Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate...

clots to form. Moreover, most malignant tumors overexpress and secrete heparanase, an enzyme that degrade heparan sulfate and endogenous heparin, and thus...

Heparanase (EC 3.2.1.166, Hpa1 heparanase, Hpa1, heparanase 1, heparanase-1, C1A heparanase, HPSE) is an enzyme with systematic name heparan sulfate...

and nuclear translocation of mitogen-activated protein (MAP) kinases. Heparanase cleaves heparin sulfate chains of HSPGs, which have an extensive network...

antiadhesive, antimetastatic Phosphomannopentanose sulfate Potent inhibitor of heparanase activity Antimetastatic, antiangiogenic, anti-inflammatory Selectively...

syndecan-1 only after heparanase modification. Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off...

hydrolase family 79 includes endo-beta-N-glucuronidase EC 3.2.1.31 and heparanase (CAZY GH_79). Heparan sulphate proteoglycans (HSPGs) play a key role in...

due to treatment with antineoplastic medications; and (3) secretion of heparanase from malignant tumors that results in degradation of endogenous heparin...

Diagram showing a pancreatic islet and four stages of T1D disease driven by heparanase and loss of intra-islet glycosaminoglycan heparan sulfate (HS)...

Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene. It may be associated with urofacial syndrome. GRCh38: Ensembl release 89: ENSG00000172987...

2009). "Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma". Cancer...

Matzner Y, Cohen IR, Fuks Z, Vlodavsky I (August 1987). "Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant...

cells lacking heparanase after siRNA depletion. Binding was restored by spiking in exogenous heparanase or heparitinase. Thus, heparanase regulates lacritin...

a wound. Because heparan sulfate is broken down in chronic wounds by heparanase, the analogues only bind sites where natural heparan sulfate is absent...

Trachyspic acid is a fungal isolate that can inhibit heparanase. Shiozawa H, Takahashi M, Takatsu T, Kinoshita T, Tanzawa K, Hosoya T, Furuya K, Takahashi...

of tissue injury, the soluble syndecan-1 ectodomains are cleaved by heparanases, producing heparin-like fragments that activate bFGF [13]. Whereas most...

resistance. Masola V, Maran C, Tassone E, Zin A, Rosolen A, Onisto M (2009). "Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for...

Harvard Political Review Hawaii Public Radio Heartland Public Radio HPR1, Heparanase High-power rocketry Highly Protected Risk in insurance; see FM Global...

6-β-galactosidase EC 3.2.1.165: exo-1,4-β-D-glucosaminidase EC 3.2.1.166: heparanase EC 3.2.1.167: baicalin-β-D-glucuronidase EC 3.2.1.168: hesperidin...

viral surfing in herpesviruses. His laboratory was first to implicate heparanase in HSV-1 release and syndecans in HSV-1 entry and cell-to-cell fusion...

expressed in both the central nervous system as well as the bladder. Heparanase 2 is protein coded by exons 8 and 9 on the HPSE2 gene. This protein is...

identical cells. Heparan sulfate analogues cannot be degraded by all known heparanases and glycanases and bind to the free heparin sulfate binding spots on...

basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases". The Journal of Biological Chemistry. 271 (17): 10079–10086. doi:10...

the protein and demonstrating that digestion of the peptide with either heparanase or chondroitinase did not lead to complete loss of the peptide's activity...

inflammation, so also in wound areas, heparan sulfates are degraded, mainly by heparanases giving free access to protease to degrade the ECM and a subsequent loss...

human topoisomerase I inhibitor Trachyspic acid Talaromyces trachyspermus heparanase inhibitor Trichodimerol Trichoderma bio-active pentacycle Ustusolates...

HPSE may refer to: Heparanase, an enzyme Blood group B branched chain alpha-1,3-galactosidase, an enzyme This disambiguation page lists articles associated...

Andrzej M; Davies, Gideon J (2015). "Structural characterization of human heparanase reveals insights into substrate recognition". Nature Structural & Molecular...