Thalassemias are inherited blood disorders that result in abnormal hemoglobin. Symptoms depend on the type of thalassemia and can vary from none to severe...
67 KB (7,132 words) - 02:15, 19 October 2024
Beta thalassemias (β thalassemias) are a group of inherited blood disorders. They are forms of thalassemia caused by reduced or absent synthesis of the...
57 KB (5,458 words) - 22:49, 19 September 2024
Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 and HBA2. Thalassemias are a group of inherited blood...
21 KB (1,588 words) - 22:52, 19 August 2024
Delta-beta thalassemia is a rare form of thalassemia in which there is a reduced production of hemoglobin subunit delta and hemoglobin subunit beta and...
8 KB (663 words) - 20:48, 14 August 2024
Hemoglobin A (section Alpha-thalassemia)
to have a “silent” α-thalassemia whereas, if the mutation is on both then it is considered an α-thalassemia trait. α-thalassemia is mostly found in sub-tropical...
17 KB (2,060 words) - 02:04, 22 June 2024
Hemoglobin A2 (section Thalassemia)
Hemoglobin A2 may be increased in beta thalassemia or in people who are heterozygous for the beta thalassemia gene. HbA2 exists in small amounts in all...
9 KB (1,220 words) - 16:12, 24 September 2024
Treatment of the inherited blood disorder thalassemia depends upon the level of severity. For mild forms of the condition, advice and counseling are often...
44 KB (4,881 words) - 19:24, 3 October 2024
variants are HbS, HbE and HbC. The main types of thalassemia are alpha-thalassemia and beta thalassemia. The two conditions may overlap because some conditions...
19 KB (2,206 words) - 18:01, 24 April 2024
Microcytic anemia (section Thalassemia)
general and of microcytic anemia in particular Thalassemia Adulthood Iron deficiency anemia Thalassemia Anemia of chronic disease Rare hereditary causes...
16 KB (1,705 words) - 22:21, 26 September 2023
ATR-X syndrome (redirect from X-linked alpha thalassemia mental retardation syndrome)
Alpha-thalassemia mental retardation syndrome (ATRX), also called alpha-thalassemia X-linked intellectual disability syndrome, nondeletion type or ATR-X...
10 KB (1,149 words) - 11:06, 22 April 2024
the treatment of sickle cell disease and transfusion-dependent beta thalassemia. It was developed by Vertex Pharmaceuticals and CRISPR Therapeutics....
20 KB (1,447 words) - 04:01, 7 September 2024
Hemoglobin subunit beta (section Beta thalassemia)
implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria....
18 KB (2,398 words) - 03:47, 2 May 2024
amounts of anomalous β mRNA. The reduced synthesis of β chain may cause β-thalassemia. Also, this hemoglobin variant has a weak union between α- and β-globin...
13 KB (1,249 words) - 02:10, 7 July 2024
Transfusion-dependent anemia (section Thalassemia)
and transfusion-dependent thalassemia is diagnosed based on gene mutations. Screening for heterozygosity in the thalassemia gene is an option for early...
25 KB (2,866 words) - 08:04, 7 October 2024
said to be helpful in differentiating iron deficiency anemia from beta thalassemia trait. The index is calculated from the results of a complete blood count...
3 KB (293 words) - 15:06, 28 June 2023
alpha-thalassemia intermedia, is a disease affecting hemoglobin, the oxygen carrying molecule within red blood cells. It is a form of Alpha-thalassemia which...
9 KB (936 words) - 14:34, 26 April 2024
Sickle cell-beta thalassemia is an inherited blood disorder. The disease may range in severity from being relatively benign and like sickle cell trait...
4 KB (341 words) - 13:46, 21 March 2024
heterozygous (inherited in only one of the chromosome 11) HbD trait, HbD-thalassemia, HbS-D (sickle cell) disease, and, very rarely, homozygous (inherited...
32 KB (3,700 words) - 16:00, 26 September 2024
hemoglobin, such as hemoglobin C. It can also be used to investigate thalassemias, which are disorders caused by defective hemoglobin production. The test...
5 KB (540 words) - 13:30, 12 July 2024
name Reblozyl, is a medication used for the treatment of anemia in beta thalassemia and myelodysplastic syndromes. The US Food and Drug Administration (FDA)...
11 KB (799 words) - 20:36, 19 August 2024
attributed to various anemias, most often; beta thalassemia major, a form of microcytic anemia. In β thalassemia major the beta hemoglobin chain is completely...
2 KB (132 words) - 19:19, 1 December 2023
chain that is abnormally long. It is the most common nondeletional alpha-thalassemia mutation associated with hemoglobin H disease. The quantity of hemoglobin...
2 KB (146 words) - 02:51, 29 September 2019
hemochromatosis is common in patients with certain types of chronic anemia (e.g. thalassemia and myelodysplastic syndrome) who require many blood transfusions, which...
18 KB (1,475 words) - 13:01, 20 August 2024
iron deficiency anemia and decreased or normal in thalassemia major (Cooley's anemia), thalassemia intermedia Anisocytosis with normal RBC size – Early...
3 KB (267 words) - 06:08, 11 September 2024
include iron deficiency, folate deficiency, vitamin B12 deficiency, thalassemia and a number of bone marrow tumors. Causes of increased breakdown include...
85 KB (8,824 words) - 09:44, 9 October 2024
betibeglogene autotemcel (Zynteglo), which treats transfusion-dependent beta thalassemia (TDT), a rare genetic blood disorder, and has been approved for use by...
15 KB (1,409 words) - 21:01, 17 October 2024
globins bind to form hemoglobin Barts. It is produced in the disease alpha-thalassemia and in the most severe of cases, it is the only form of hemoglobin in...
9 KB (1,049 words) - 04:38, 28 April 2024
Fetal hemoglobin (section Delta beta-thalassemia)
adult forms of hemoglobin begin to be produced. Diseases such as beta thalassemias, which affect components of the adult hemoglobin, can delay this process...
38 KB (4,538 words) - 23:06, 16 September 2024
organisation. It is a youth organisation working for blood donation, thalassemia, bone marrow transplantation and disaster relief.[citation needed] Since...
10 KB (869 words) - 14:26, 10 October 2024
commercialize medicines for various diseases including sickle cell disease, beta thalassemia, various cancers, type 1 diabetes, and cardiovascular diseases. The CEO...
11 KB (918 words) - 14:13, 19 April 2024