• Thumbnail for Myostatin
    Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. Myostatin is a myokine...
    48 KB (5,322 words) - 17:57, 21 May 2024
  • Myostatin inhibitors are a class of drugs that work by blocking the effects of myostatin, which inhibits muscle growth. In animal models and limited human...
    11 KB (1,195 words) - 05:17, 27 May 2024
  • Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. Affected individuals...
    7 KB (708 words) - 06:35, 16 November 2023
  • Thumbnail for Belgian Blue
    natural mutation in the myostatin gene which codes for the protein, myostatin ("myo" meaning muscle and "statin" meaning stop). Myostatin is a protein that...
    11 KB (1,224 words) - 03:03, 26 October 2023
  • known mutations that limits and reduces the activity of the myostatin protein. Normally, myostatin limits the number of muscle fibers present at birth, and...
    6 KB (823 words) - 13:50, 28 March 2024
  • Thumbnail for Limousin cattle
    identified a natural variant of the myostatin gene found in Limousins which has a significant influence on them. The myostatin gene is found in all mammals and...
    86 KB (10,454 words) - 13:47, 10 January 2024
  • Myokine (section Myostatin)
    the term myokine first occurred in 2003. In 2008, the first myokine, myostatin, was identified. The gp130 receptor cytokine IL-6 (Interleukin 6) was...
    36 KB (4,564 words) - 08:42, 19 February 2024
  • Thumbnail for Piedmontese cattle
    Piedmontese cattle carry a unique gene mutation identified as an inactive myostatin allele that causes hypertrophic muscle growth, or double muscling. Purebred...
    8 KB (734 words) - 17:37, 30 December 2023
  • Thumbnail for YK-11
    PMID 23995658. Lee SJ, Gharbi A, Shin JE, Jung ID, Park YM (March 2021). "Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis"...
    4 KB (239 words) - 14:39, 6 June 2024
  • Thumbnail for North American Piedmontese
    naturally occurring gene identified as the myostatin allele mutation, or inactive myostatin gene. Myostatin prohibits muscle growth whereas an inactive...
    17 KB (1,804 words) - 04:55, 10 June 2023
  • amount of myostatin portray deficiency in muscle development and increase of fat; on the other hand, smaller than normal amounts of myostatin greatly increase...
    4 KB (383 words) - 20:49, 14 January 2024
  • Thumbnail for Whippet
    second leading cause of mortality in Whippets. A 2007 study identified a myostatin mutation particular to Whippets that is significantly associated with...
    25 KB (2,619 words) - 16:47, 25 April 2024
  • Stamulumab (category Myostatin inhibitors)
    Stamulumab (MYO-029) is an experimental myostatin inhibiting drug developed by Wyeth Pharmaceuticals for the treatment of muscular dystrophy (MD). Stamulumab...
    6 KB (524 words) - 20:14, 20 December 2023
  • Thumbnail for Gene doping
    small interfering RNA. Myostatin is a protein responsible for inhibiting muscle differentiation and growth. Removing the myostatin gene or otherwise limiting...
    32 KB (3,911 words) - 14:38, 6 June 2024
  • Thumbnail for Exercise mimetic
    ; McPherron, Alexandra C. (October 2011). "Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation". Medicine and Science in...
    4 KB (392 words) - 20:53, 2 January 2024
  • Thumbnail for Decoy receptors
    binds to myostatin, it lowers the amount of myostatin that can bind to the native receptor in the membrane (ActRIIB), preventing myostatin from delivering...
    6 KB (686 words) - 02:37, 26 February 2022
  • receptors regulate muscle growth. Myostatin, a TGF-beta superfamily member, is a negative regulator of muscle growth. Myostatin binds to ACVR2B and to a lesser...
    6 KB (583 words) - 15:40, 29 March 2023
  • Thumbnail for Transforming growth factor beta
    (Drm) LTBP1 Noggin TGIF Thrombospondin 1 (THBS1) Tomoregulin 1 Antibodies: Stamulumab (against myostatin) TRC105 (against endoglin) Others: Endoglin...
    70 KB (8,485 words) - 08:12, 19 May 2024
  • Thumbnail for Follistatin
    Follistatin (category Myostatin inhibitors)
    its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive...
    19 KB (2,169 words) - 20:45, 12 May 2024
  • Thumbnail for GDF15
    (Drm) LTBP1 Noggin TGIF Thrombospondin 1 (THBS1) Tomoregulin 1 Antibodies: Stamulumab (against myostatin) TRC105 (against endoglin) Others: Endoglin...
    12 KB (1,339 words) - 05:30, 31 March 2024
  • Eddie Hall (category People with Myostatin-related muscle hypertrophy)
    Edward Stephen Hall (born 15 January 1988) is a British media personality and retired strongman. He is best known for his world-record setting 500 kg (1...
    31 KB (2,735 words) - 04:49, 28 May 2024
  • Apitegromab (category Myostatin inhibitors)
    precursor to myostatin, which limits the size of skeletal muscle tissue, as well as inactive myostatin. It does not bind to active myostatin, activin A...
    5 KB (259 words) - 10:47, 12 November 2023
  • Thumbnail for GDF11
    to myostatin, a negative regulator of muscle growth, both structurally and phylogenetically. Though GDF11 is 90% structurally similar to myostatin, GDF11's...
    34 KB (3,974 words) - 05:29, 31 March 2024
  • may refer to: Kocher–Debré–Semelaigne syndrome Adrenogenital syndrome Myostatin mutation resulting in hypertrophy and increased strength This disambiguation...
    247 bytes (53 words) - 11:27, 18 March 2018
  • Thumbnail for 2021 in science
    to 1.2 the natural size with the same amount of food due to disabled myostatin, which inhibits muscle growth. Engineering first light of the Vera C....
    297 KB (38,840 words) - 21:47, 4 June 2024
  • Thumbnail for Activin and inhibin
    (Drm) LTBP1 Noggin TGIF Thrombospondin 1 (THBS1) Tomoregulin 1 Antibodies: Stamulumab (against myostatin) TRC105 (against endoglin) Others: Endoglin...
    26 KB (2,557 words) - 00:00, 7 March 2024
  • follicle-stimulating hormone; it also has many other systemic effects. Myocytes use myostatin to tell each other to inhibit myogenesis. Melanocyte-inhibiting factor...
    6 KB (652 words) - 09:36, 4 July 2023
  • Thumbnail for Muscle hypertrophy
    Davis' law Follistatin Lean body mass Muscle atrophy Muscle dystrophy Myostatin Pseudoathletic appearance Pseudohypertrophy Baechle TR, Earle RW, eds...
    32 KB (3,541 words) - 22:27, 14 May 2024
  • 2013). "Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB–mediated mechanism". Proceedings of the National Academy of...
    19 KB (2,139 words) - 09:24, 6 November 2023
  • Thumbnail for Genetically modified food
    the natural average size with the same amount of food due to disabled myostatin, which inhibits muscle growth. Creating genetically modified food is a...
    144 KB (15,841 words) - 13:40, 27 May 2024