DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, is an enzyme that plays a crucial role in repairing DNA double-strand breaks and...
32 KB (3,754 words) - 05:22, 30 September 2024
one DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA ends to enable the binding of Artemis protein to one end of each DNA-PKcs. One...
43 KB (5,681 words) - 00:50, 14 June 2024
Winters TA, Georgakilas AG (2010). "DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells". Free...
42 KB (3,756 words) - 04:23, 25 March 2024
Topoisomerase (redirect from Dna topoisomerases)
components of the non-homologous end joining DNA repair pathway, including DNA-PKcs, Ku70/Ku80 and DNA ligase IV assembled with topo IIβ and PARP-1....
57 KB (6,173 words) - 00:11, 11 December 2023
Winters TA, Georgakilas AG (2010). "DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells". Free...
97 KB (11,101 words) - 11:45, 3 September 2024
Double-strand break repair model (category DNA repair)
recruitment of various NHEJ factors, such as the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), DNA Ligase IV and X-ray cross complementing protein...
34 KB (4,130 words) - 03:55, 5 August 2024
Non-homologous end joining (category DNA repair)
forms a complex with DNA-PKcs, which is present in mammals but absent in yeast. Ku is a basket-shaped molecule that slides onto the DNA end and translocates...
28 KB (3,683 words) - 04:20, 22 August 2024
2004). "Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice". EMBO Reports. 5 (5): 503–09. doi:10.1038/sj.embor.7400127...
129 KB (15,900 words) - 06:12, 13 August 2024
Artemis (protein) (section Repair of DNA breaks)
combined immunodeficiency (SCIDA). DCLRE1C has been shown to interact with DNA-PKcs. GRCh38: Ensembl release 89: ENSG00000152457 – Ensembl, May 2017 GRCm38:...
14 KB (1,840 words) - 18:48, 24 January 2024
Klaus; Lieber, Michael (2005). "The Artemis:DNA-PKcs Endonuclease Cleaves DNA Loops, Flaps, and Gaps". DNA Repair. 4 (7): 845–851. doi:10.1016/j.dnarep...
21 KB (2,857 words) - 20:56, 28 September 2024
Christopher; Jones, Jennifer K.; Aytes, Alvaro; Magee, Michael S. (2015-07-13). "DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression...
13 KB (1,450 words) - 12:14, 9 November 2023
there is a DNA test to determine if a given horse is a carrier of the allele. The only known form of horse SCID involves mutation in DNA-PKcs. Unlike SCID...
11 KB (1,429 words) - 01:31, 14 August 2024
Sirtuin 6 (section DNA repair)
DNA double-strand breaks by the process of non-homologous end joining and homologous recombination. SIRT6 stabilizes the repair protein DNA-PKcs (DNA-dependent...
8 KB (1,028 words) - 03:08, 16 May 2023
Nuclease (section DNA repair)
reaction. Although Artemis exhibits 5' → 3' ssDNA exonuclease activity when alone, its complexing with DNA-PKcs allows for endonucleasic processing of the...
22 KB (2,538 words) - 13:28, 11 September 2024
(PI3Ks). This protein kinase family includes ATR (ATM- and RAD3-related), DNA-PKcs (DNA-dependent protein kinase catalytic subunit) and mTOR (mammalian target...
50 KB (5,684 words) - 01:04, 3 October 2024
lamin A, lamin B1, lamin B2, PARP (poly ADP ribose polymerase), and DNA-PKcs (DNA-activated protein kinase). The final result is apoptosis of the cell...
31 KB (3,843 words) - 10:18, 12 August 2024
the 469 kDa DNA-dependent protein kinase (DNA-PKcs) to gain endonuclease activity on hairpins and the 5' and 3' overhangs; the DNA-PKcs phosphorylates...
3 KB (467 words) - 14:59, 15 March 2022
Severe combined immunodeficiency (category DNA replication and repair-deficiency disorders)
Esguerra, Z; Watanabe, G; Okitsu, CY; Hsieh, CL; Lieber, MR (April 2020). "DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair...
34 KB (3,270 words) - 01:33, 14 August 2024
Memory (section DNA methylation and demethylation)
enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80, and DNA LIGASE IV) (see Figure). These enzymes repair the...
134 KB (16,666 words) - 12:05, 9 October 2024
four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see figure). These enzymes repair the double-strand...
26 KB (2,836 words) - 19:47, 1 August 2024
inhibitors target proteins (PARP family) and kinases (ATM, DNA-PKCs) that are involved in DNA repair. Indirect inhibitors target protein tumor cell signaling...
25 KB (3,218 words) - 19:35, 11 October 2024
P53 (section DNA damage and repair)
CEBPZ, CDC14A, Cdk1, CFLAR, CHEK1, CCNG1, CREBBP, CREB1, Cyclin H, CDK7, DNA-PKcs, E4F1, EFEMP2, EIF2AK2, ELL, EP300, ERCC6, GNL3, GPS2, GSK3B, HSP90AA1...
124 KB (13,220 words) - 11:01, 30 August 2024
Werner syndrome (category DNA replication and repair-deficiency disorders)
depends on DNA, it is only functional when localized to the nucleus.[citation needed] The finding that WRN protein interacts with DNA-PKcs and the Ku...
36 KB (4,516 words) - 22:47, 23 September 2024
DCLRE1C (Artemis) deficiency XLF (protein)/Cernunnos deficiency DNA PKcs deficiency DNA ligase type IV deficiency adenosine deaminase (ADA) deficiency...
19 KB (1,836 words) - 09:52, 5 July 2024
four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand...
52 KB (6,235 words) - 15:49, 26 April 2024
Ku80 (redirect from ATP-dependent DNA helicase 2 subunit 2)
different DNA repair proteins that are epigenetically repressed in various cancers (see Cancer epigenetics). Ku80 has been shown to interact with: DNA-PKcs, GCN5L2...
21 KB (2,612 words) - 05:45, 11 June 2024
Ku (protein) (category DNA repair)
forms a complex with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to form the full DNA-dependent protein kinase, DNA-PK. Ku is thought to...
15 KB (1,695 words) - 15:03, 17 January 2023
although it can also inhibit other PI3K-related enzymes such as mTOR, DNA-PKcs, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK)...
12 KB (1,138 words) - 05:28, 7 May 2024
ADP-ribosylation (section DNA repair)
PARP1. The PARPs have many protein targets at the site of DNA damage. KU protein and DNA-PKcs are both double-stranded break repair components with unknown...
29 KB (3,535 words) - 13:23, 4 January 2024
repair proteins. ETS1 binds with DNA-dependent protein kinase (DNA-PK) [where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku (protein), and where...
13 KB (1,811 words) - 03:47, 21 August 2023