Axin-1 is a protein that in humans is encoded by the AXIN1 gene. This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling...
17 KB (2,159 words) - 03:07, 11 July 2024
or have mutations in other genes with function similar to APC such as AXIN1, AXIN2, TCF7L2, or NKD1. Beyond the defects in the Wnt signaling pathway...
145 KB (15,781 words) - 22:45, 30 August 2024
(June 2024). "Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines". PLoS...
28 KB (3,241 words) - 04:58, 19 June 2024
attracts substantial interest in cancer research through its interaction with AXIN1 and AXIN2, which are negative regulators of pro-oncogenic β-catenin signaling...
12 KB (1,493 words) - 17:10, 2 December 2023
(June 2024). "Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines". PLOS...
88 KB (10,270 words) - 03:00, 22 June 2024
sclerosis. GSK3B has been shown to interact with: KIAA1211L ATP2A2 AKAP11, AXIN1, AXIN2, AR, CTNNB1, DNM1L, MACF1 MUC1, SMAD3 NOTCH1, NOTCH2, P53, PRKAR2A...
17 KB (1,819 words) - 16:52, 22 May 2024
schizophrenia. (29) APC (gene) has been shown to interact with: ARHGEF4, AXIN1, BUB1, CTNNB1, CSNK2B, CSNK2A1, Catenin (cadherin-associated protein), alpha...
28 KB (3,225 words) - 01:48, 6 May 2024
transcription factors, such as TCF7L2, are linked to increased susceptibility. AXIN1 GSK-3 Management of hair loss Wingless localisation element 3 (WLE3)...
64 KB (7,427 words) - 21:08, 3 August 2024
also seen in HCC, specifically CTNNB1 mutations seen in 30% of cases and AXIN1 mutations seen in 10% of cases. Mutations of genes involved in chromatin...
90 KB (10,116 words) - 18:28, 6 September 2024
heterotrimer formation. Human proteins containing this domain include: AXIN1, AXIN2 GRK1, GRK2, GRK3, GRK4, GRK5, GRK6, GRK7 RGS1, RGS2, RGS3, RGS4,...
9 KB (998 words) - 13:59, 22 June 2024
Q58HT5 1348 AWAT2 HGNC:23251 Q6E213 1349 AXDND1 HGNC:26564 Q5T1B0 1350 AXIN1 HGNC:903 O15169 1351 AXIN2 HGNC:904 Q9Y2T1 1352 AXL HGNC:905 P30530 1353...
277 KB (17 words) - 23:17, 27 April 2024
apoptosis (cell death). β-Catenin has been shown to interact with: APC, AXIN1, Androgen receptor, CBY1, CDH1, CDH2, CDH3, CDK5R1, CHUK, CTNND1, CTNNA1...
107 KB (12,362 words) - 22:48, 10 July 2024
beta-catenin. The AXIN proteins attract substantial interest in cancer research as AXIN1 and AXIN2 work synergistically to control pro-oncogenic β-catenin signaling...
11 KB (1,422 words) - 12:33, 24 December 2023
other proteins that are not a part of the TSC complex including: AKT1, AXIN1, FOXO1, GSK3B, Hsp70 Hsp90 MAPK1, PTK2, PAM, PRKAA1, RAP1A, RHEB, RPS6KA1...
16 KB (1,872 words) - 13:02, 7 July 2024
induced apoptosis proteins Cysteine-serine-rich nuclear protein 1 (AXUD1, AXIN1 up-regulated 1) 73 79 76 - 1 AGAGtga GC-Box factors SP1/GC Stimulating protein...
25 KB (1,929 words) - 15:48, 1 September 2024
shown a direct effect of Lrp5 on bone. LRP5 has been shown to interact with AXIN1. Canonical WNT signals are transduced through Frizzled receptor and LRP5/LRP6...
24 KB (3,205 words) - 21:15, 27 March 2024
been found for this gene. CSNK1E has been shown to interact with PER1 and AXIN1. Selective PF-4800567 Non-selective PF-670462 (also inhibits CK1-δ) Casein...
3 KB (450 words) - 23:00, 22 August 2021
kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1 and AXIN1. Casein kinase 1 GRCh38: Ensembl release 89: ENSG00000113712 – Ensembl,...
3 KB (340 words) - 01:58, 2 June 2024
apoptosis proteins V$CSRNP1.01 Cysteine-serine-rich nuclear protein 1 (AXUD1, AXIN1 up-regulated 1) V$STAT Signal transducer and activator of transcription...
18 KB (1,338 words) - 09:13, 10 March 2024
phosphorylate β-catenin as a result of a complex formation that includes β-catenin, AXIN1, AXIN2, APC (a tumor suppressor gene product), CSNK1A1, and GSK3B. Following...
29 KB (3,567 words) - 05:57, 10 June 2024
isoforms have been found for this gene. DVL1 has been shown to interact with: AXIN1, DVL3, EPS8, and Mothers against decapentaplegic homolog 3. Dishevelled...
11 KB (1,276 words) - 03:07, 11 July 2024
Smith DI, Ross JA, Liu W (July 2002). "Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas". Oncogene....
48 KB (6,317 words) - 19:53, 5 January 2024
regulatory subunit B56 subfamily. PPP2R5A has been shown to interact with: AXIN1, CTLA-4, PPP2CA, PPP2R1A, PPP2R1B, and PPP2R5C GRCh38: Ensembl release 89:...
11 KB (1,286 words) - 01:09, 23 December 2023
GJA8 CATSHL syndrome; 610474; FGFR3 Caudal duplication anomaly; 607864; AXIN1 Caudal regression syndrome; 600145; VANGL1 Cavernous malformations of CNS...
234 KB (18,877 words) - 15:43, 9 May 2024
between Axin1, a scaffold protein exhibiting important roles in Wnt signaling, and CK1δ/ε were fine-mapped using a peptide library. The identified Axin1 derived...
118 KB (14,740 words) - 02:59, 9 September 2024
shown to interact with PER1, PER2, CRY1, CRY2, BMAL1, CLOCK, NPAS2, and AXIN1. PER1, PER2, and BMAL1 can be directly phosphorylated by CK1ɛ, while PER3...
46 KB (5,389 words) - 00:53, 27 March 2024
Matrix score Strand CSRNP-1 Cytosine-Serine rich nuclear protein 1(AXUD1, AXIN1 up-regulated-1) 1.0 + CCAAT Box CCAAT/enhancer binding protein (C/EBP),...
20 KB (1,690 words) - 16:05, 11 August 2024
induced apoptosis proteins Cysteine-serine-rich nuclear protein 1 (AXUD1, AXIN1 up-regulated 1) 277 283 (+) 1.00 CAS interacting zinc finger protein Zinc...
14 KB (772 words) - 03:02, 22 May 2024
MAP3K1 has been shown to interact with a number of proteins, including: AXIN1, C-Raf, MAP2K1, MAPK1, Grb2, MAPK8, TRAF2, UBE2I. TAB1, TNIP1, TNIP2. Signal...
33 KB (3,167 words) - 18:40, 3 December 2023