receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested that dopamine receptors...

(MSNs) containing mainly D1-type (i.e., DRD1 and DRD5) or D2-type (i.e., DRD2, DRD3, and DRD4) dopamine receptors. A subpopulation of MSNs contain both...

No Yes Altered striatal dopamine signaling ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD2 ↑DRD2 Altered striatal opioid signaling No change...

dopamine receptor D2 (DRD2) signaling (increased DRD2 density) to those induced by pathological stimulant use (decreased DRD2 density). Consequently...

neurotransmission. The DRD2 Gene results in humans finding seemingly rewarding paths such as drug abuse. Through studies, DRD2 seems to be a risk factor...

located in the promoter region of the DRD2 gene, since the polymorphism is proximal to the DRD2 gene and can influence DRD2 receptor expression. It is now known...

intracellular levels of cAMP by activating adenylate cyclase. D5 DRD5 D2-like D2 DRD2 Gi-coupled. Decrease intracellular levels of cAMP by inhibiting adenylate...

No Yes Altered striatal dopamine signaling ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD2 ↑DRD2 Altered striatal opioid signaling No change...

No Yes Altered striatal dopamine signaling ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD2 ↑DRD2 Altered striatal opioid signaling No change...

enzyme adenylyl cyclase. D2 is encoded by the Dopamine receptor D2 gene (DRD2), of which there are two forms: D2Sh (short) and D2Lh (long): The D2Sh form...

found to be present more often in those bearing the TaqI A1 allele of the DRD2 3' UTR sequence and the overlapping ANKK1 exon 8. This allele has been proposed...

dopamine receptor D2 (DRD2) density in the striatum. This is the opposite of pathological stimulant use, which induces decreased striatal DRD2 density. One review...

substance abuse, as well as neurological problems.[citation needed] The DRD2 gene regulates dopamine[citation needed] to which any mutation in this gene...

polymorphism is a synonymous mutation located within the 957th base pair of the DRD2 gene. This base pair is located in exon 7. Most synonymous mutations are...

neurons express D2-type dopamine receptors, adenosine A2A receptors (A2A), DRD2–A2A heterotetramers, and enkephalin. Both types express glutamate receptors...

No Yes Altered striatal dopamine signaling ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD2 ↑DRD2 Altered striatal opioid signaling No change...

dopamine receptor D2 (DRD2) density in the striatum. This is the opposite of pathological stimulant use, which induces decreased striatal DRD2 density. One review...

dopamine receptor D2 (DRD2) density in the striatum. This is the opposite of pathological stimulant use, which induces decreased striatal DRD2 density. One review...

receptors, with approximately 40% of striatal MSNs expressing both DRD1 and DRD2 mRNA. Cholinergic interneurons release acetylcholine, which has a variety...

RD5 DRD5 DRD5 DRD5 10 RD4 DRD4 DRD4 DRD4 11 RD3 DRD3 DRD3 DRD3 12 RD2 DRD2 DRD2 DRD2 13 RD1 DRD1 DRD1 DRD1 14 RD0 DRD0 DRD0 DRD0 Data Bus 16 bit, bit 0 15...

Genetic variants (such as the DRD4 7R allele, as well as others on DRD4 and DRD2) conferring susceptibility to ADHD are very frequent—implying that the trait...

the phenothiazine class. It is an antagonist of dopamine receptors (DRD1, DRD2, DRD4) as well as of 5-HT2A, 5-HT2C receptors, mAChRs (1 through 5), α1 adrenergic...

No Yes Altered striatal dopamine signaling ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD1, ↓DRD2, ↑DRD3 ↑DRD2 ↑DRD2 Altered striatal opioid signaling No change...

Dopamine receptor D2 Identifiers Symbol DRD2 NCBI gene 1813 HGNC 3023 OMIM 126450 RefSeq NP_000786 UniProt P14416 Other data Locus Chr. 11 q22...

however, mothers possessing the short allele of the dopamine receptor gene DRD2 were more likely to be divorced, separated, or never married. Moreover, their...

neurotransmitter receptors: somatostatin receptor 5, dopamine receptor type 2 (DRD2), melanocortin-3 receptor (MC3R), and serotonin receptor type 2C (5-HT2c...

Nuclear pore Nuclear membrane Plasma membrane Cav1.2 NMDAR AMPAR DRD1 DRD5 DRD2 DRD3 DRD4 Gs Gi/o AC cAMP cAMP PKA CaM CaMKII DARPP-32 PP1 PP2B CREB ΔFosB...

N. (2010). "Brief communication: Allelic and haplotypic structure at the DRD2 locus among five North Indian caste populations". American Journal of Physical...

Bhatia T, Deshpande SN, Thelma BK (October 2020). "The effect of rs1076560 (DRD2) and rs4680 (COMT) on tardive dyskinesia and cognition in schizophrenia subjects"...

2007;90(1-3):115-22. Liou YJ, Lai IC, Liao DL, et al. The human dopamine receptor D2 (DRD2) gene is associated with tardive dyskinesia in patients with schizophrenia...