• Glycosylphosphatidylinositol (pronunciation) or glycophosphatidylinositol (GPI) is a phosphoglyceride that can be attached to the C-terminus of a protein...
    6 KB (656 words) - 16:08, 10 July 2024
  • Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific...
    3 KB (276 words) - 14:23, 26 August 2023
  • The enzyme glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) catalyzes the reaction 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol =...
    3 KB (249 words) - 14:23, 26 August 2023
  • Thumbnail for Fosmanogepix
    targets the enzyme GWT1 (Glycosylphosphatidylinositol-anchored Wall protein Transfer 1), an enzyme in the glycosylphosphatidylinositol biosynthesis pathway...
    6 KB (380 words) - 22:59, 5 August 2024
  • C-terminal modification is the addition of a phosphoglycan, glycosylphosphatidylinositol (GPI), as a membrane anchor. The GPI anchor is attached to the...
    5 KB (583 words) - 18:03, 18 April 2024
  • Thumbnail for Membrane protein
    with added fatty acid, diacylglycerol or prenyl chains, or GPI (glycosylphosphatidylinositol), which may be anchored in the lipid bilayer. Polypeptide toxins...
    18 KB (1,819 words) - 23:55, 25 April 2024
  • Thumbnail for Lipid-anchored protein
    which include prenylated proteins, fatty acylated proteins and glycosylphosphatidylinositol-linked proteins (GPI). A protein can have multiple lipid groups...
    20 KB (2,232 words) - 07:44, 22 June 2024
  • Thumbnail for PIGK
    member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found...
    7 KB (927 words) - 09:55, 11 December 2023
  • Thumbnail for Lipoprotein lipase
    luminal surface of endothelial cells in capillaries by the protein glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1) and by heparan sulfated peptidoglycans...
    33 KB (4,021 words) - 02:22, 3 July 2024
  • Thumbnail for Metabolism
    "Recent developments in the cell biology and biochemistry of glycosylphosphatidylinositol lipids (review)". Molecular Membrane Biology. 17 (1): 1–16. doi:10...
    113 KB (12,408 words) - 18:04, 20 August 2024
  • Glypiation is the addition by covalent bonding of a glycosylphosphatidylinositol (GPI) anchor and is a common post-translational modification that localizes...
    6 KB (746 words) - 22:15, 8 June 2024
  • Thumbnail for CD14
    CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol (GPI) tail (mCD14), the other a soluble form (sCD14). Soluble...
    7 KB (845 words) - 09:05, 27 March 2024
  • Thumbnail for PGAP1
    gene. The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation...
    1 KB (201 words) - 07:54, 17 May 2023
  • Thumbnail for PIGH
    endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found...
    5 KB (585 words) - 01:48, 4 March 2023
  • Thumbnail for Glycolipid
    PMC 2386904. PMID 18334715. Paulick MG, Bertozzi CR (July 2008). "The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins"...
    13 KB (1,589 words) - 14:46, 23 January 2024
  • Thumbnail for GPLD1
    to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood...
    9 KB (984 words) - 23:14, 3 March 2023
  • Thumbnail for SAG1 protein domain
    biology, the SAG1 protein domain is an example of a group of glycosylphosphatidylinositol (GPI)-linked proteins named SRSs (SAG1 related sequence). SAG1...
    4 KB (359 words) - 03:49, 29 November 2023
  • Intectin is a Ly-6 family protein which is anchored to glycosylphosphatidylinositol on intestinal epithelial cells. Intectin has been shown to maintain...
    2 KB (160 words) - 05:13, 12 January 2024
  • Thumbnail for Major prion protein
    PrPC attaches to the outer surface of the cell membrane by a glycosylphosphatidylinositol anchor at its C-terminal Ser231. Prion protein contains five...
    45 KB (5,140 words) - 04:58, 3 August 2024
  • Thumbnail for PIGC
    endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid...
    5 KB (681 words) - 18:44, 7 November 2023
  • Thumbnail for Post-translational modification
    geranylgeraniol) farnesylation geranylgeranylation glypiation, glycosylphosphatidylinositol (GPI) anchor formation via an amide bond to C-terminal tail lipoylation...
    33 KB (3,189 words) - 03:12, 28 March 2024
  • Thumbnail for Human herpesvirus 6
    membranous microdomains enriched by cholesterol, sphingolipids, and glycosylphosphatidylinositol-anchored proteins. Early researchers suspected that HHV-6 virions...
    78 KB (8,112 words) - 16:36, 5 July 2024
  • Thumbnail for Receptor tyrosine kinase
    order to activate RET, first GFLs must form a complex with a glycosylphosphatidylinositol (GPI)-anchored co-receptor. The co-receptors themselves are classified...
    28 KB (3,078 words) - 07:46, 3 June 2024
  • Thumbnail for PIGS (gene)
    encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves...
    4 KB (547 words) - 21:05, 13 October 2022
  • Thumbnail for Hyperphosphatasia with mental retardation syndrome
    PIGV is a member of the molecular pathway that synthesizes the glycosylphosphatidylinositol anchor. The loss in PIGV activity results in a reduced anchoring...
    7 KB (593 words) - 16:51, 3 December 2023
  • Thumbnail for Adp-ribosyltransferase 5
    residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme...
    955 bytes (159 words) - 11:43, 30 September 2023
  • Thumbnail for PIGF
    the PIGF gene. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which...
    5 KB (610 words) - 06:46, 7 January 2024
  • Thumbnail for PIGA
    Orlean P; Takeda J; Kinoshita T (Feb 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C...
    9 KB (1,106 words) - 20:03, 27 October 2023
  • Thumbnail for GPIHBP1
    Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPI-HBP1) also known as high density lipoprotein-binding protein 1 is...
    8 KB (784 words) - 01:47, 11 December 2023
  • Thumbnail for PIGQ
    by the PIGQ gene. This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found...
    5 KB (663 words) - 15:24, 28 October 2022