GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression...
31 KB (3,723 words) - 06:25, 25 July 2024
dependent on the microbiome. Gata3+ T regs are major immunosuppressors during intestinal inflammation and T regs use Gata3 to limit tissue inflammation...
79 KB (9,493 words) - 15:51, 21 June 2024
Haploinsufficiency (deletions) of zinc-finger transcription factor GATA3 or mutations in the GATA3 gene appear to be the underlying cause of this syndrome. It...
10 KB (884 words) - 20:08, 17 January 2024
IL-4/IL-5 CD4 T cells. The key Th2 transcription factors are STAT6 and GATA3. IL-4 is the positive feedback cytokine for Th2 cells differentiation. Besides...
54 KB (6,597 words) - 14:51, 21 July 2024
necessary. Intracellular GATA3 expression is a crucial component of T cell receptor beta (TCRš½) allelic exclusion in mammalian cells. GATA3 transgenic overexpression...
17 KB (1,896 words) - 23:25, 5 September 2023
change. In humans: GATA1 (see also GATA1) GATA2 (see also GATA2) GATA3 (see also GATA3) GATA4 (see also GATA4) GATA5 (see also GATA5) GATA6 (see also GATA6)...
8 KB (995 words) - 06:20, 25 July 2024
role in the development of the parathyroid gland. The genes, TBX1, CRKL, GATA3, GCM2, and SOX3 have also been shown to play a crucial role in the formation...
39 KB (4,602 words) - 10:52, 11 August 2024
cells (Tregs) to modulate gut immunity, thus increasing the expression of Gata3 and FoxP3 genes. The colonization of Clostridium spp. can enhance the aggregation...
100 KB (11,098 words) - 14:21, 18 August 2024
repair system in cells Hot dry rock, a form of geothermal energy production GATA3, a protein also named HDR HDR, Inc., an American architectural and engineering...
1 KB (214 words) - 12:10, 10 December 2023
inherited risk factors include mutations in ARID5B, CDKN2A/2B, CEBPE, IKZF1, GATA3, PIP4K2A and, more rarely, TP53. These genes play important roles in cellular...
77 KB (7,766 words) - 03:16, 21 July 2024
PMCĀ 1215508. PMIDĀ 16150156. Mantilla JG, Antic T, Tretiakova M (2017). "GATA3 as a valuable marker to distinguish clear cell papillary renal cell carcinomas...
55 KB (5,119 words) - 09:51, 31 July 2024
ima04as80. PMCĀ 7162157. PMIDĀ 18432634. Ho IC, Tai TS, Pai SY (February 2009). "GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell...
14 KB (1,368 words) - 18:49, 18 August 2024
specific genes, many of which have been identified in previous research (SOX2, GATA3, EYA1, FOXG1, BMP4, RAC1, and more), to undergo such differentiation. Specifically...
17 KB (2,095 words) - 05:40, 26 October 2023
expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Molecular and Cellular Biology. 18 (12): 6939ā6950. doi:10.1128/MCB.18...
31 KB (2,906 words) - 07:45, 19 August 2024
contact the DNA. FOXA1 in breast cancer is highly correlated with ERĪ±+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts...
7 KB (802 words) - 18:08, 19 April 2024
ENSG00000179348 GATA Known motif ā High-throughput in vitro [290] VHGATAHSV GATA3 ENSG00000107485 GATA Known motif ā High-throughput in vitro [291] HGATAAVV...
374 KB (81 words) - 02:10, 23 September 2023
fundamental transcription factors RORĪ± and GATA3. GATA3 is also required for maintenance of ILC2 function, with GATA3 deprivation inhibiting the development...
95 KB (10,510 words) - 14:56, 28 March 2024
HGNC:4164 P01350 6087 GATA1 HGNC:4170 P15976 6088 GATA2 HGNC:4171 P23769 6089 GATA3 HGNC:4172 P23771 6090 GATA4 HGNC:4173 P43694 6091 GATA5 HGNC:15802 Q9BWX5...
277 KB (17 words) - 15:46, 9 May 2024
expression analysis of two T helper master transcription factors, T-bet and GATA3, in rainbow trout Oncorhynchus mykiss and analysis of their expression during...
11 KB (1,305 words) - 12:28, 16 May 2024
encoding protein FERM and PDZ domain containing 2 GATA3: encoding the GATA3 transcription factor. GATA3 is critical for the embryonic development of the...
28 KB (1,967 words) - 02:02, 11 April 2024
Autosomal recessive spastic paraplegia Barakat syndrome (HDR syndrome) 146255 GATA3 Basal cell nevus syndrome 109400 PTCH1, PTCH2, SUFU Branchioāoculoāfacial...
35 KB (2,499 words) - 18:40, 12 July 2024
estrogen and progesterone receptor negative Gene mutations PI3KCA MAPK3K1 GATA3 CCDN1 amplification Similar to luminal A but: TP53 inactivation Rb inactivation...
92 KB (9,503 words) - 14:29, 12 August 2024
overexpression have emerged from these studies: the malignant cells may overexpress GATA3, MYC, mTOR, and Ī²-catenin genes or, alternatively, the TBX21, interferon-Ī³...
139 KB (16,933 words) - 15:26, 5 July 2024
carcinoma distinct from ductal carcinoma; FOXA1 elevated in lobular carcinoma, GATA3 elevated in ductal carcinoma; lobular carcinoma enriched for PTEN loss and...
82 KB (7,468 words) - 19:06, 19 April 2024
treatment of estrogen receptor negative androgen receptor positive luminal (GATA3 expressing) breast cancer. The regimen was designed in order to mimic the...
3 KB (308 words) - 11:19, 15 March 2024
IL-5 expression is regulated by several transcription factors including GATA3. IL-5 has long been associated with the cause of several allergic diseases...
13 KB (1,523 words) - 19:27, 26 June 2024
pathways in the lymphocyte. This up-regulation is directly controlled by GATA3 transcription factor. IL-33 combined with IL-2, IL-7 or TSLP also stimulates...
49 KB (6,005 words) - 16:30, 10 June 2024
Aprelikova O, El Touny LH, Kouros-Mehr H, Green JE (2013). "Expression of GATA3 in MDA-MB-231 triple-negative breast cancer cells induces a growth inhibitory...
59 KB (6,833 words) - 23:23, 18 May 2024
by a type 2 helper T cell (Th2). By targeting the transcription factor, GATA3, of the Th2 pathway, with DNAzyme it may be possible to negate the inflammation...
40 KB (4,795 words) - 07:48, 22 February 2024