Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene. The protein encoded by this gene is a member of the fibroblast growth...

association of this trait with a retro-gene coding for fibroblast growth factor 4 (FGF4). Therefore, it seems unlikely that dogs and humans are achondroplastic for...

M.; Quignon, P.; Margulies, E. H.; et al. (16 July 2009). "An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic...

cause polydactyly in the Dorking chicken breed, which is due to ectopic FGF4 expression in the AER, with ectopic SHH a secondary effect. Silkies lay a...

Lindblad-Toh, K; Andersson, L; Andersson, G (November 2007). "Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in...

and controls cell death. The AER secretes further growth factors FGF8 and FGF4 which maintain the FGF10 signal and induce proliferation in the mesoderm...

mesoendodermal identity, followed by the pharmacological upregulation of Wnt3a and Fgf4 signaling pathways as they have been demonstrated to promote posterior gut...

factor 2(FGF2) Fibroblast growth factor 3(FGF3) Fibroblast growth factor 4(FGF4) Fibroblast growth factor 5(FGF5) Fibroblast growth factor 6(FGF6) Fibroblast...

Fgf1 Viable Unclear Fgf3 Viable Inner ear, skeletal (tail) differentiation Fgf4 Lethal Inner cell mass proliferation Fgf8 Lethal Gastrulation defect, CNS...

apical ectodermal ridge (AER). The AER reciprocatively secretes FGF8 and FGF4 which maintains the FGF10 signal and induces proliferation in the mesoderm...

characteristics. It has been shown that one transcriptional target of Oct4 is the Fgf4 gene. This gene normally encodes a ligand secreted by the ICM, which induces...

the function of Fgf4 in paraxial mesoderm specification (14). Inhibition of FGFR results in a significant reduction of both Xbra and Fgf4 expression. Although...

surrounding coat. The ridge is caused by a duplication of several genes (FGF3, FGF4, FGF 19, ORAOV1 and sometimes SNP), and ridge is dominant to non-ridged....

expressed in undifferentiated ESCs, including Oct-3/4, Sox2, Nanog, GDF3, REX1, FGF4, ESG1, DPPA2, DPPA4, and hTERT. Telomerase activity: Telomerases are necessary...

create the AER, which expresses FGF8. The AER is known to express FGF2, FGF4, FGF8, and FGF9, while the limb bud mesenchyme expresses FGF2 and FGF10....

histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4". Cell Res. 20 (2): 154–65. doi:10.1038/cr.2010.5. PMID 20084082. PDBe-KB...

HGNC:3665 P05230 5632 FGF2 HGNC:3676 P09038 5633 FGF3 HGNC:3681 P11487 5634 FGF4 HGNC:3682 P08620 5635 FGF5 HGNC:3683 P12034 5636 FGF6 HGNC:3684 P10767 5637...

years: odontoma-dysphagia syndrome is most likely caused by a microduplication of chromosome 11q13.3, including the FGF3 and FGF4 genes. Clin Oral Investig...

into pluripotency. Oct4 works in conjecture with Sox2 for the expression of FGF4 which could aid in differentiation. Sox2 is a gene used in maintaining pluripotency...

McMahon AP, Zeller R (1999). "Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds". Nature. 401 (6753): 598–602. Bibcode:1999Natur...

which induces Shh expression in the posterior mesoderm. Shh then stimulates FGF4 to be expressed in the posterior part of the AER. After these events, there...

family influenced by transposable elements is the fgf family.  Fgf3 and Fgf4 are lost in weedy and leafy seadragons, which is shocking considering their...

occur, as well as delays in subsequent expressions of other genes (Shh or FGF4). FGF8 is responsible for cell proliferation and survival, as well. Loss...

Katoh M, Katoh M (2003). "Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human". Int. J. Mol. Med. 12 (1): 45–50. doi:10.3892/ijmm...

early dental epithelium in mice such as Bmp4, Bmp7, Dlx2, Dlx5, Fgf1, Fgf2, Fgf4, Fgf8, Lef1, Gli2, and Gli3 are also potential candidates. Based on existing...

permanent trophoblast stem cell lineages using fibroblast growth factor 4 (FGF4) in contact with mouse blastocysts or early postimplantation trophoblasts...

During limb bud development, down-regulation of Tbx2 fails to inhibit Shh/FGF4 signaling; therefore, resulting in increased limb bud size and duplication...

dividing, and appears to be under the regulation of retinoic acid, FGF2, FGF4, and BMP-2 – known to regulate limb patterning. EphA4 defective mice do not...