mammals, including humans, GSK-3 exists in two isozymes encoded by two homologous genes GSK-3α (GSK3A) and GSK-3β (GSK3B). GSK-3 has been the subject of...

Numajiri M, Murayama O, Yoshihara E, et al. (2013). "Haplotype analysis of GSK-3β gene polymorphisms in bipolar disorder lithium responders and nonresponders"...

to alter glycogen synthase kinase-3 beta (GSK-3β) activity. Specifically, Akt and ERK phosphorylate GSK-3β, inactivating the enzyme, and inhibiting the...

GSK-3β is a downstream target of monoamine systems. As such, it is directly implicated in cognition and mood regulation. During mania, GSK-3β is activated...

does so by activating Akt while inactivating glycogen synthase kinase-3β (GSK-3β), an inhibitor of the Akt pathway. Emodin specifically causes phosphorylation...

NK1 receptor antagonist ARA-014418 (AR-A014418; GSK-3β Inhibitor VIII) – glycogen synthase kinase GSK-3β inhibitor [205] Armodafinil (CEP-10953; Nuvigil;...

kinase-3 (GSK)-3β inhibits transcription by nuclear ER by inhibiting phosphorylation of serine 118 of nuclear ERα. Phosphorylation of GSK-3β removes its...

adenocarcinoma), believed to be caused by mediation of glycogen synthase kinase 3 β (GSK-3β). In the same study administration of proadifen was demonstrated to produce...

Christopher P.; Woodgett, James R.; Abraham, David J.; Leask, Andrew (2008). "GSK-3β in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1–dependent...

agonist ameliorates MK801-induced dysfunction of NMDA receptors via the Akt/GSK-3β pathway in adult rat prefrontal cortex". Neuropsychopharmacology. 36 (6):...

kinase 1 (CK1), which carries out an initial phosphorylation of β-catenin, GSK-3β is able to phosphorylate β-catenin a second time. This targets β-catenin...

function of endothelial progenitor cells under oxidative stress via PI3K/Akt/GSK-3β and ERK1/2 signaling pathways. Bosn J of Basic Med Sci [Internet]. 2020Jan...

Perikaryal Accumulation of Phosphorylated Neurofilaments: Roles of JNK and GSK-3β". Brain Research. 1181: 74–82. doi:10.1016/j.brainres.2007.04.019. PMID 17961518...

is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor. Tideglusib has been evaluated in clinical trials for: Alzheimer's...

translocation, contributing to neuronal death. Glycogen synthase kinase 3β (GSK-3β) is responsible for tau phosphorylation and controls several cellular...

inhibits glycogen synthase kinase (GSK 3β), an enzyme that phosphorylates and stabilizes Rev-erbα. Lithium binding to GSK 3β then destabilizes and alters the...

Dichloropane ((−)-2β-Carbomethoxy-3β-(3,4-dichlorophenyl)tropane, RTI-111, O-401) is a stimulant of the phenyltropane class that acts as a...

in Alzheimer's disease. Studies suggest that glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent protein kinase 5 (Cdk5) are highly expressed in...

severe combined immune-deficient mice. GSK-3β mRNA is a direct target of miR-26a, miR-26a-mediated reduction of GSK-3β results in activation of β-catenin...

(2011). "Elucidating Substrate and Inhibitor Binding Sites on the Surface of GSK-3β and the Refinement of a Competitive Inhibitor". Journal of Molecular Biology...

to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride...

Aghajanian: Neurobiology of Rapid Acting Antidepressants: Role of BDNF and GSK-3β. Neuropsychopharmacology. Ronald S. Duman and George K. Aghajanian: Synaptic...

(2010). "ZM336372 Induces Apoptosis Associated With Phosphorylation of GSK-3β in Pancreatic Adenocarcinoma Cell Lines". Cancer Chemother Pharmacol. 161...

Hoorn FA (2012). "Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β". PLOS ONE. 7 (11): e48773. Bibcode:2012PLoSO...748773O. doi:10.1371/journal...

calcium level drops, the exporting kinases in a nucleus such as PKA, CK1 or GSK-3β rephosphorylate NFAT. This causes that NFAT reverts into its inactive state...

epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical...

increase in the Bax and cleaved-PARP apoptotic proteins, while inhibiting the GSK-3β/NF-κB signaling pathway. With regards to the induction of apoptosis, cinobufagin...

androgen receptor (AR), and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD), CYP11B1 (steroid 11β-hydroxylase), CYP21A2 (Steroid...

Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid...

nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage". Stroke. 43 (3):...