Acid sphingomyelinase is one of the enzymes that make up the sphingomyelinase (SMase) family, responsible for catalyzing the breakdown of sphingomyelin...

treatment of non-central nervous system (CNS) manifestations of acid sphingomyelinase deficiency type A/B or type B. The most common side events include...

Niemann–Pick disease (NP), also known as acid sphingomyelinase deficiency, is a group of rare genetic diseases of varying severity. These are inherited...

such as acid sphingomyelinase, may be inhibited by lysosomally accumulated drugs. Such compounds are termed FIASMAs (functional inhibitor of acid sphingomyelinase)...

inhibitors of acid sphingomyelinase, or FIASMA, is a large group of pharmacological compounds inhibiting the enzyme acid sphingomyelinase (ASM, EC 3.1...

Sphingomyelin phosphodiesterase 1 (SMPD1), also known as acid sphingomyelinase (ASM), is an enzyme that in humans is encoded by the SMPD1 gene. Sphingomyelin...

Sphingomyelin phosphodiesterase (EC 3.1.4.12, also known as neutral sphingomyelinase, sphingomyelinase, or SMase; systematic name sphingomyelin cholinephosphohydrolase)...

(Cer) can be generated by the breakdown of sphingomyelin (SM) by sphingomyelinases (SMases), which are enzymes that hydrolyze the phosphocholine group...

histamine. Clemastine does also act as FIASMA (functional inhibitor of acid sphingomyelinase). Clemastine is rapidly absorbed from the gastrointestinal tract...

Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine". Neural Plasticity...

Acceleration Simulation Mode, a test used in automobile emissions control Acid Sphingomyelinase, an enzyme also known as Sphingomyelin phosphodiesterase 1 Activated...

produce a lysosomal enzyme called acid sphingomyelinase. Insufficient activity of the enzyme acid sphingomyelinase causes the buildup of toxic amounts...

genetically-inherited disease caused by a deficiency in the lysosomal enzyme acid sphingomyelinase, which causes the accumulation of sphingomyelin in spleen, liver...

receptors. Biperiden also acts as FIASMA (functional inhibitor of acid sphingomyelinase). The oral bioavailability is only 33 ± 5% due to extensive first-pass...

proliferation. Clofazimine is also a FIASMA (functional inhibitor of acid sphingomyelinase). Clofazimine has a biological half life of about 70 days. Autopsies...

non-sedative. Hydroxyzine also acts as a functional inhibitor of acid sphingomyelinase. Hydroxyzine can be administered orally or via intramuscular injection...

antipsychotic therapy. Benzatropine also acts as a functional inhibitor of acid sphingomyelinase (FIASMA). In veterinary medicine, benzatropine is used to treat...

a fusion protein, (1996). Acid sphingomyelinase gene and diagnosis of Niemann-Pick disease, (1997). Acid sphingomyelinase gene, (1998). Methods for the...

is complete or partial deficiency of the lysosomal enzyme called acid sphingomyelinase. In Niemann–Pick type C, the protein product of the major mutated...

death in patients with chronic visceral and chronic neurovisceral acid sphingomyelinase deficiency (NiemannPick disease type B and B variant): Literature...

There are three major pathways of ceramide generation. First, the sphingomyelinase pathway uses an enzyme to break down sphingomyelin in the cell membrane...

Chlorprothixene has also been found to act as FIASMA (functional inhibitor of acid sphingomyelinase). One metabolite of chlorprothixene is N-desmethylchlorprothixene...

Pomès, Régis; Privé, Gilbert G. (2016-07-31). "Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis"...

Chlorpromazine does also act as a FIASMA (functional inhibitor of acid sphingomyelinase). Chlorpromazine is an antagonist to H1 receptors (provoking antiallergic...

characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase". The Journal of Biological Chemistry...

SMAP1: small acidic protein SMCO4: encoding protein SMCO4 SMPD1: sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) SNHG1: encoding...

Olipudase alfa Genzyme non–central nervous system manifestations of acid sphingomyelinase deficiency Spesolimab Boehringer Ingelheim generalized pustular...

needed] Astemizole does also act as FIASMA (functional inhibitor of acid sphingomyelinase). Astemizole has been researched as a treatment for Creutzfeldt-Jakob...

Patricia; Gylys, Karen H.; Garg, Neil K. (2020-06-19). "Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's...

1016/S0022-2275(20)41485-3. PMID 7595087. Ponting CP (February 1994). "Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins...