Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans...
61 KB (7,553 words) - 16:29, 17 August 2024
Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme...
11 KB (1,291 words) - 23:40, 16 September 2024
Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the...
14 KB (1,738 words) - 02:52, 16 December 2023
are as follows: Arachidonate 5-lipoxygenase (ALOX5) (EC 1.13.11.34; InterPro: IPR001885), also termed 5-lipoxygenase, 5-LOX, and 5-LO. Major products:...
32 KB (3,886 words) - 03:28, 23 April 2024
Leukotriene (redirect from Leukotriene-5)
essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase. Leukotrienes use lipid signaling to convey information to either...
18 KB (1,957 words) - 18:25, 30 March 2024
medication which functions as a leukotriene-related enzyme inhibitor (arachidonate 5-lipoxygenase) or leukotriene receptor antagonist (cysteinyl leukotriene receptors)...
10 KB (1,070 words) - 02:56, 18 April 2024
ALOX12 (redirect from Arachidonate 12-lipoxygenase)
13.11.31), also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans...
32 KB (3,928 words) - 09:06, 1 September 2023
Arachidonic acid (redirect from Arachidonate acid)
'peanut', although peanut oil does not contain any arachidonic acid. Arachidonate is the name of the derived carboxylate anion (conjugate base of the acid)...
21 KB (1,899 words) - 17:30, 2 October 2024
ALOX15 (redirect from Arachidonate 15-lipoxygenase-1)
ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism...
44 KB (5,708 words) - 00:43, 24 September 2024
(AEA: C 22H 37NO 2; 20:4,n−6), or its linoleoyl analogues, are by a lipoxygenase action found to be competitive inhibitors of brain and immune cell FAAH...
32 KB (2,833 words) - 06:32, 11 October 2024
agents which function as leukotriene-related enzyme inhibitors (arachidonate 5-lipoxygenase) or leukotriene receptor antagonists (cysteinyl leukotriene receptors)...
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fatty acid found primarily in seed oils. When acting on GLA, arachidonate 5-lipoxygenase produces no leukotrienes and the conversion by the enzyme of...
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in urine. Mean elimination half-life (half-life) of montelukast is 2.7 to 5.5 hours in healthy young adults. "Montelukast Sodium Monograph for Professionals"...
27 KB (2,287 words) - 07:53, 3 October 2024
co-localization of cytosolic phospholipase A2 (cPLA2), arachidonate 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTC4 synthase (LTC4S)...
7 KB (563 words) - 02:22, 11 November 2023
Zileuton (trade name Zyflo) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used...
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first mechanism involves a chain extension reaction by cinnamic acid and 5 malonyl-CoA molecules that eventually arylize into a curcuminoid. The second...
27 KB (2,415 words) - 10:54, 30 September 2024
most commonly prescribed medication in the United States, with more than 5 million prescriptions. Azelastine nasal spray is indicated for the local treatment...
17 KB (1,281 words) - 04:04, 30 September 2024
Analogue-based Drug Discovery. John Wiley & Sons. p. 467. ISBN 978-3-527-60749-5. "Captopril: Uses, Dosage, Side Effects". Drugs.com. Retrieved 2021-10-31...
22 KB (2,241 words) - 21:19, 18 October 2024
ISBN 92-4-157119-5. ISSN 0250-863X. 1991 Piscitelli SC, Rodvold K (2005). Drug Interactions in Infectious Diseases. Humana Press. ISBN 978-1-58829-455-5. Drugs...
47 KB (4,681 words) - 07:10, 1 July 2024
medication in the same class (e.g. montelukast) or in the related class of 5-lipoxygenase inhibitors can be attempted, but caution should be employed. According...
26 KB (2,484 words) - 08:02, 4 September 2024
arachidonate-5-lipoxygenase, 5-lipoxygenase, 5-LO, and 5-LOX). ALOX5 metabolizes arachidonic acid to its hydroperoxide derivative, arachidonic acid 5-hydroperoxide...
48 KB (6,107 words) - 06:42, 13 August 2024
metabolized to the 3 double bond-containing analog of 5-HETE viz., 5-HETrE (see Arachidonate 5-lipoxygenase § Mead acid). Hydroxyeicosatetraenoic acids, leukotrienes...
86 KB (9,651 words) - 06:41, 2 November 2024
inflammation, lipoxin A4 and lipoxin B4. Haeggström JZ, Funk CD (2011). "Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease"...
3 KB (160 words) - 21:43, 1 April 2024
metabolites of arachidonate 5-lipoxygenase (5-LOX): 5-hydroxyeicosatetraenoic acid (5-(S)-HETE), and its 5-keto analog 5-oxo-eicosatetraenoic acid (5-oxo-ETE)...
12 KB (1,777 words) - 01:49, 24 September 2024
bitter and acrid. The flowers are conspicuous and showy, measuring about 1.5–2.5 cm across, and are bright yellow with black dots along the edges of the...
63 KB (6,044 words) - 00:43, 3 November 2024
receptors. The flavonoid has been shown to inhibit certain types of lipoxygenases. Baicalein is an inhibitor of CYP2C9, an enzyme of the cytochrome P450...
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(2006). Biochemistry (6th ed.). San Francisco: W. H. Freeman. ISBN 0-7167-8724-5.[page needed] Erion DM, Shulman GI (2010). "Diacylglycerol-mediated insulin...
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extracts. Their reactions with amino acids and peptides". Biochem. J. 112 (5): 609–616. doi:10.1042/bj1120609. PMC 1187763. PMID 4980678. Cilliers, Johannes...
22 KB (2,017 words) - 07:43, 18 July 2024
It may perform this by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX), and may help in treating atherosclerosis...
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yielding anti-inflammatory eicosanoids, DGLA competes with AA for COX and lipoxygenase, inhibiting the production of AA's eicosanoids. Taken orally in a small...
5 KB (517 words) - 01:53, 19 July 2024