division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell...
31 KB (3,698 words) - 21:38, 25 March 2024
Dendritic spine (section Cdc42 pathway)
of the spine, and actin regulators, small GTPases such as Rac, RhoA, and CDC42, rapidly modify this cytoskeleton. Overactive Rac1 results in consistently...
48 KB (5,682 words) - 20:19, 21 January 2024
and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins...
25 KB (3,198 words) - 05:03, 22 June 2024
CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. Cell division control protein 42 (CDC42), a small Rho GTPase, regulates...
1 KB (194 words) - 06:01, 6 December 2022
CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene. This gene encodes a member of the serine/threonine protein...
2 KB (353 words) - 05:20, 27 March 2022
pathways blocked. CDC42 is a small, Rho family GTPase involved in the pinching off and remodeling of the cellular plasma membrane. CDC42-regulated dynamin...
17 KB (1,992 words) - 03:23, 15 July 2024
binding to a region near its N-terminus. Its activation is dependent upon CDC42 and PIP2 acting to disrupt this interaction, causing the WASp protein to...
21 KB (2,588 words) - 00:21, 5 February 2024
PAK1 (redirect from P21/Cdc42/Rac1-activated kinase 1)
human PAK1 was identified as a GTP-dependent interacting partner of Rac1 or Cdc42 in the cytosolic fraction from neutrophils, and its complementary DNA was...
43 KB (5,198 words) - 00:37, 15 June 2024
(CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and...
7 KB (954 words) - 21:12, 14 August 2023
cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73 Other Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting factor...
38 KB (4,283 words) - 20:21, 3 August 2024
membrane and, thus, epithelial polarity. These molecules are the proteins Cdc42, atypical protein kinase C (aPKC), Par6, Par3/Bazooka/ASIP. Crumbs, "Stardust"...
10 KB (1,305 words) - 22:43, 4 February 2024
Rho-type GTPase Cdc42. Specifically, Orb6 kinase spatially restricts Cdc42 activation to be at the polarized tips of a cell, causing the Cdc42-dependent formins...
3 KB (422 words) - 19:38, 18 August 2024
Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene. The product of this gene is a member of the CDC42-binding protein...
4 KB (536 words) - 19:23, 11 August 2024
instructions for making a protein that turns on (activates) another protein called Cdc42, which transmits signals that are important for various aspects of development...
9 KB (874 words) - 19:51, 23 August 2024
Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing...
4 KB (493 words) - 10:13, 10 January 2024
Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase...
14 KB (1,756 words) - 21:43, 7 November 2023
GTPases Rac1 and Cdc42, IQGAP does not actually have GAP function. Instead, it binds the active (GTP-bound) forms of RAC1 and CDC42 with higher affinity...
33 KB (3,922 words) - 20:55, 27 March 2024
and GEECs comprise the Cdc42-mediated CLIC/GEEC endocytic pathway, which is regulated by GRAF1. Each of RhoA, Arf6, or Cdc42 has the capacity to modulate...
2 KB (266 words) - 18:18, 12 May 2024
depends upon both a Cdc42-driven positive feedback loop as well as mutual antagonism between apical and basolateral determinants. The Cdc42-driven positive...
17 KB (1,798 words) - 15:49, 23 May 2024
contractile acto-myosin filaments ("stress fibers"), Rac for lamellipodia and Cdc42 for filopodia. Functions include: Muscle contraction Cell movement Intracellular...
45 KB (5,121 words) - 06:34, 27 May 2024
subfamily J, member 2 (17q24.3) ACTG1: actin, gamma 1 (17q25) CDC42EP4: CDC42 effector protein 4 (17q25.1) USH1G: Usher syndrome 1G (autosomal recessive)...
26 KB (1,916 words) - 21:48, 21 August 2024
globally by depleting them. The master regulator of polarity in yeast is Cdc42, which is a member of the eukaryotic Ras-homologous Rho-family of GTPases...
20 KB (2,554 words) - 01:41, 9 July 2024
factor WASp and inhibits CapZ. WASp is also activated by the small GTPase Cdc42, while another nucleation promoting factor WAVE is activated by the GTPase...
151 KB (18,106 words) - 19:32, 11 July 2024
Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing...
7 KB (872 words) - 20:58, 3 March 2023
influence other endocytic pathways. When CAV1 binds to Cdc42, CAV1 inactivates it and regulates Cdc42 activity during membrane trafficking events. The process...
25 KB (2,980 words) - 14:58, 19 June 2024
RAC/CDC42 exchange factor, also known as GEFT, is a human gene. GEFT has been shown to interact with RHOA. GRCh38: Ensembl release 89: ENSG00000240771...
4 KB (508 words) - 21:39, 9 March 2024
postsynaptic membrane organization steroid metabolic process regulation of Cdc42 protein signal transduction lipid metabolism negative regulation of amyloid-beta...
57 KB (6,457 words) - 05:29, 17 August 2024
receptors integrins α1β1, α3β1, α4β1, α6β1 and Cdc42 GTPase are activated. The activated GTPase then activates Cdc42 which further activates c-Jun kinases and...
12 KB (1,620 words) - 11:22, 8 October 2021
and Cdc42 are two Rho-family GTPases which are normally cytosolic but can also be found in the cell membrane under certain conditions. When Cdc42 is activated...
8 KB (775 words) - 22:38, 1 February 2024
G protein-coupled receptors, which activate GTPases of the Rho family (e.g. Cdc42, Rac) via G proteins. Rho GTPases are able to activate WASp which in turn...
16 KB (1,747 words) - 18:27, 11 March 2024