along its 5' → 3' direction. CpG sites occur with high frequency in genomic regions called CpG islands. Cytosines in CpG dinucleotides can be methylated...
51 KB (5,481 words) - 20:28, 15 August 2024
CpG may refer to: CpG site - methylated sequences of DNA significant in gene regulation CpG island - regions of DNA that contain several CpG sites CpG...
280 bytes (65 words) - 09:35, 25 January 2024
methylated CpG site (a cytosine followed by guanine along its 5' → 3' direction and where the cytosine is methylated (5-mCpG)). A 5-mCpG site has the lowest...
161 KB (18,346 words) - 02:11, 20 August 2024
CpG site). In mammals, DNA methyltransferases (which add methyl groups to DNA bases) exhibit a strong sequence preference for cytosines at CpG sites....
42 KB (5,154 words) - 13:37, 14 February 2024
DNA methylation (section CpG islands)
occurs on the cytosine nucleotide in a CpG site, in plants the cytosine can be methylated at CpG, CpHpG, and CpHpH sites, where H represents any nucleotide...
114 KB (13,179 words) - 02:59, 22 July 2024
8-Oxo-2'-deoxyguanosine (redirect from 8-OHdG)
(CpG sites). In the mouse brain, 4.2% of all cytosines are methylated, primarily in the context of CpG sites, forming 5mCpG. Most hypermethylated 5mCpG...
25 KB (2,763 words) - 21:16, 13 April 2024
methylated CpG site (a cytosine followed by guanine along its 5' → 3' direction and where the cytosine is methylated (5-mCpG)). A 5-mCpG site has the lowest...
129 KB (15,900 words) - 06:12, 13 August 2024
differentially methylated CpG sites returned to the level of never-smokers within five years of smoking cessation. However, 2,568 CpGs among 942 genes remained...
45 KB (5,235 words) - 16:05, 28 June 2024
mammalian brain, ~62% of CpGs are methylated. Methylation of CpG sites tends to stably silence genes. More than 500 of these CpG sites are de-methylated in...
79 KB (9,956 words) - 00:33, 25 August 2024
Promoter (genetics) (redirect from Promoter site)
transcription start site of a gene (proximal promoters) contain a CpG island. CpG islands are generally 200 to 2000 base pairs long, have a C:G base pair content...
54 KB (6,286 words) - 11:33, 8 August 2024
diabetes. In a normal cell, the bulk genome is highly methylated at CpGs, whereas CpG islands (CPI) at gene promoter regions remain highly unmethylated...
32 KB (3,597 words) - 15:04, 21 April 2024
a demethylation pathway shown in the second figure. The thousands of CpG sites being demethylated during memory formation depend on ROS in an initial...
73 KB (8,482 words) - 12:21, 12 July 2024
occurs in the DNA sequence CpG, changing the DNA at the CpG site from CpG to 5-mCpG. Methylation of cytosines in CpG sites in promoter regions of genes...
17 KB (2,080 words) - 17:17, 26 April 2024
transcription start site of a gene (proximal promoters) contain a CpG island. CpG islands are generally 200 to 2000 base pairs long, have a C:G base pair content...
19 KB (2,390 words) - 22:58, 3 December 2023
along its 5' → 3' direction (at CpG sites). This forms a 5mCpG site. More than 98% of DNA methylation occurs at CpG sites in mammalian somatic cells. Thus...
32 KB (3,984 words) - 05:42, 27 April 2024
guanine, a CpG site. The number of CpG sites in the human genome is about 28 million. Depending on the type of cell, about 70% of the CpG sites have a methylated...
102 KB (11,438 words) - 16:50, 17 July 2024
of CpG dinucleotides (CpG sites), forming 5-methylcytosine (5mC). Thus, a CpG site may be methylated to form 5mCpG. The presence of 5mC at CpG sites in...
52 KB (6,235 words) - 15:49, 26 April 2024
Look up CPG in Wiktionary, the free dictionary. CPG may stand for: Cameron Pace Group, a 4D technology and production company based in Berlin, Germany...
2 KB (306 words) - 18:46, 11 August 2023
Transcription (biology) (redirect from Transcription start site)
controlled by methylation of cytosines within CpG dinucleotides (where 5' cytosine is followed by 3' guanine or CpG sites). 5-methylcytosine (5-mC) is a methylated...
58 KB (6,787 words) - 20:17, 9 August 2024
at a CpG site, which is a cytosine followed by a guanine. The “p” refers to the phosphate linker between them. DMR usually involves adjacent sites or a...
2 KB (223 words) - 19:23, 21 September 2023
mouse sperm genome is 80–90% methylated at its CpG sites in DNA, amounting to about 20 million methylated sites.[citation needed] After fertilization, the...
49 KB (5,387 words) - 17:07, 6 April 2024
DNA methylation dysregulation is the promoter hypermethylation where the CPGs islands in the promoter regions are methylated contributing or causing genes...
30 KB (3,792 words) - 07:03, 18 October 2023
mammalian brain, ~62% of CpGs are methylated. Methylation of CpG sites tends to stably silence genes. More than 500 of these CpG sites are de-methylated in...
40 KB (4,790 words) - 11:12, 24 March 2024
MECP2 (redirect from Methyl CpG binding protein 2)
MECP2 (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. MECP2 appears to be essential for the normal function of nerve cells. The...
28 KB (3,589 words) - 22:53, 2 January 2024
sequence, a CpG site.) Methylation of CpG sites in a promoter region of a gene usually represses gene transcription, while methylation of CpGs in the body...
75 KB (8,057 words) - 04:44, 25 July 2024
CpG island shores. In cancer cells, hypermethylation in the CpG island shores move into CpG islands, or hypomethylation of CpG islands move into CpG island...
111 KB (12,533 words) - 04:42, 11 August 2024
or 5-mCpG). Methylated cytosines within CpG sequences often occur in groups, called CpG islands. About 59% of promoter sequences have a CpG island while...
26 KB (2,836 words) - 19:47, 1 August 2024
the nervous system. This disruption leads to an elevation in methylated CpG sites, causing DNA hypermethylation. The mutations can either occur due to new...
20 KB (1,481 words) - 20:32, 10 April 2024
the bisulfite-converted sequence of specific CpG sites in the region. The ratio of C-to-T at individual sites can be determined quantitatively based on the...
34 KB (4,084 words) - 21:59, 8 January 2024
modification primarily occurs at CpG sites, which in turn tend to cluster in regions called CpG islands. There is a small fraction of CpG islands that can overlap...
23 KB (2,851 words) - 03:32, 18 December 2023