A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a...

to the lac promoter. CRISPR activation Bacterial transcription Coactivator (genetics) Eukaryotic transcription Glossary of gene expression terms Operon...

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is...

structure remodeling complex ISWI protein SMARCA1, SMARCA2 Coactivator (genetics) Corepressor (genetics) Nuclear receptor coregulators RNA polymerase control...

1038/nrg2322. PMID 18319743. S2CID 690431. Shoag J; et al. (Jan 2013). "PGC-1 coactivators regulate MITF and the tanning response". Mol Cell. 49 (1): 145–157. doi:10...

In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription...

In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the...

The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators): p300 (also called...

Both of these related proteins, prototypical members of the p300-CBP coactivator family, have a bromodomain and a histone acetyltransferase domain and...

transcriptional coregulator, is essential for cell function because as a coactivator at a significant number of promoters, it activates the transcription...

polymerase and other transcription machinery in the same region. See also coactivator; contrast repressor. active site The region of an enzyme to which one...

agonist) AF-2 binds either the N-terminal FXXFL motif intramolecularly or coactivator proteins (containing the LXXLL or preferably FXXFL motifs) A ligand dependent...

Mediator is a multiprotein complex that functions as a transcriptional coactivator. The Mediator complex is required for the successful transcription of...

that exhibit HAT activity. These include p300/CBP, nuclear receptor coactivators (e.g., ACTR/SRC-1), TAFII250, TFIIIC, Rtt109, and CLOCK. p300/CBP are...

domain. Cleavage by kallikrein also helps HMWK to optimally function as a coactivator. The cleavage results in a change in the conformation of HMWK that may...

ligand-binding domain (see below) induced by ligand binding and by a number of coactivator and corepressor proteins, the presence of which can stimulate or inhibit...

intermittent hyperventilation (Pitt-Hopkins syndrome)". American Journal of Human Genetics. 80 (5): 994–1001. doi:10.1086/515583. PMC 1852727. PMID 17436255. Whalen...

to the dimerization interface of the receptor and in addition, binds coactivator and corepressor proteins. The LBD also contains the activation function...

Rosenfeld MG (April 1999). "Coactivator and corepressor complexes in nuclear receptor function". Current Opinion in Genetics & Development. 9 (2): 140–7...

characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". The Journal...

is an ongoing area of research. KMT2A gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early...

corepressors and in the presence of coactivators, transcription factors upregulate gene expression. Coactivators and corepressors compete for the same...

interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". The Journal of Biological Chemistry. 272 (18): 12062–8. doi:10...

the zebrafish restores normal development. MED12 is also a critical coactivator for the gene SOX9, which is involved in the developmental regulation...

not be corrected by supplementation with any coactivators known at the time, nor was the absent coactivator protein characterized, which left some in the...

or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3....

(October 2004). "Biological control through regulated transcriptional coactivators". Cell. 119 (2): 157–67. doi:10.1016/j.cell.2004.09.037. PMID 15479634...

of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain...

transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein". The Journal of Biological Chemistry. 275 (22):...

and silencers. The LCR functions by recruiting chromatin-modifying, coactivator, and transcription complexes. Its sequence is conserved in many vertebrates...