CpG island hypermethylation is a phenomenon that is important for the regulation of gene expression in cancer cells, as an epigenetic control aberration...

along its 5' → 3' direction. CpG sites occur with high frequency in genomic regions called CpG islands. Cytosines in CpG dinucleotides can be methylated...

histology. Aneuploidy, ranging from haploidy to tetraploidy, and CpG island hypermethylation have also been shown to be frequent and associated with survival...

K, Chirico G, Cassingena A, Rusconi F, Esposito A, Nichelatti M, Esteller M, Siena S (April 2013). "Promoter CpG island hypermethylation of the DNA repair...

studied DNA methylation dysregulation is the promoter hypermethylation where the CPGs islands in the promoter regions are methylated contributing or...

Moutinho C, Belotti A, Bencardino K, Chirico G, et al. (April 2013). "Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical...

Bencardino K, Chirico G, Cassingena A, Rusconi F, Esposito A, Nichelatti M, Esteller M, Siena S (2013). "Promoter CpG island hypermethylation of the DNA repair...

colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores". Nature Genetics. 41 (2): 178–186. doi:10...

frequently by transcription silencing (caused by promoter hypermethylation of CpG islands) than by mutations. As Vogelstein et al. point out, in a colorectal...

synthesis. It also typically contains CpG islands, a TATA box, and TFIIB recognition elements. Hypermethylation downregulates both genes, while demethylation...

EH3 due to this hypermethylation may contribute to the onset and/or progression of prostate cancer. Similar CpG site hypermethylations in the promoter...

due to promoter hypermethylation may contribute to the onset and/or progression of prostate cancer. Similar CpG site hypermethylations in the promoter...

Kuwabara Y, et al. (2002). "Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer". Carcinogenesis. 23 (10): 1695–9. doi:10...

by transcription silencing (caused by epigenetic promoter hypermethylation of CpG islands) than by mutations. As Vogelstein et al. points out, in a colorectal...

ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma". World J. Gastroenterol...

methylation of CpG sites seems to be the default. Human DNA has about 80–90% of CpG sites methylated, but there are certain areas, known as CpG islands, that are...

Ghani M, Dib S, Keith J, Robertson J, Rogaeva E (June 2013). "Hypermethylation of the CpG island near the G4C2 repeat in ALS with a C9orf72 expansion". American...

twenty years ago identified the concept of CpG island methylator phenotype (CIMP) or CpG island hypermethylation in colorectal cancer. This concept of CIMP...

Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in...

cells, hypermethylation of a CpG island immediately upstream of the YPEL3 promoter has been seen to down regulate YPEL3 expression. Hypermethylation seen...

(forming 5-methylCpG or 5-mCpG). However, unmethylated cytosines within 5'cytosine-guanine 3' sequences often occur in groups, called CpG islands, at active...

results of analysis of 630 human primary tumors for WRN CpG island hypermethylation. This hypermethylation caused reduced protein expression of WRN, a common...

transcription silencing (caused, for example, by promoter hypermethylation of CpG islands) than by mutations. As Vogelstein et al. point out, in a colorectal...

suppressor TIG1." Structure 13(2), 309–317, 2005. Cho et al.: "Hypermethylation of CpG island loci and hypomethylation of LINE-1 and Alu repeats in prostate...

methyltransferase enzymes on cytosine nucleotides in a CpG dinucleotide sequence (also called "CpG islands" when densely clustered). Analysis of the pattern...

cancer and various developmental diseases. For example, hypermethylation at the promoter CpG islands of a tumour suppressor gene, which in turn leads to its...

Analysis shows that the MORT gene expression is silenced by DNA hypermethylation of its CpG island promoter in a majority of human tumor samples in 15 of these...

become both overly methylated, termed hypermethylation, and under-methylated, termed hypomethylation. CpG islands overlapping gene promoters are de novo...

expression, the less collagen is produced. In SSc patients, hypermethylation of CpG islands in the Fli1 promoter region is observed, inhibiting transcription...

enzymes and bisulfite sequencing to enrich for areas of the genome with a high CpG content. Due to the high cost and depth of sequencing to analyze methylation...