GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression...

dependent on the microbiome. Gata3+ T regs are major immunosuppressors during intestinal inflammation and T regs use Gata3 to limit tissue inflammation...

Haploinsufficiency (deletions) of zinc-finger transcription factor GATA3 or mutations in the GATA3 gene appear to be the underlying cause of this syndrome. It...

IL-4/IL-5 CD4 T cells. The key Th2 transcription factors are STAT6 and GATA3. IL-4 is the positive feedback cytokine for Th2 cells differentiation. Besides...

necessary. Intracellular GATA3 expression is a crucial component of T cell receptor beta (TCR𝛽) allelic exclusion in mammalian cells. GATA3 transgenic overexpression...

change. In humans: GATA1 (see also GATA1) GATA2 (see also GATA2) GATA3 (see also GATA3) GATA4 (see also GATA4) GATA5 (see also GATA5) GATA6 (see also GATA6)...

role in the development of the parathyroid gland. The genes, TBX1, CRKL, GATA3, GCM2, and SOX3 have also been shown to play a crucial role in the formation...

cells (Tregs) to modulate gut immunity, thus increasing the expression of Gata3 and FoxP3 genes. The colonization of Clostridium spp. can enhance the aggregation...

repair system in cells Hot dry rock, a form of geothermal energy production GATA3, a protein also named HDR HDR, Inc., an American architectural and engineering...

inherited risk factors include mutations in ARID5B, CDKN2A/2B, CEBPE, IKZF1, GATA3, PIP4K2A and, more rarely, TP53. These genes play important roles in cellular...

PMC 1215508. PMID 16150156. Mantilla JG, Antic T, Tretiakova M (2017). "GATA3 as a valuable marker to distinguish clear cell papillary renal cell carcinomas...

the nucleus in differentiated keratinocytes. It has also been shown that GATA3 induces differentiation of primary keratinocytes, and suggested that it...

ima04as80. PMC 7162157. PMID 18432634. Ho IC, Tai TS, Pai SY (February 2009). "GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell...

specific genes, many of which have been identified in previous research (SOX2, GATA3, EYA1, FOXG1, BMP4, RAC1, and more), to undergo such differentiation. Specifically...

expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Molecular and Cellular Biology. 18 (12): 6939–6950. doi:10.1128/MCB.18...

contact the DNA. FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts...

ENSG00000179348 GATA Known motif – High-throughput in vitro [290] VHGATAHSV GATA3 ENSG00000107485 GATA Known motif – High-throughput in vitro [291] HGATAAVV...

fundamental transcription factors RORα and GATA3. GATA3 is also required for maintenance of ILC2 function, with GATA3 deprivation inhibiting the development...

HGNC:4164 P01350 6087 GATA1 HGNC:4170 P15976 6088 GATA2 HGNC:4171 P23769 6089 GATA3 HGNC:4172 P23771 6090 GATA4 HGNC:4173 P43694 6091 GATA5 HGNC:15802 Q9BWX5...

expression analysis of two T helper master transcription factors, T-bet and GATA3, in rainbow trout Oncorhynchus mykiss and analysis of their expression during...

encoding protein FERM and PDZ domain containing 2 GATA3: encoding the GATA3 transcription factor. GATA3 is critical for the embryonic development of the...

Autosomal recessive spastic paraplegia Barakat syndrome (HDR syndrome) 146255 GATA3 Basal cell nevus syndrome 109400 PTCH1, PTCH2, SUFU Branchio‐oculo‐facial...

estrogen and progesterone receptor negative Gene mutations PI3KCA MAPK3K1 GATA3 CCDN1 amplification Similar to luminal A but: TP53 inactivation Rb inactivation...

overexpression have emerged from these studies: the malignant cells may overexpress GATA3, MYC, mTOR, and β-catenin genes or, alternatively, the TBX21, interferon-γ...

carcinoma distinct from ductal carcinoma; FOXA1 elevated in lobular carcinoma, GATA3 elevated in ductal carcinoma; lobular carcinoma enriched for PTEN loss and...

treatment of estrogen receptor negative androgen receptor positive luminal (GATA3 expressing) breast cancer. The regimen was designed in order to mimic the...

IL-5 expression is regulated by several transcription factors including GATA3. IL-5 has long been associated with the cause of several allergic diseases...

pathways in the lymphocyte. This up-regulation is directly controlled by GATA3 transcription factor. IL-33 combined with IL-2, IL-7 or TSLP also stimulates...

Aprelikova O, El Touny LH, Kouros-Mehr H, Green JE (2013). "Expression of GATA3 in MDA-MB-231 triple-negative breast cancer cells induces a growth inhibitory...

by a type 2 helper T cell (Th2). By targeting the transcription factor, GATA3, of the Th2 pathway, with DNAzyme it may be possible to negate the inflammation...