Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that contains the pyrimidine base cytosine. The triphosphate group contains high-energy...
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Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate, with the -OH (hydroxyl)...
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Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans. dCK predominantly phosphorylates deoxycytidine (dC) and converts dC...
21 KB (2,519 words) - 01:02, 3 December 2023
nucleoside diphosphate kinase can phosphorylate into cytidine triphosphate or deoxycytidine triphosphate. Phosphoribosyltransferases add activated ribose-5-phosphate...
7 KB (736 words) - 10:22, 12 August 2024
triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. Deoxyadenosine triphosphate is...
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active as gemcitabine triphosphate (dFdCTP). After being thrice phosphorylated, gemcitabine can masquerade as deoxycytidine triphosphate and is incorporated...
26 KB (2,420 words) - 15:49, 26 June 2024
deoxynucleotide concentrations, including deoxycytidine triphosphate. Gemcitabine triphosphate competes with deoxycytidine triphosphate for incorporation into DNA....
60 KB (6,590 words) - 06:01, 15 September 2024
azacitidine have been metabolized to 5-aza-2′-deoxycytidine-triphosphate (aka, decitabine-triphosphate), they can be incorporated into DNA and azacytosine...
20 KB (1,915 words) - 00:12, 31 March 2024
polymerase and "rotating the template guanine," which prevents deoxycytidine triphosphate (dCTP) from binding. This S phase block induces apoptosis in HeLa...
27 KB (3,275 words) - 08:57, 2 November 2024
adenosine triphosphate or guanosine triphosphate donating the phosphate group. Since cytidine triphosphate is generated by amination of uridine triphosphate, the...
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class is dCTP aminohydrolase. Other names in common use include deoxycytidine triphosphate deaminase, and 5-methyl-dCTP deaminase. This enzyme participates...
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Arabinofuranosylcytosine triphosphate is a nucleotide that inhibits the synthesis of DNA by acting as an antimetabolic agent against deoxycytidine (a component of...
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DNA polymerase (redirect from Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed))
enzymes that catalyze the synthesis of DNA molecules from nucleoside triphosphates, the molecular precursors of DNA. These enzymes are essential for DNA...
59 KB (7,090 words) - 06:49, 30 June 2024
pyrimidine metabolism. Zimmerman SB, Kornberg A (May 1961). "Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Eschrichia...
2 KB (129 words) - 13:44, 26 August 2023
cells via hENT1, hENT2, and hCNT2, where upon it is phosphorylated by deoxycytidine kinase to generate clofarabine-5´-monophosphate. The rate-limiting step...
11 KB (926 words) - 07:57, 25 September 2023
1 is an enzyme that in humans is encoded by the DCTPP1 gene. Deoxycytidine triphosphate (dCTP) Transactivation GRCh38: Ensembl release 89: ENSG00000179958...
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by hENT-1. It is then monophosphorylated by deoxycytidine kinase and eventually cytarabine-5´-triphosphate, which is the active metabolite being incorporated...
19 KB (1,757 words) - 09:15, 29 October 2024
analog of pyrimidine. It is a derivative of the naturally existing deoxycytidine, made by replacing the hydroxyl group in position 3' with a hydrogen...
11 KB (1,054 words) - 16:44, 29 September 2024
required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic...
39 KB (3,730 words) - 07:40, 30 September 2024
a synthetic pyrimidine nucleoside analogue, structurally related to deoxycytidine, in which the 3´-hydroxyl group of the ribose sugar moiety is substituted...
33 KB (3,234 words) - 06:11, 2 November 2024
Once inside a cell, cladribine undergoes phosphorylation by the enzyme deoxycytidine kinase (DCK) to produce mononucleotide 2-chlorodeoxyadenosine 5’monophosphate...
43 KB (4,492 words) - 00:15, 27 August 2024
deoxycytidylate kinase, CMP kinase, CTP:CMP phosphotransferase, dCMP kinase, deoxycytidine monophosphokinase, UMP-CMP kinase, ATP:UMP-CMP phosphotransferase, and...
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lymphomas, is converted into cytosine arabinoside triphosphate by deoxycytidine kinase. Mutation of deoxycytidine kinase or loss of expression results in resistance...
35 KB (3,844 words) - 23:17, 21 July 2024
symbol U or Ura uridine symbol U or Urd deoxyuridine symbol dU or dUrd cytosine symbol C or Cyt cytidine symbol C or Cyd deoxycytidine symbol dC or dCyd...
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carbon of a ribose sugar. Cytosine bonded to deoxyribose is known as deoxycytidine, which is the version used in DNA. cytochemistry The branch of cell...
315 KB (29,380 words) - 23:23, 22 October 2024
generated interest as a potential glutamatergic antidepressant drug. Deoxycytidine is cytosine attached to a deoxyribose. William M. Haynes (2016). CRC...
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MILLIMOLAR) 9icr: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DCTP AND MNCL2 9ics: DNA POLYMERASE...
19 KB (2,214 words) - 09:45, 23 December 2023
246.400 – cytidine triphosphate MeSH D13.695.740.246.425 – deoxycytosine nucleotides MeSH D13.695.740.246.425.300 – deoxycytidine monophosphate MeSH D13...
42 KB (3,875 words) - 18:21, 20 June 2023
M, Degan P, et al. (March 2010). "Defective repair of 5-hydroxy-2'-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli...
91 KB (9,992 words) - 04:35, 30 October 2024
Thd + ATP → TMP + ADP where Thd is (deoxy)thymidine, ATP is adenosine triphosphate, TMP is (deoxy)thymidine monophosphate and ADP is adenosine diphosphate...
103 KB (11,263 words) - 15:52, 2 November 2024