Farnesyltransferase (EC 2.5.1.58) is one of the three enzymes in the prenyltransferase group. Farnesyltransferase (FTase) adds a 15-carbon isoprenoid...
8 KB (840 words) - 03:59, 5 October 2023
The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of...
12 KB (1,079 words) - 17:42, 26 May 2021
methylation. Carboxyl methylation only occurs on prenylated proteins. Farnesyltransferase and geranylgeranyltransferase I are very similar proteins. They consist...
15 KB (1,810 words) - 16:46, 26 June 2024
1126/science.1153018. PMC 2747771. PMID 18276850. Farnesyl-Diphosphate+Farnesyltransferase at the U.S. National Library of Medicine Medical Subject Headings...
26 KB (3,078 words) - 23:35, 10 March 2024
triggers three sequential enzymatic modifications. First, protein farnesyltransferase catalyzes the addition of a farnesyl moiety to the cysteine. Second...
59 KB (6,094 words) - 15:22, 31 May 2024
Presqualene diphosphate synthase (redirect from (2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase (presqualene diphosphate forming))
systematic name (2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase (presqualene diphosphate forming). This enzyme catalyses the following...
1 KB (118 words) - 15:31, 26 August 2023
Farnesyl-diphosphate farnesyltransferase 1 is a protein that in humans is encoded by the FDFT1 gene. This gene encodes a membrane-associated enzyme located...
1 KB (190 words) - 21:31, 3 May 2024
Tipifarnib (category Farnesyltransferase inhibitors)
name Zarnestra) is a farnesyltransferase inhibitor. Farnesyltransferase inhibitors block the activity of the farnesyltransferase enzyme by inhibiting...
9 KB (673 words) - 20:57, 1 December 2023
Protein farnesyltransferase subunit beta is an enzyme that in humans is encoded by the FNTB gene. GRCm38: Ensembl release 89: ENSMUSG00000033373 – Ensembl...
7 KB (868 words) - 15:57, 15 January 2024
manipulate the regulation of the above-mentioned localization of Ras. Farnesyltransferase inhibitors have been developed to stop the farnesylation of Ras and...
34 KB (4,040 words) - 16:04, 10 July 2024
affinity modulator Sickle cell disease 2019 Lonafarnib (Zokinvy) Farnesyltransferase inhibitor Hutchinson-Gilford progeria syndrome 2020 2022 Dupilumab...
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Australia Fair Trials International, a British human rights organization Farnesyltransferase inhibitor, a class of cancer drugs Federation of Thai Industries...
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Lonafarnib (category Farnesyltransferase inhibitors)
midazolam and certain cholesterol-lowering medications. Lonafarnib, a farnesyltransferase inhibitor, is an oral medication that helps prevent the buildup of...
15 KB (1,042 words) - 05:37, 3 February 2024
an Ala, Met, Ser or Gln the protein will be farnesylated via the farnesyltransferase enzyme and if the X is a Leu then the protein will be geranylgeranylated...
20 KB (2,232 words) - 07:44, 22 June 2024
are used infrequently in English. Sebti; Hamilton, eds. (2001). Farnesyltransferase inhibitors in cancer therapy. p. 126. ISBN 9780896036291. Retrieved...
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as drug R115777) inhibits the activation of RAS. This drug is a Farnesyltransferase inhibitor which inhibits the Ras kinase in a post translational modification...
30 KB (3,257 words) - 16:02, 28 February 2024
onto the C-terminal consensus sequence CAAL (somewhat similar to farnesyltransferase reactions), where C=cysteine, A=any aliphatic amino acid, and L=leucine...
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treatment he devised for children affected by Progeria. He discussed how farnesyltransferase inhibitors (FTIs) affects H-Ras. After his presentation, members...
12 KB (1,406 words) - 23:36, 23 April 2023
Ghassemian M, Kwak CM, McCourt P, & Schroeder JI (1998) Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss...
25 KB (3,442 words) - 11:11, 5 April 2024
4,4'-Diapophytoene synthase (redirect from Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (4,4'-diapophytoene forming))
enzyme with systematic name farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (4,4'-diapophytoene forming). This enzyme catalyses the following...
3 KB (270 words) - 12:43, 26 August 2023
Protoheme IX farnesyltransferase, mitochondrial is an enzyme that in humans is encoded by the COX10 gene. Cytochrome c oxidase (COX), the terminal component...
12 KB (1,374 words) - 10:30, 14 August 2023
prompted intense pharmaceutical industry pursuit of inhibitors of the farnesyltransferase enzyme that catalyzes this lipid modification on RAS and other proteins...
9 KB (745 words) - 10:16, 7 April 2024
being translated, a farnesol is added to prelamin A using protein farnesyltransferase; this farnesylation is important in targeting lamin to the nuclear...
74 KB (8,726 words) - 06:14, 3 June 2024
COMT Thymidylate synthase 2.4 PARP 2.5 Dihydropteroate synthetase Farnesyltransferase 2.6 GABA transaminase 2.7 Nucleotidyltransferase Integrase Reverse...
36 KB (2,981 words) - 17:57, 23 June 2024
random screening of natural extracts. Clavaric acid is a reversible farnesyltransferase inhibitor with an IC50 of 1.3 μM. Lingham RB, Silverman KC, Jayasuriya...
2 KB (130 words) - 22:11, 4 November 2023
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha is an enzyme that in humans is encoded by the FNTA gene. Prenyltransferases...
8 KB (1,005 words) - 11:27, 13 January 2024
protein F-box protein 16 FDFT1 encoding protein Farnesyl-diphosphate farnesyltransferase 1 FGFR1: fibroblast growth factor receptor 1 (fms-related tyrosine...
29 KB (1,896 words) - 23:26, 28 March 2024
attack on the geranylgeranyl diphosphate, displacing the diphosphate. Farnesyltransferase Prenylation Rab geranylgeranyltransferase – Geranylgeranyltransferase...
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Reiss Y, Casey PJ, Brown MS, Goldstein JL (May 1991). "Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit". Cell...
32 KB (3,286 words) - 16:48, 25 June 2024
basis for the development of anticancer drugs due to their strong farnesyltransferase inhibitory effects. A series of alkyl- and alkenyl-itaconates, known...
35 KB (3,136 words) - 21:41, 23 June 2024