nuclear estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs)...
35 KB (3,818 words) - 03:47, 30 July 2024
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a...
58 KB (6,133 words) - 05:31, 13 July 2024
they bind to and activate estrogen receptors (ERs) which in turn modulate the expression of many genes. Additionally, estrogens bind to and activate rapid-signaling...
73 KB (7,782 words) - 14:21, 7 August 2024
Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonists/antagonists (ERAAs), are a class of drugs that act on estrogen receptors...
55 KB (6,371 words) - 17:41, 14 August 2024
Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear...
39 KB (4,526 words) - 06:00, 25 July 2024
Antiestrogen (redirect from Estrogen receptor antagonists)
effects in the body. They act by blocking the estrogen receptor (ER) and/or inhibiting or suppressing estrogen production. Antiestrogens are one of three...
9 KB (803 words) - 03:27, 15 August 2024
caused by a defective estrogen receptor (ER) – specifically, the estrogen receptor alpha (ERα) – that results in an inability of estrogen to mediate its biological...
34 KB (3,802 words) - 00:18, 4 January 2024
Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is...
17 KB (1,995 words) - 21:24, 29 March 2024
nuclear receptors include members of subfamily 3, such as the androgen receptor, estrogen receptors, glucocorticoid receptor, and progesterone receptor. It...
74 KB (6,675 words) - 18:09, 20 June 2024
with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones. There are three human estrogen related receptors: ERRα...
11 KB (1,175 words) - 13:05, 3 December 2023
studied steroid hormone receptors are members of the nuclear receptor subfamily 3 (NR3) that include receptors for estrogen (group NR3A) and 3-ketosteroids...
23 KB (2,796 words) - 19:08, 19 February 2024
Membrane estrogen receptors (mERs) are a group of receptors which bind estrogen. Unlike nuclear estrogen receptors, which mediate their effects via slower...
19 KB (1,985 words) - 03:22, 24 May 2024
A selective estrogen receptor degrader or downregulator (SERD) is a type of drug which binds to the estrogen receptor (ER) and, in the process of doing...
5 KB (440 words) - 13:49, 19 May 2024
Clomifene (category Selective estrogen receptor modulators)
unknown cause or who are pregnant. Clomifene is in the selective estrogen receptor modulator (SERM) family of medication and is a nonsteroidal medication...
45 KB (4,675 words) - 22:12, 13 August 2024
of selective estrogen receptor modulators (SERMs) became evident. The first SERM, tamoxifen, was originally developed as an anti-estrogen contraceptive...
74 KB (6,757 words) - 07:32, 24 June 2024
Hormonal therapy (oncology) (redirect from Estrogen therapy (oncology))
intracellular, as in the case of steroid hormone receptors.[citation needed] Selective estrogen receptor modulators (SERMs) are an important class of hormonal...
12 KB (1,363 words) - 20:23, 16 August 2024
cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive,...
19 KB (1,832 words) - 12:55, 3 August 2024
among others. Estrogens are agonists of the estrogen receptors, the biological targets of endogenous estrogens like estradiol. They have important effects...
131 KB (14,549 words) - 19:46, 1 August 2024
Tamoxifen (category Selective estrogen receptor modulators)
sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. It is also...
87 KB (8,744 words) - 18:03, 16 August 2024
Hormone therapy (redirect from Anti-estrogen therapy)
cancer Estrogen deprivation therapy for women with estrogen receptor-positive breast cancer High-dose estrogen therapy for women with estrogen receptor-positive...
7 KB (749 words) - 20:23, 16 August 2024
Endocrine therapy is a common treatment for estrogen receptor positive breast cancer. However, resistance to this therapy can develop, leading to relapse...
27 KB (3,317 words) - 11:14, 7 January 2024
Raloxifene (category Selective estrogen receptor modulators)
a selective estrogen receptor modulator (SERM) and therefore a mixed agonist–antagonist of the estrogen receptor (ER). It has estrogenic effects in bone...
49 KB (5,045 words) - 20:01, 20 December 2023
selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer [30] Fulvestrant-3 boronic acid (ZB716) – estrogen receptor antagonist...
14 KB (1,217 words) - 08:59, 1 August 2024
Fulvestrant (category Selective estrogen receptor degraders)
is a selective estrogen receptor degrader (SERD) and was first-in-class to be approved. It works by binding to the estrogen receptor and destabilizing...
27 KB (2,341 words) - 12:12, 14 June 2024
GPER (redirect from G Protein-coupled Estrogen Receptor 1)
G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene...
35 KB (3,987 words) - 16:29, 25 July 2024
are estrogens, or agonists of the estrogen receptor, the biological target of estrogens like estradiol. Compared to estradiol, certain estrogens in CEEs...
58 KB (6,452 words) - 17:15, 3 August 2024
Estradiol (category Estrogens)
loss of bone mass due to a relative estrogen deficiency. The estrogen receptor, as well as the progesterone receptor, have been detected in the skin, including...
75 KB (7,245 words) - 18:33, 11 August 2024
production of estrogen or block the action of estrogen on receptors. In contrast to premenopausal women, in whom most of the estrogen is produced in...
21 KB (2,051 words) - 06:17, 13 January 2024
Norethisterone (category Synthetic estrogens)
agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak androgenic and estrogenic activity, mostly at high...
92 KB (9,328 words) - 04:45, 11 July 2024
found to play a direct, augmenting role as well, as it increases estrogen receptor (ER) expression in breast stromal (connective) tissue, while IGF-1...
59 KB (6,495 words) - 08:42, 1 July 2024