The tumor microenvironment is a complex ecosystem surrounding a tumor, composed of cancer cells, stromal tissue (including blood vessels, immune cells...

essential to maintain self-tolerance. In a tumor, however, Tregs form an immunosuppressive microenvironment. Tumor cells produce special cytokines (such as...

tumor cells. See the Natural killer cell page for further information on NK cells in tumor surveillance. ILC1s influence the tumor microenvironment by...

Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors. They are heavily involved...

site of many tumors. Studies in both humans and animal models have implicated that high numbers of Treg cells in the tumor microenvironment is indicative...

company. It develops oncology therapies designed to target the tumor microenvironment. The company was founded in 1998 and went public in 2004. Halozyme...

downregulated. Tumor-associated macrophages (TAMs) have been shown to be abundantly present in the microenvironments of metastasizing tumors. Studies have...

suppressed by the cancer cells. It asserts that the tumor would have been eliminated if the tumor microenvironment had not been suppressive. Rather than employing...

cancer cells by influencing the tumor microenvironment. Oncogenes build up an inflammatory pro-tumorigenic microenvironment. Hormones also play a role in...

Esparvarinha M, et al. (January 2021). "The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing...

and their interactions all contribute to the changing tumor microenvironment, which the tumor largely manipulates to be immunotolerant so as to avoid...

mimicking the tumor microenvironment. Alternatively, a single-cell suspension enables scientists to collect an unbiased sampling of the whole tumor, eliminating...

Controllability in Phenotypically Characterized Osteosarcoma: Role of Tumor Microenvironment". Frontiers in Immunology. 8: 918. doi:10.3389/fimmu.2017.00918...

hyaluronic acid). This creates a tumor microenvironment that is short of blood vessels (hypovascular) and so of oxygen (tumor hypoxia). It is thought that...

associated fibroblast; activated fibroblast) is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling...

contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts...

include E7386, tegavivint and ipafricept. Additionally, the tumor microenvironment in desmoid tumors is being investigated to find new targets for treatment...

1074/jbc.M503707200. PMID 16169856. Le LQ, Parada LF (July 2007). "Tumor microenvironment and neurofibromatosis type I: connecting the GAPs". Oncogene. 26...

secrete mitogens or survival factors that alter the developing tumor microenvironment and result in neurofibroma formation.[citation needed] Dermal and...

environmental factors and molecular changes in the local microenvironment on neoplastic evolution from tumor initiation to patient death. In the colon, a field...

Endothelial Cells in Malignant Tumors. In: Akslen, L.A., Watnick, R.S. (eds) Biomarkers of the Tumor Microenvironment. Springer, Cham. https://doi.org/10...

2015). "The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment". Cancer Microenvironment. 8 (3): 125–58. doi:10.1007/s12307-014-0147-5. PMC 4714999...

Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor Microenvironment". Frontiers in Immunology...

enumeration and characterization of the tumor microenvironment in diverse cancer types and across thousands of tumors, an approach largely led by Ash Alizadeh...

tumors, which adds difficulty to the identification of a target for all tumor cells. 2) Achieving full function of T cells and tumor microenvironment...

of MDSC infiltrate in the tumor microenvironment (TME) correlates with shorter survival times of patients with solid tumors and could mediate resistance...

fewer side effects. Metronomic therapy is shown to affect both tumor microenvironment and tumor cells to achieve its therapeutic effects. Metronomic therapy...

cancer development for example through production of IL-17 in the tumor microenvironment, which promotes angiogenesis and cell growth or because their ability...

regarded as a pioneer in the area of tumor microenvironment and widely recognized for his seminal discoveries in tumor biology, drug delivery, in vivo imaging...

the role of the tumor microenvironment in cancer progression. She is a principal investigator and head of the tumor microenvironment and metastasis branch...