Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes...

to the tolerization of B cells and T cells. Dendritic cells in the germinal center may endocytose such antigenic material and present it to T cells, activating...

forms part of the adaptive immune system. These cells develop within germinal centers of the secondary lymphoid organs. Memory B cells circulate in the blood...

affinity maturation in the germinal center (GC) and produce more antibodies. Plasma cells typically result from the germinal center reaction from T cell-dependent...

to therapies in different ways. Germinal Center B-Cell like (GCB) DLBCLs appear to arise from normal germinal center B cells, while Activated B-cell like...

cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first...

into these seeded germinal centers, predominantly composed of rapidly dividing B cells mutating their Ig genes. Within germinal centers, TFH cells play...

follicles (nodular swirls of various types of lymphocytes) in the germinal centers of lymphoid tissues such as lymph nodes. The cancerous cells in FL...

thyrocyte-associated tissues often leads to the histologically significant finding of germinal center development within the thyroid gland.[citation needed] Hashimoto's...

Look up Germinal in Wiktionary, the free dictionary. Germinal may refer to: Germinal (French Republican Calendar), the seventh month of the calendar, approximately...

body macrophage (TBM) is a type of macrophage predominantly found in germinal centers of lymph nodes. They contain many phagocytized, apoptotic cells in...

proliferating in the germinal center of a lymphoid follicle. They are specifically located in the dark zone of the germinal center. Centroblasts form from...

usually derived from B lymphocytes, classically considered crippled germinal center B cells. In the vast majority of cases, the immunoglobulin genes of...

cystic tumor of the salivary glands containing abundant lymphocytes and germinal centers (lymph node-like stroma). It is named for pathologist Aldred Scott...

follicles with large hyperplastic germinal centers and sheetlike plasmacytosis (increased number plasma cells). Germinal centers may also show regressed features...

(classically described as arising extrafollicularly rather than from the germinal center) which have the potential to differentiate further into plasma cells...

that accompany it, including: Th2 activation and cytokine production, germinal center formation and isotype switching, and affinity maturation and memory...

CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. MCL cells generally over-express...

R, Bradlow B, Platanias LC (2002). "Progressive transformation of germinal centers. Report of 2 cases and review of the literature". Acta Haematol. 108...

activated B cell begins to differentiate into more specialized cells. Germinal center B cells may differentiate into memory B cells or plasma cells. Most...

Affinity maturation primarily occurs on membrane immunoglobulin of germinal center B cells and as a direct result of somatic hypermutation (SHM) and selection...

TLOs that contain an active germinal center tend to have a better prognosis than those with TLOs without a germinal center. The reason that these patients...

capturing antigen to support B cell, promoting debris removal from germinal centers, and protecting against autoimmunity. Disease processes that FDC may...

Toxoplasmosis Syphilis Castleman disease Progressive transformation of germinal centers (PTGC) Microorganisms can infect lymph nodes by causing pain and inflammation...

histiocytic-dendritic disorders. In the "germinal center model" for the normal maturation of B cells, naive B cells enter the germinal centers of lymph nodes and other...

lymphoma. Centrocytes are B cells that are found in the light zones of germinal centers. Centrocytes are the non-dividing progeny of centroblasts, and although...

allows for germinal center development and leads to B cell proliferation. The deletion of BCL6 is known to lead to failure of germinal center formation...

cells are activated and proliferate in areas called germinal centers in the tonsil. These germinal centers are places where B memory cells are created and...

found on non-T ALL cells, which derive from pre-B lymphocytes, and in germinal center-related non-Hodgkin lymphoma such as Burkitt lymphoma and follicular...

(March 2018). "N-methyl-D-aspartate receptor antibody production from germinal center reactions: Therapeutic implications". Annals of Neurology. 83 (3):...