Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene. The protein was identified in the laboratory...

Their homologs have been discovered in many different animal species (APAF1) and also in the plant kingdom (disease-resistance R protein). NLRs contain...

type. Knockout or inhibition of apoptotic protease activating factor 1 (APAF1), also results in malformations and increased embryonic lethality. Manipulation...

the function of each of the proteins. Several caspases, in addition to APAF1 and FADD, have been mutated to determine the new phenotype. In order to...

multimolecular holoenzyme complex assembled around the adaptor protein Apaf1 (apoptotic protease activating factor 1) upon mitochondria-mediated apoptosis...

beginning to be understood. NLRP1 has been shown to interact with caspase 9 and APAF1. Via its FIIND domain, NLRP1 interacts directly with DPP9 and DPP8 which...

found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic...

HGNC:20192 Q9H0R1 823 AP5S1 HGNC:15875 Q9NUS5 824 AP5Z1 HGNC:22197 O43299 825 APAF1 HGNC:576 O14727 826 APBA1 HGNC:578 Q02410 827 APBA2 HGNC:579 Q99767 828...

1 (CIAS1), caterpillar-like receptor 1.1 (CLR1.1), and PYRIN-containing APAF1-like protein 1 (PYPAF1). This gene encodes a pyrin-like protein which contains...

E2F7, RB1, TP107, TP21 Checkpoints: TP53, BRCA1,2, BUB1 Apoptosis: TP73, APAF1, CASP3,7,8, MAP3K5,14 Nucleotide synthesis: thymidine kinase (tk), thymidylate...

APAF1-interacting protein is a protein that in humans is encoded by the APIP gene. It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity...

Jurman M, Cao J, DiStefano PS, Bertin J (2002). "PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa...

immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species. The NWD1 gene...

Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent...

domain family, member 14 (also called CARMA2) [25][permanent dead link] APAF1: apoptotic peptidase activating factor 1 (also called CED4) [26][permanent...

is missing amino acids 1-83. Caspase-9 has been shown to interact with: APAF1 BIRC2, Baculoviral IAP repeat-containing protein 3, Caspase 8, NLRP1, and...

encoding proteins containing this domain include: AAAS, AAMP, AHI1, AMBRA1, APAF1, ARPC1A, ARPC1B, ATG16L1, BOP1, BRWD1, BRWD3, BTRC, BUB3, C6orf11, CDC20...

release of both cytochrome c and SMAC. While cytochrome c directly activates APAF1 and caspase 9, SMAC binds IAPs, such as XIAP and cIAP proteins, to inhibit...

of gene expression or inhibition of apoptotic signal pathway molecules: APAF1, Caspase 8, Bcl-2-associated X protein (bax) and Bcl-2 homologous antagonist...

proteins required for starting apoptosis, including cytochrome c, Bcl-2, APAF1, and pro-caspase-9. In 1997, his group reported the activation steps of...

apoptotic activator. BCL2-like 1 (gene) has been shown to interact with: APAF1, BAK1, BCAP31, BCL2L11, BNIP3, BNIPL, BAD, BAX, BIK, Bcl-2, HRK, IKZF3,...

M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent...

M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent...

Krajewski S, Godzik A, Reed JC (March 2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis"...

independently of the inflammasome scaffold ASC. Human Ced4 homologs include APAF1, NOD1 (CARD4), and NOD2 (CARD15). These proteins have at least 1 N-terminal...

Merriam S, Lora JM, et al. (August 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent...

GA, Grenier JM, et al. (August 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent...

M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent...

is a member of the Hsp110 family. HSPA4 has been shown to interact with: APAF1 DNAJB1, HDAC1, HSF1, HSPBP1, Histone deacetylase 2, NAD(P)H dehydrogenase...