Unlike the action potential in skeletal muscle cells, the cardiac action potential is not initiated by nervous activity. Instead, it arises from a group...

An action potential occurs when the membrane potential of a specific cell rapidly rises and falls. This depolarization then causes adjacent locations...

Lakatta, Edward G. (2015). "Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing". Frontiers in Physiology...

membrane potentials. As the membrane voltage begins to drop the channels recover from inactivation and carry current. Cardiac action potential Grant, Augustus...

important differences. Electrical stimulation in the form of a cardiac action potential triggers the release of calcium from the cell's internal calcium...

cardiomyocytes known as pacemaker cells that can spontaneously generate cardiac action potentials. These signals are propagated through the heart's electrical conduction...

upstroke of the cardiac action potential there is a large influx of Na+ ions. This depolarizes the cell and shifts the membrane potential in the positive...

repolarization peak. Cardiac action potential Vigmond E.J, Tsoi V, Yin Y, Page P, & Vinet A. (2009). Estimating Atrial Action Potential Duration from Electrograms...

vena cava. These cells produce an electrical impulse known as a cardiac action potential that travels through the electrical conduction system of the heart...

the hERG channel mediates the repolarizing IKr current in the cardiac action potential, which helps coordinate the heart's beating. When this channel's...

multiple modes of action, which makes any classification imprecise. The cardiac myocyte has two general types of action potentials: conduction system...

main contributing current during the repolarizing phase 1 of the cardiac action potential. It is a result of the movement of positively charged potassium...

systole). Apex beat Cardiac action potential Cardiac output Pulse Pollock JD, Makaryus AN (3 October 2022). "Physiology: Cardiac cycle". StatPearls Publishing...

each ventricular systole. Cardiac muscle tissue has autorhythmicity, the unique ability to initiate a cardiac action potential at a fixed rate – spreading...

cardiomyocytes with fewer myofibrils and many mitochondria. They conduct cardiac action potentials more quickly and efficiently than any of the other cells in the...

change in voltage is referred to as an action potential. Unlike that in nerve cells, the cardiac action potential duration is closer to 100 ms (with variations...

the entry of sodium in heart cells, causing prolongation of the cardiac action potential. Flecainide was approved for medical use in the United States in...

Cardiac excitation-contraction coupling (Cardiac EC coupling) describes the series of events, from the production of an electrical impulse (action potential)...

contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction. It is a member of the KCNQ...

phase of the cardiac action potential. As such, it plays a major role in impulse propagation through the heart. A vast number of cardiac diseases is associated...

abnormal depolarizations of cardiac myocytes that interrupt phase 2, phase 3, or phase 4 of the cardiac action potential in the electrical conduction...

caused by mutations in genes encoding ion channels that shorten the cardiac action potential, and appears to be inherited in an autosomal dominant pattern....

sustained contractions because it forces the refractory period and cardiac action potential firing to be of the same length of time. Repolarization depends...

cardiotoxicity is defined as cardiac damage that occurs under the action of a drug. This can occur both through damage of cardiac muscle as well as through...

an action potential. The cardiac action potential is created by the movement of specific electrolytes into and out of the pacemaker cells. The action potential...

proteins to be exposed, which causes muscle contraction to occur. The cardiac action potential spreads distally (or outwardly) to the small branches of the Purkinje...

steady heartbeat. At the beginning of the cardiac cycle, the SA node generates an electrical action potential that spreads across the right and left atria...

the increase in sodium permeability of the cardiac myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current...

cardiac sodium channel, NaV1.5, responsible for the sodium current INa which depolarises cardiac cells at the start of the action potential. Cardiac sodium...

involved in cardiac repolarization during phase 3 of the action potential, so that this blockade prolongs the duration of cardiac action potentials, resulting...