Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of the endocytic membrane transport pathway originating...

slow manner. The trophozoite has a single nucleus, prominent for nuclear endosome and many cytoplasmic vacuoles. The ectoplasm and the granular endoplasm...

back to the surface (as in early endosomes and recycling endosomes), or sort them to degradation (as in late endosomes and lysosomes). The principal components...

encodes for the 1400 amino acid protein, Early Endosome Antigen 1. EEA1 localizes exclusively to early endosomes and has an important role in endosomal trafficking...

pH 6.5–6.7. The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport. Enzyme replacement therapy (ERT) for several...

HLA-DMB. HLA-DM is a molecular chaperone that works in lysosomes and endosomes in cells of the immune system. It works in APCs like macrophages, dendritic...

vesicles called endosomes. There are three compartments involved in this antigen presentation pathway: early endosomes, late endosomes or endolysosomes...

the stack, but can also be separate from it. The TGN may act as an early endosome in yeast and plants. There are structural and organizational differences...

between the Golgi and plasma membrane, the Golgi and endosomes and the plasma membrane and endosomes. COPI coated vesicles are responsible for retrograde...

entry into the host cell within an endosome. Once the virus has successfully gained entry into the host cell, the endosome acidifies, which alters virus topology...

sortilin functions in protein transport between the Golgi apparatus, endosome, lysosome, and plasma membrane, leading to its involvement in multiple...

the cell to internalize the toxin within an endosome via receptor-mediated endocytosis. Inside the endosome, DT is split by a trypsin-like protease into...

Shandala T, Weigert R, Butler LM, Brooks DA (December 2014). "Altered endosome biogenesis in prostate cancer has biomarker potential". Molecular Cancer...

during the receptor's repeated trips to the highly acidic interior of the endosome. The exact mechanism of interaction between the class A repeats and ligand...

receptors bound to LDL are delivered to the endosome. In the presence of low pH, such as that found in the endosome, LDL receptors undergo a conformation change...

component membrane cell surface integral component of membrane recycling endosome intracellular anatomical structure integral component of plasma membrane...

dissociate. What is left is known as an early endosome. The early endosome merges with a late endosome. This is the vesicle that allows the particles...

virus into the cell by way of an endosome. The virus then uses the acidic environment, which is necessary, of that endosome and binds to its membrane simultaneously...

vesicle that then uncoats of clathrin and typically fuses to a sorting endosome. Once fused, the endocytosed cargo (receptor and/or ligand) can then be...

AA, Voeltz GK (6 February 2013). "Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature". Molecular Biology of the Cell. 24...

the endosome. Once formed, the endosome combines with a structure known as a multivesicular body (MVB). The MVB containing segregated endosomes ultimately...

a process in which ubiquitin-tagged proteins enter organelles called endosomes via the formation of vesicles. This process is essential for cells to...

vesicle with the membrane, followed by recycling, or recycling into the endosome. Vesicular fusion is driven largely by the concentration of calcium in...

receptor binding Cellular component early endosome chylomicron remnant vesicle lumen endoplasmic reticulum endosome membrane mature chylomicron endoplasmic...

Alzheimer’s patients. Retromer regulates protein trafficking from the early endosome either back to the trans-Golgi (retrograde) or back to the plasma membrane...

inside the cell. These pinocytotic vesicles then typically fuse with early endosomes to hydrolyze (break down) the particles.[citation needed] Pinocytosis...

localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to early endosomes. It drives the maturation...

membrane exchange system and are formed by a gradual maturation process from endosomes. The production of lysosomal proteins suggests one method of lysosome...

fuse to endosomes in order to release their content. There are three main compartments that have endosome trafficking: Golgi to/from endosomes; plasma...

Ira Mellman is an American cell biologist who discovered endosomes. He served as Vice President of Research Oncology at Genentech in South San Francisco...