chemical antibodies. Aptamers and antibodies can be used in many of the same applications, but the nucleic acid-based structure of aptamers, which are mostly...
60 KB (6,559 words) - 14:38, 19 June 2024
bacteria cells, metal ions, etc. Aptamers can be developed to have precise specificity to bind to a desired target. Aptamers change conformation upon binding...
28 KB (3,388 words) - 18:44, 10 July 2024
RNA therapeutics (section RNA aptamers)
utilized to select RNA aptamers, RNA aptamers can be generated for many potential targets. By directly introducing the RNA aptamers to the target during...
77 KB (8,886 words) - 09:03, 10 June 2024
Systematic evolution of ligands by exponential enrichment (section SELEX variants and alternative aptamer selection methods)
possible aptamers, is also expanded using unnatural base pairs the use of these unnatural base pairs was applied to SELEX and high affinity DNA aptamers were...
41 KB (4,741 words) - 05:07, 22 April 2024
Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA, was...
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synthetically derived RNA aptamer born out of the need for a way of studying the role of RNAs at the cellular level. This aptamer was created using Systematic...
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oligonucleotides. L-RNA aptamers are a form of aptamers. Due to their L-nucleotides, they are highly resistant to degradation by nucleases. L-RNA aptamers are considered...
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known different activity depending on enantiomeric form, Aptamers (L-ribonucleic acid aptamers): "That makes mirror-image biochemistry a potentially lucrative...
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Smart ligand (redirect from Smart aptamers)
Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed. Smart ligands can find a set...
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reported that two aptamers might bind and inhibit GPCR-AABs. The biotechnology company Berlin Cures pursued the development of the aptamer with the nucleotide...
17 KB (1,148 words) - 17:38, 23 July 2024
materials used in sensor development are molecularly imprinted polymers and aptamers. A chemical sensor array is a sensor architecture with multiple sensor...
25 KB (3,169 words) - 17:43, 16 August 2024
from nucleic acids, as in the case of aptamers, or from non-immunoglobulin protein scaffolds / peptide aptamers, into which hypervariable loops are inserted...
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usually consist of two metabolite-binding aptamer domains with similar structures in tandem. The aptamers were originally thought to cooperatively bind...
4 KB (443 words) - 20:38, 4 August 2024
immuno-RCA, the ssDNA RCA primer can be conjugated to the 3' end of a DNA aptamer as well. The primer tail can be amplified through rolling circle amplification...
24 KB (2,920 words) - 14:34, 16 July 2024
translated into protein, and cell death ensues. Tobramycin also binds to RNA-aptamers, artificially created molecules to bind to certain targets. However, there...
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2014). "Intracellular gene transcription factor protein-guided MRI by DNA aptamers in vivo". FASEB Journal. 28 (1): 464–73. doi:10.1096/fj.13-234229. PMC 3868842...
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and streptavidin proteins. DNA and other nucleic acids are the basis of aptamers, synthetic oligonucleotide ligands for specific target molecules used in...
166 KB (17,871 words) - 08:43, 15 August 2024
PMID 12351145. Babendure, Jeremy R.; Adams, Stephen R.; Tsien, Roger Y. (2003). "Aptamers Switch on Fluorescence of Triphenylmethane Dyes". Journal of the American...
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latter, aptamers generated against the target recognise it via interplay of specific non-covalent interactions and induced fitting. These aptamers can be...
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ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...
31 KB (3,430 words) - 05:24, 28 August 2024
"Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2". Biochemistry. 46 (48): 13742–51. doi:10.1021/bi7008739...
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specifically bind antigens. They consist of artificial peptides or proteins, or aptamer-based nucleic acid molecules with a molar mass of about 3 to 20 kDa. Antibody...
119 KB (13,400 words) - 17:29, 29 August 2024
Deanna; Tabrizian, Maryam; Faucher, Sebastien (2020). "Identification of two aptamers binding to Legionella pneumophila with high affinity and specificity"....
51 KB (5,373 words) - 11:44, 22 July 2024
IL-1α and the aptamer. Huang et al. uses ACE to investigate protein-protein interactions using aptamers. A α-thrombin binding aptamer was labeled with...
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or RNA sequences called aptamers. These aptamers can bind specifically to different types of CTCs. By attaching these aptamers to the channels in his microfluidic...
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PCR conditions as a reliable method to generate large amount of ssDNA aptamers". Biotechnology and Applied Biochemistry. 64 (4): 541–548. doi:10.1002/bab...
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diseases. Other potential drugs in pre-clinical development are agonist CD28 aptamers with immunostimulatory properties in a mouse tumor model, a monoclonal...
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Novartis purchased the rights to market Ophthotech's Fovista (an anti-PDGF aptamer, also being investigated for use in combination with anti-VEGF treatments)...
144 KB (12,103 words) - 22:04, 23 August 2024
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...
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engineering Thesis Identification of Malaria Parasite-Infected Red Blood Cell Aptamers by Inertial Microfluidics SELEX (2015) Doctoral advisor Jacquin Niles...
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