The class C G-protein-coupled receptors (InterPro: IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors...
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G protein-coupled receptor (redirect from GPCR)
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors...
82 KB (9,384 words) - 18:56, 11 June 2024
Secretin receptor family (redirect from Class B GPCR)
Secretin receptor family (class B GPCR subfamily) consists of secretin receptors regulated by peptide hormones from the glucagon hormone family. The family...
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5-HT2B, the second HIV co-receptor, C-C chemokine receptor type 5 (CCR5) and the first structure of a non-class A GPCR, the transmembrane domain of the human...
39 KB (5,656 words) - 00:13, 28 January 2024
A GPCR oligomer is a protein complex that consists of a small number (ὀλίγοι oligoi "a few", μέρος méros "part, piece, component") of G protein-coupled...
15 KB (1,538 words) - 01:25, 21 April 2024
Adhesion G protein-coupled receptor (redirect from Adhesion gpcr)
Adhesion G protein-coupled receptors (adhesion GPCRs) are a class of 33 human protein receptors with a broad distribution in embryonic and larval cells...
30 KB (3,499 words) - 22:35, 29 March 2024
Rhodopsin-like receptors (redirect from Rhodopsin-like GPCR)
known superfamily members include the rhodopsin-like GPCRs (this family), the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors...
25 KB (2,172 words) - 01:01, 29 November 2023
receptors (GPCRs) that span the cell membrane. Signaling molecules bind to a domain of the GPCR located outside the cell, and an intracellular GPCR domain...
24 KB (2,754 words) - 20:56, 30 July 2024
ligand binding cleft. In contrast to the conservative structure of other class C GPCR receptors, the CaSR cleft is an allosteric or co-agonist binding site...
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Class GPCRs". IUPHAR/BPS Guide to PHARMACOLOGY Database. University of Edinburgh / International Union of Basic and Clinical Pharmacology. "Class C Orphans...
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a cysteine-rich domain (CRD). The canonical activation mechanism of class C GPCRs follows a multiple-step process that requires communication between...
13 KB (1,609 words) - 02:24, 29 November 2023
GPR156 were characterized by using cryogenic electron microscopy. Among class C GPCR family members, GPR156 is unique because it lacks a large extracellular...
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glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It is involved...
33 KB (4,071 words) - 15:36, 30 July 2024
acid receptor 1 (HCA1), which is a Gi/o-coupled G protein-coupled receptor (GPCR). In industry, lactic acid fermentation is performed by lactic acid bacteria...
39 KB (4,182 words) - 11:21, 15 August 2024
receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane...
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protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing...
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activation. The term "protein kinase C" usually refers to the entire family of isoforms. The different classes of PKCs found in jawed vertebrates originate...
27 KB (2,716 words) - 18:23, 1 August 2024
The GPCR superfamily is the largest gene family in the human genome containing approximately 800 genes. As the vertebrate superfamily can be phylogenetically...
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inhibits the activity of the carrier molecule, Na-K-ATPase pump. The widest class of drugs act as ligands that bind to receptors that determine cellular effects...
19 KB (2,225 words) - 21:08, 29 May 2024
receptors (GPCRs). Neuropeptide-GPCRs fall into two families: rhodopsin-like and the secretin class. Most peptides activate a single GPCR, while some...
21 KB (2,317 words) - 13:08, 8 July 2024
pathways, such as β-arrestin signaling. In addition to GPCRs, arrestins bind to other classes of cell surface receptors and a variety of other signaling...
16 KB (1,647 words) - 04:47, 2 December 2023
vertebrates, these receptors are members of the class A rhodopsin-like family of G protein-coupled receptors (GPCRs). The olfactory receptors form a multigene...
36 KB (4,350 words) - 07:43, 3 June 2024
on-off switch for the activation of G-protein. When ligands bind a GPCR, the GPCR acquires GEF (guanine nucleotide exchange factor) ability, which activates...
13 KB (1,237 words) - 18:10, 26 April 2024
Retrieved 8 December 2020. Congreve M, Marshall F (March 2010). "The impact of GPCR structures on pharmacology and structure-based drug design". British Journal...
26 KB (2,672 words) - 14:14, 22 July 2024
G-protein coupled receptors (GPCR), and membrane fluidity have all been shown to be affected by steroid hormones. Of these, GPCR linked proteins are the most...
15 KB (1,674 words) - 02:59, 22 February 2024
Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends in Pharmacological Sciences. 26 (5): 274–281. doi:10.1016/j...
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protein-coupled receptor (GPCR) that regulates brain catecholamine systems. Activation of TAAR1 increases cyclic adenosine monophosphate (cAMP) production and...
151 KB (14,842 words) - 09:53, 16 August 2024
the cAMP signal pathway and the phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which...
16 KB (1,590 words) - 01:49, 26 October 2023
receptor-ligand system. These systems typically utilize G protein-coupled receptors (GPCR) engineered to respond exclusively to synthetic ligands, like clozapine N-oxide...
17 KB (1,944 words) - 19:49, 3 December 2023
GPCR neuropeptide receptors are G-protein coupled receptors which bind various neuropeptides. Members include: Neuropeptide B/W receptor NPBWR1 NPBWR2...
3 KB (262 words) - 15:50, 18 February 2024