Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine...
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A catechol-O-methyltransferase inhibitor (COMT inhibitor) is a drug that inhibits the enzyme catechol-O-methyltransferase. This enzyme methylates catecholamines...
10 KB (1,107 words) - 09:34, 8 October 2024
3-O-methyldopa is produced by the methylation of L-DOPA by the enzyme catechol-O-methyltransferase. The necessary cofactor for this enzymatic reaction is s-adenosyl...
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Acetylserotonin O-methyltransferase Apigenin 4'-O-methyltransferase Caffeate O-methyltransferase Caffeoyl-CoA O-methyltransferase Catechol O-methyltransferase Chlorophenol...
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Nebicapone (redirect from 3-Nitro-5-phenylacetyl catechol)
Nebicapone (developmental code name BIA 3-202) is a catechol O-methyltransferase (COMT) inhibitor which was under development for the treatment of Parkinson's...
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cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors". CNS Drugs. 21 (7): 535–557. doi:10.2165/00023210-200721070-00002...
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include: Catechol-O-methyltransferase DNA methyltransferase Histone methyltransferase 5-Methyltetrahydrofolate-homocysteine methyltransferase O-methyltransferase...
26 KB (2,911 words) - 18:43, 22 October 2024
McClure MM, Siever LJ, Barch DM, Harvey PD (December 2007). "Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals:...
140 KB (14,868 words) - 22:30, 12 December 2024
Val/Val allele of the Rs4680 polymorphism in the gene that encodes Catechol-O-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters...
66 KB (7,189 words) - 08:33, 15 December 2024
liver but also in extrahepatic tissues, and are metabolized by catechol O-methyltransferase (COMT) into methoxylated estrogens such as 2-methoxyestradiol...
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Entacapone (category Catechol-O-methyltransferase inhibitors)
Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). When taken together with levodopa (L-DOPA) and carbidopa...
17 KB (1,519 words) - 09:29, 8 October 2024
Nitecapone (category Catechol-O-methyltransferase inhibitors)
enzyme catechol O-methyl transferase (COMT). It was patented as an antiparkinson medication but was never marketed. Catechol-O-methyltransferase inhibitor...
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Neluxicapone (redirect from C₁₆H₁₂N₂O₂)
Neluxicapone (INNTooltip International Nonproprietary Name) is a catechol O-methyltransferase (COMT) inhibitor which has not been marketed as of 2024. The...
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Opicapone (category Catechol-O-methyltransferase inhibitors)
levodopa in people with Parkinson's disease. Opicapone is a catechol-O-methyltransferase (COMT) inhibitor. The most common side effects are dyskinesia...
33 KB (1,828 words) - 14:27, 14 December 2024
Tolcapone (category Catechol-O-methyltransferase inhibitors)
potent and reversible nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase (COMT). It has demonstrated significant liver toxicity, which...
29 KB (2,997 words) - 23:59, 1 December 2024
single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase. The single nucleotide substitution between G--> A results in...
4 KB (374 words) - 04:45, 4 December 2024
Catabolism of catecholamines is mediated by two main enzymes: catechol-O-methyltransferase (COMT) which is present in the synaptic cleft and cytosol of...
20 KB (2,075 words) - 08:55, 17 July 2024
It is bound mainly to albumin. Isoprenaline is metabolized by catechol O-methyltransferase (COMT) and conjugation by sulfation. It does not appear to be...
33 KB (2,784 words) - 22:22, 24 September 2024
exon 10. Human TOMT has a predicted methyltransferase domain that is conserved with catechol-o-methyltransferase (COMT) and a single predicted transmembrane...
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4-Methoxyestradiol (redirect from 4-MeO-E2)
naturally occurring methoxylated catechol estrogen and metabolite of estradiol that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestradiol...
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4-Methoxyestrone (redirect from 4-MeO-E1)
naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestrone...
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3,4-Dihydroxyphenylacetaldehyde (category Catechols)
metabolic pathways of dopamine metabolism include methylation by catechol O-methyltransferase (COMT) into 3-methoxytyramine and β-hydroxylation by dopamine...
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Aesculetin (category Catechols)
(6-hydroxy-7-methoxycoumarin) through incubation with rat liver catechol-O-methyltransferase. Aesculetin can be synthesized by condensation of hydroxyhydroquinone...
5 KB (365 words) - 21:58, 28 January 2023
2-Hydroxyestrone (category Catechol-O-methyltransferase inhibitors)
incubated at very high concentrations or in combination with a catechol O-methyltransferase (COMT) inhibitor to prevent its metabolism, 2-hydroxyestrone...
8 KB (708 words) - 10:58, 14 August 2023
this concept is obsolete. Most polyphenols are metabolized by catechol-O-methyltransferase, and therefore do not have the chemical structure allowing antioxidant...
55 KB (5,811 words) - 04:39, 7 December 2024
inhibitor; but see more below), tolcapone (a centrally-acting catechol-O-methyltransferase (COMT) inhibitor), and amantadine (an indirectly acting dopaminergic...
93 KB (10,165 words) - 02:29, 18 December 2024
Homovanillic acid (category O-methylated phenols)
is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase on dopamine. Homovanillic acid is used as a reagent to detect...
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disease and notably of dementia-related apathy. Centrally active catechol-O-methyltransferase inhibitors (COMTIs) like tolcapone, which are likewise dopaminergic...
58 KB (6,084 words) - 07:17, 2 December 2024
diarrhea-predominant irritable bowel syndrome Entacapone – a catechol-O-methyltransferase inhibitor used in combination with levodopa in the treatment...
17 KB (1,810 words) - 17:09, 18 December 2024
Tunbridge EM, Bannerman DM, Sharp T, Harrison PJ (June 2004). "Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated...
88 KB (10,313 words) - 19:15, 16 November 2024