roles in which oxytosis/ferroptosis can contribute to the medical field, such as the development of cancer therapies. Ferroptosis activation plays a regulatory...

levels. ALOX5-mediated ferroptosis acts as a cell death pathway upon oxidative stress in Huntington's disease. Inhibitors of ferroptosis are protective in...

Sadovsky, H Bayır, Y Tyurina, R He, V Kagan "iPLA2G6 Protects Cells against Ferroptosis by Hydrolyzing the Lipid Signal of Death, 15-HpETE-PE: Relevance to Parkinson...

disease progression, an iron-dependent form of regulated cell death called ferroptosis could be involved. Products of lipid peroxidation are also elevated in...

balance of these enzymes a central regulator of ferroptosis. Chelation of iron also inhibits ferroptosis, possibly by depleting iron from lipoxygenases...

Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. (May 2012). "Ferroptosis: an iron-dependent form of nonapoptotic cell death". Cell. 149 (5): 1060–1072...

membrane permeabilization and ferroptosis in breast cancer. While mesenchymal breast cancer cells are vulnerable to ferroptosis, ironomycin and salinomycin...

process of ferroptosis, coined the term ferroptosis, described its key mechanisms, and developed the first chemical probes to control ferroptosis. In 2014...

et al. (2020). "MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis". Nature Metabolism. 2 (3): 270–277. bioRxiv 10.1101/325266. doi:10...

were found to have a secondary role protecting against cell death by ferroptosis in cellular models by limiting the formation of toxic lipid peroxides...

cornification, a form of cell death exclusive to the eyes; excitotoxicity; ferroptosis, an iron-dependent form of cell death and Wallerian degeneration. Plant...

cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis". eLife. 3: e02523. doi:10.7554/eLife.02523. PMC 4054777. PMID 24844246...

peroxidation in the aging retina, and their intimate role in ferroptosis, have implicated ferroptosis in AMD pathogenesis. A plethora of in vivo risk factors...

the suppression of tumor growth, inducing apoptosis, and activating ferroptosis. Solasonine enhances anticancer potential by inducing apoptosis, or programmed...

cumulatively lead to cell death. Prolonged store depletion can protect against ferroptosis via remodeling of ER-synthesized phospholipids. Thapsigargin treatment...

; Mourão, André (November 2019). "FSP1 is a glutathione-independent ferroptosis suppressor". Nature. 575 (7784): 693–698. Bibcode:2019Natur.575..693D...

(April 2022). "COVID-19-Related Brain Injury: The Potential Role of Ferroptosis". Journal of Inflammation Research. 15: 2181–2198. doi:10.2147/JIR.S353467...

Apoptosis-inducing factor 2 (AIFM2), also known as ferroptosis suppressor protein 1 (FSP1), apoptosis-inducing factor-homologous mitochondrion-associated...

which indirectly protect tumor cells from ferroptosis ('iron death'), emphasizing the need for ferroptosis inducers (thiostrepton) for cancer treatment...

three main mechanisms: necroptosis via RIPK1, FADD, RIPK3, and MLKL, ferroptosis via GPX4 suppression, system Xc suppression, and NAPDH loss, as well...

location protects the omega−3 fatty acid from lipid peroxidation and ferroptosis. This table lists several different names for the most common omega−3...

cornification, a form of cell death exclusive to the epidermis; excitotoxicity; ferroptosis, an iron-dependent form of cell death and Wallerian degeneration. Necroptosis...

Skidmore J, Devos D, Hammond TR (2023). "Therapeutic inhibition of ferroptosis in neurodegenerative disease". Trends in Pharmacological Sciences. 44...

alkyl chains have been shown to promote or inhibit the cell death from ferroptosis, depending on their degree of saturation. During inflammation, neutrophil-derived...

leukemia U937 cells. Autolysis Autophagy Cisplatin Cytotoxicity Entosis Ferroptosis Homeostasis Immunology Necrobiosis Necrosis Necrotaxis Nemosis Mitotic...

and tetrahydrobiopterin were found to protect against cell death by ferroptosis. Tetrahydrobiopterin (BH4) acts as a potent, diffusable antioxidant that...

(2024). Liao, P., et al. CD8(+) T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell, doi:10.1016/j.ccell.2022.02.003(2022)...

mitochondrial DNA copy number. XJB-5-131 also strongly protects against ferroptosis, a form of iron-dependent regulated cell death. Xun Z, Rivera-Sánchez...

Kagan VE, Schick JA, Conrad M (17 November 2014). "Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice". Nature Cell Biology...

ischemic-reperfusion related injuries. Utreloxastat is a redox‐active inhibitor of ferroptosis. Utreloxastat has reached Phase 2 clinical trials for the treatment of...