacin and nicotinamide activate the G protein-coupled estrogen receptor (GPER) in vitro. In 2024, it was reported that metabolites of niacin promote vascular...
92 KB (8,789 words) - 16:52, 1 July 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
92 KB (9,328 words) - 04:45, 11 July 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
181 KB (17,324 words) - 15:24, 6 August 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
82 KB (8,473 words) - 23:42, 9 July 2024
transcription signature induced by estradiol that is independent of the ERα/ERβ and GPER and was identified using the membrane-impermeable estradiol conjugate E2-BSA...
2 KB (158 words) - 06:32, 2 November 2023
recent milestones on the long and winding road from electrocortin to KCNJ5, GPER, and beyond". Hypertension. 63 (1): 19–21. doi:10.1161/HYPERTENSIONAHA.113...
85 KB (9,165 words) - 20:24, 27 May 2024
Nonylphenol (category GPER agonists)
nonyl sidechain. Nonylphenol has been found to act as an agonist of the GPER (GPR30). Nonylphenols fall into the general chemical category of alkylphenols...
40 KB (4,558 words) - 23:32, 16 May 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
67 KB (6,821 words) - 20:22, 2 August 2024
found to bind and activate membrane steroid receptors, such as estradiol and GPER. Gonadotropin-releasing hormone receptor Gonadotropin receptor Steroid hormone...
1 KB (122 words) - 20:18, 13 October 2022
2-Methoxyestradiol (category GPER agonists)
activity as a high-affinity agonist of the G protein-coupled estrogen receptor (GPER) (10 nM, relative to 3–6 nM for estradiol). 2-Methoxyestradiol was being...
10 KB (827 words) - 04:16, 15 January 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
48 KB (4,588 words) - 23:56, 18 July 2024
Filardo EJ (February 2018). "A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis,...
131 KB (14,807 words) - 00:05, 15 August 2024
Chlordecone (category GPER agonists)
cancer in women". Chlordecone has been found to act as an agonist of the GPER (GPR30), which interacts strongly with the estrogen sex hormone estradiol...
17 KB (1,559 words) - 19:55, 7 June 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
12 KB (870 words) - 22:35, 30 December 2023
family of intracellular receptors, and membrane estrogen receptors (mERs) (GPER (GPR30), ER-X, and Gq-mER), which are mostly G protein-coupled receptors...
35 KB (3,818 words) - 03:47, 30 July 2024
Protocatechuic aldehyde regulates G protein-coupled estrogen receptor-1 (GPER-1) and exhibits protective effects in endothelial dysfunction and atherosclerosis...
4 KB (243 words) - 22:49, 9 August 2023
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
27 KB (2,274 words) - 02:54, 22 March 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
149 KB (15,717 words) - 06:34, 13 August 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
7 KB (617 words) - 08:54, 11 June 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
17 KB (1,509 words) - 01:34, 14 June 2024
Zearalenone (category GPER modulators)
estrogen receptors, zearalenone has been found to act as an agonist of the GPER (GPR30). Zearalenone is a white crystalline solid, with molecular formula...
16 KB (1,692 words) - 03:25, 28 June 2024
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
60 KB (6,624 words) - 07:14, 28 July 2024
Retrieved 1 February 2016. Scaling AL, Prossnitz ER, Hathaway HJ (June 2014). "GPER mediates estrogen-induced signaling and proliferation in human breast epithelial...
123 KB (11,581 words) - 15:07, 12 August 2024
DDT (category GPER agonists)
Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Niacin Niacinamide Nonylphenol Oleuropein PCBs...
127 KB (13,008 words) - 03:51, 12 August 2024