division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell...

of the spine, and actin regulators, small GTPases such as Rac, RhoA, and CDC42, rapidly modify this cytoskeleton. Overactive Rac1 results in consistently...

and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins...

CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. Cell division control protein 42 (CDC42), a small Rho GTPase, regulates...

CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene. This gene encodes a member of the serine/threonine protein...

pathways blocked. CDC42 is a small, Rho family GTPase involved in the pinching off and remodeling of the cellular plasma membrane. CDC42-regulated dynamin...

binding to a region near its N-terminus. Its activation is dependent upon CDC42 and PIP2 acting to disrupt this interaction, causing the WASp protein to...

human PAK1 was identified as a GTP-dependent interacting partner of Rac1 or Cdc42 in the cytosolic fraction from neutrophils, and its complementary DNA was...

(CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and...

cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73 Other Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting factor...

membrane and, thus, epithelial polarity. These molecules are the proteins Cdc42, atypical protein kinase C (aPKC), Par6, Par3/Bazooka/ASIP. Crumbs, "Stardust"...

Rho-type GTPase Cdc42. Specifically, Orb6 kinase spatially restricts Cdc42 activation to be at the polarized tips of a cell, causing the Cdc42-dependent formins...

Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene. The product of this gene is a member of the CDC42-binding protein...

instructions for making a protein that turns on (activates) another protein called Cdc42, which transmits signals that are important for various aspects of development...

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing...

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase...

GTPases Rac1 and Cdc42, IQGAP does not actually have GAP function. Instead, it binds the active (GTP-bound) forms of RAC1 and CDC42 with higher affinity...

and GEECs comprise the Cdc42-mediated CLIC/GEEC endocytic pathway, which is regulated by GRAF1. Each of RhoA, Arf6, or Cdc42 has the capacity to modulate...

depends upon both a Cdc42-driven positive feedback loop as well as mutual antagonism between apical and basolateral determinants. The Cdc42-driven positive...

contractile acto-myosin filaments ("stress fibers"), Rac for lamellipodia and Cdc42 for filopodia. Functions include: Muscle contraction Cell movement Intracellular...

subfamily J, member 2 (17q24.3) ACTG1: actin, gamma 1 (17q25) CDC42EP4: CDC42 effector protein 4 (17q25.1) USH1G: Usher syndrome 1G (autosomal recessive)...

globally by depleting them. The master regulator of polarity in yeast is Cdc42, which is a member of the eukaryotic Ras-homologous Rho-family of GTPases...

factor WASp and inhibits CapZ. WASp is also activated by the small GTPase Cdc42, while another nucleation promoting factor WAVE is activated by the GTPase...

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing...

influence other endocytic pathways. When CAV1 binds to Cdc42, CAV1 inactivates it and regulates Cdc42 activity during membrane trafficking events. The process...

RAC/CDC42 exchange factor, also known as GEFT, is a human gene. GEFT has been shown to interact with RHOA. GRCh38: Ensembl release 89: ENSG00000240771...

postsynaptic membrane organization steroid metabolic process regulation of Cdc42 protein signal transduction lipid metabolism negative regulation of amyloid-beta...

receptors integrins α1β1, α3β1, α4β1, α6β1 and Cdc42 GTPase are activated. The activated GTPase then activates Cdc42 which further activates c-Jun kinases and...

and Cdc42 are two Rho-family GTPases which are normally cytosolic but can also be found in the cell membrane under certain conditions. When Cdc42 is activated...

G protein-coupled receptors, which activate GTPases of the Rho family (e.g. Cdc42, Rac) via G proteins. Rho GTPases are able to activate WASp which in turn...