Exon shuffling is a molecular mechanism for the formation of new genes. It is a process through which two or more exons from different genes can be brought...
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in overall reputable secondary sources. DBASS3/5 Exitron Exon-intron database Exon shuffling Interrupted gene Outron Twintron Untranslated region (UTR)...
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Genome evolution (section Exon shuffling)
Exon shuffling is a mechanism by which new genes are created. This can occur when two or more exons from different genes are combined or when exons are...
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Protein engineering (section Exon shuffling)
Paralogous exon shuffling involves shuffling of exon from different genes from the same species. Paralogous domain shuffling involves shuffling of entire...
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presence of these exons in protein transcripts. Exon shuffling Gene duplication Letunic I, Copley RR, Bork P (Jun 2002). "Common exon duplication in animals...
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the adjacent base pairs; this phenomenon is called exon shuffling. Shuffling two unrelated exons can create a novel gene product or, more likely, an...
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them, exon shuffling may occur. Exon shuffling is the creation of novel gene products due to the new placement of two previously unrelated exons through...
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been shown to be involved in processes such as transcript fusions, exon shuffling and creating artificial antisense transcripts. It has been speculated...
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spliceosome Outron Function MicroRNA Others: Exon shuffling Intein Noncoding DNA Noncoding RNA Selfish DNA Twintron Exon-intron database "The notion of the cistron...
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that it has evolved from ancient ancestors by gene duplication and exon shuffling. Perlecan consists of a core protein of molecular weight 469 kDa to...
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modifications. Comparative genomics DbDNV (2010) De novo gene birth Exon shuffling Gene amplification in Paramecium tetraurelia Gene fusion Horizontal...
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for new genes through studies of homologues include gene duplication, exon shuffling, gene fusion and fission, etc. Studying the origins of a gene becomes...
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genes result from domain shuffling, which is accomplished via exon shuffling, gene fusion, or gene fission. Domain shuffling has been found to be at least...
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to form new combinations with new functions (exon shuffling). When new genes are assembled from shuffling pre-existing parts, domains act as modules with...
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organizations of the MHC genes were a result of later cis-duplication and exon shuffling in a process termed "the MHC Big Bang." Genes in this locus are apparently...
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animals sequenced to date, due to high rates of genetic changes like exon shuffling and domain combination. Among the three extant (living) genera, Asymmetron...
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fusion protein. Chimeric gene De novo gene birth ETV6-NTRK3 gene fusion Exon shuffling Gene duplication Horizontal gene transfer List of RNA-Seq bioinformatics...
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Split gene theory (section Short exons/long introns)
do genes exhibit the supposed exon shuffling phenomenon. Furthermore, molecular biologists questioned the exon shuffling proposal, from a purely evolutionary...
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Stemmer, Willem P. C. (2001-05-01). "Directed evolution of proteins by exon shuffling". Nature Biotechnology. 19 (5): 423–428. doi:10.1038/88084. PMID 11329010...
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CLAssification of Mobile genetic Elements) database De novo gene birth Exon shuffling Gene fusion Gene duplication Horizontal gene transfer Virulence factors...
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Q, et al. (December 2005). "Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains". Nat. Biotechnol. 23 (12): 1556–61...
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Circular RNA (section Exon scrambling)
distinct alternatively spliced isoforms. Exon scrambling, also called exon shuffling, describes an event in which exons are spliced in a "non-canonical" (atypical)...
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secreted mucin-like protein with a C-type lectin domain: A new model of exon shuffling". Genomics. 57 (2): 316–7. doi:10.1006/geno.1999.5762. PMID 10198175...
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retrotransposition. Insertion of a SINE upstream of a coding region may result in exon shuffling or changes to the regulatory region of the gene. Insertion of a SINE...
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Evolutionary rate Excision repair Exconjugant Exogenote Exogenous DNA Exon Exon shuffling Exonuclease Expected progeny difference Experimental design Expressed...
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been used for the construction of various modular proteins through exon-shuffling. It has been found in various metazoan proteins in association with...
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sequence would be captured. In this regard, Helitrons can be viewed as an exon shuffling machines. As a random sequence provides the novel termination signal...
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; Stemmer, W. P. C. (2005). "Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains". Nature Biotechnology. 23 (12):...
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better understanding of its mechanism of action. combinatorial chemistry exon shuffling - note that although introns are conceptually analogous to inteins,...
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sequence in RNA transcripts. Contrast exon. intron intrusion intron-mediated recombination See exon shuffling. invagination The infolding of a membrane...
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