Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty acids from ceramide, producing...
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Farber disease (redirect from Ceramidase deficiency)
Farber disease (also known as Farber's lipogranulomatosis, acid ceramidase deficiency, "Lipogranulomatosis", and ASAH1-related disorders) is an extremely...
14 KB (1,403 words) - 15:08, 10 October 2024
ASAH1 (redirect from Acid ceramidase)
The ASAH1 gene encodes in humans the acid ceramidase enzyme. This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and...
10 KB (1,273 words) - 20:11, 7 November 2023
the generation of ceramides. Ceramide can be further hydrolyzed by acid ceramidase to form sphingosine and a free fatty acid, both of which are able to leave...
30 KB (3,361 words) - 11:32, 4 November 2024
causing buildup. Lysosomal storage diseases include: Sphingolipidoses Ceramidase Farber disease Krabbe disease Infantile onset Late onset Galactosialidosis...
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generated by this process. Finally, ceramide may be broken down by a ceramidase to form sphingosine. Sphingosine may be phosphorylated to form sphingosine-1-phosphate...
25 KB (2,774 words) - 16:47, 24 September 2024
Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. GRCh38: Ensembl release 89: ENSG00000078124...
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Rivera. The ASAH1 gene codes for acid ceramidase, an enzyme found in lysosomes. The lysosome breaks down acid ceramidase; the fatty acid component is then...
7 KB (515 words) - 16:15, 21 October 2024
Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene. ACER1 mediates cellular differentiation...
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Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene. GRCh38: Ensembl release 89: ENSG00000188611 – Ensembl, May 2017 GRCm38: Ensembl...
5 KB (687 words) - 23:03, 6 February 2024
Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme...
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N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found...
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erythrocytic Arc/Arg3.1 ASAH1: N-acylsphingosine amidohydrolase (acid ceramidase) 1 ASPH: encoding enzyme Aspartyl/asparaginyl beta-hydroxylase AZIN1:...
30 KB (1,960 words) - 23:38, 8 October 2024
SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
13 KB (811 words) - 02:32, 12 October 2024
SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
11 KB (1,140 words) - 01:30, 25 March 2024
be the generation of 5–FU. However, carmofur is a highly potent acid ceramidase (AC) inhibitor. Ceramide influences cancer cell survival, growth and death...
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SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
27 KB (2,574 words) - 15:29, 18 October 2024
Neutral ceramidase C also known as N-acylsphingosine amidohydrolase 2C or non-lysosomal ceramidase C or ASAH2C is a ceramidase enzyme which in humans is...
3 KB (333 words) - 03:58, 25 March 2022
SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
24 KB (2,392 words) - 23:10, 9 September 2024
SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
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Spencer, a Native American painter N-acylsphingosine amidohydrolase (acid ceramidase), an enzymatic product of ASAH1, gene mutated in Farber disease Australian...
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SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
14 KB (1,555 words) - 16:58, 26 October 2024
formed from ceramide, which is composed of a sphingosine and a fatty acid. Ceramidase, an enzyme primarily present in plasma membrane, will convert ceramide...
25 KB (2,659 words) - 02:02, 10 July 2024
ceramide synthases. Ceramide can also be broken down by enzymes called ceramidases, leading to the formation of sphingosine, Moreover, a phosphate group...
55 KB (5,633 words) - 08:40, 12 July 2024
SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
34 KB (3,309 words) - 16:05, 18 October 2024
PEA (N-Acylethanolamide Acid Amidase inhibitors), and ceramide (Acid Ceramidase inhibitors). Daniele Piomelli is scientific cofounder of Kadmus Pharmaceuticals...
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leukodystrophy and multiple sulfatase deficiency, and they identified acid ceramidase as the enzyme deficient in Farber's disease. In 1964, Moser returned to...
11 KB (1,239 words) - 03:27, 9 October 2024
SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
11 KB (798 words) - 20:58, 10 October 2024
SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
12 KB (1,266 words) - 08:05, 18 August 2023
Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. The ACER2/sphingosine pathway plays an important...
3 KB (394 words) - 13:16, 24 January 2024