humans is encoded by the HMGB1 gene. HMG-1 belongs to the high mobility group and contains a HMG-box domain. Like the histones, HMGB1 is among the most important...

Protein DAMPs include intracellular proteins, such as heat-shock proteins or HMGB1, and materials derived from the extracellular matrix that are generated...

reduction or inhibition of the high mobility group box1 protein (HMGB1) in neuron mitochondria. HMGB1 is a crucial nuclear protein that regulates DNA architectural...

contains an AT-hook domain HMGA1 HMGA2 HMGB – contains a HMG-box domain HMGB1 HMGB2 HMGB3 HMGB4 HMGN – contains a nucleosomal binding domain HMGN1 HMGN2...

negative regulation of the HMGB1-DNA interaction that was suspected to be largely controlled by the acidic tail of HMGB1. They found that regardless...

molecular patterns (DAMPs), including high mobility group box protein 1 (HMGB1), S100 proteins, or histones. These compounds are released during tissue...

published 1999-02-23  Hwang JH, Chu H, Ahn Y, Kim J, Kim DY (April 2019). "HMGB1 promotes hair growth via the modulation of prostaglandin metabolism". Scientific...

cytochrome c release (Western blotting). Supernatant screening for caspases, HMGB1, and cytokeratin 18 release can identify primary from secondary necrotic...

identified, such as phosphatidylserine (PtdSer), High Mobility Group Protein 1 (HMGB1) and Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1)...

Kuznik, BI; Tarnovskaia, SI; Lin'kova, NS (2014). "Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data". Adv Gerontol...

at least one other agonistic ligand: high mobility group protein B1 (HMGB1). HMGB1 is an intracellular DNA-binding protein important in chromatin remodeling...

diagnosis of TEN. Serum granulysin and serum high-mobility group protein B1 (HMGB1) are among a few of the markers being investigated which have shown promise...

Elevated expression of HMGB1 was found in the sera of people and mice with systemic lupus erythematosus, high mobility group box 1 (HMGB1) is a nuclear protein...

initiation by MMR genes) in humans include DNA polymerase delta, PCNA, RPA, HMGB1, RFC and DNA ligase I, plus histone and chromatin modifying factors. In...

amphoterin-HMGB1, a multifunctional protein, directly and may cause deleterious effects in cellular functions by interference with HMGB1. Horse and human...

system mediate the inflammatory response. These cytokines include TNF, HMGB1, and IL-1. The inflammatory response is characterized by the following symptoms:...

Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication: An active ingredient Glycyrrhizin...

nuclear protein HMGB1 and RAGE protein, which together act as a ligand for TLR9. HMGB1 is released from lysed or damaged cells. HMGB1-DNA complex then...

EIF2AK2, ELL, EP300, ERCC6, GNL3, GPS2, GSK3B, HSP90AA1, HIF1A, HIPK1, HIPK2, HMGB1, HSPA9, Huntingtin, ING1, ING4, ING5, IκBα, KPNB1, LMO3, Mdm2, MDM4, MED1...

tendinopathy development. Additionally, his work emphasized the role of HMGB1 as a pivotal molecule in mechanically induced tendinopathy and proposed...

alphav-beta6 complex alphav-beta3 integrin-PKCalpha complex alphav-beta3 integrin-HMGB1 complex Biological process regulation of phagocytosis apoptotic cell clearance...

is the first enzymatic step in pyrimidine synthesis. Regulated by MITF) HMGB1 High mobility group box binds DNA ILF2 Homo sapiens interleukin enhancer...

double-strand break and PARP-1 was involved in replacing histone H1 by HMGB1/HMGA2, which can promote transcription. Topo IIβ and PARP-1 increased at...

including fibrinogen (involved in blood clotting), heat shock proteins (HSPs), HMGB1, extracellular matrix components and self DNA (it is normally degraded by...

HGNC:5002 Q9P0W2 7118 HMGA1 HGNC:5010 P17096 7119 HMGA2 HGNC:5009 P52926 7120 HMGB1 HGNC:4983 P09429 7121 HMGB2 HGNC:5000 P26583 7122 HMGB3 HGNC:5004 O15347...

macrophages that increase with age in many tissues. ADP-riboyslation of the HMGB1 high-mobility group protein by PARP1 inhibits removal of apoptotic cells...

group box 1 (HMGB1), a protein previously known as a DNA-binding transcription factor, is an inflammatory mediator. The discovery of HMGB1 as a damaged...

form of lytic cell death that releases inflammatory molecules such as ATP, HMGB1 and IL-1α from the cytosol. Inflammatory cytokines such as IL-1β and IL-18...

1065982. PMID 11743158. S2CID 27442721. Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino...

response. Other important DAMPs, characteristic for ICD are secreted HMGB1 and ATP. HMGB1 is considered to be a marker of late ICD and its release to the extracellular...