Holton Taxol total synthesis, published by Robert A. Holton and his group at Florida State University in 1994, was the first total synthesis of Taxol...
16 KB (1,478 words) - 18:34, 27 September 2023
The Nicolaou Taxol total synthesis, published by K. C. Nicolaou and his group in 1994 concerns the total synthesis of taxol. Taxol is an important drug...
18 KB (1,520 words) - 17:15, 19 January 2024
after the first two efforts described in the Holton Taxol total synthesis and the Nicolaou Taxol total synthesis. Combined they provide a good insight in...
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published in 1997. This synthesis has much in common with the Holton Taxol total synthesis in that it is a linear synthesis starting from a naturally...
9 KB (1,098 words) - 07:53, 11 June 2024
successful taxol total synthesis. The total synthesis of Taxol is considered a hallmark in organic synthesis. This version is a linear synthesis with ring...
11 KB (1,294 words) - 19:02, 27 November 2023
Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). This diterpenoid is an...
16 KB (1,961 words) - 04:43, 8 August 2024
Kuwajima Taxol total synthesis by the group of Isao Kuwajima of the Tokyo Institute of Technology is one of several efforts in taxol total synthesis published...
11 KB (1,349 words) - 21:47, 16 July 2024
Holton (born 1944) is an American academic chemist who is known for his work regarding the chemical synthesis for Taxol (known as the Holton Taxol total...
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Paclitaxel (redirect from Taxol)
citations appearing at Holton and Nicolaou taxol total synthesis articles. Flam F (February 1994). "Race to synthesize taxol ends in a tie". Science...
60 KB (6,445 words) - 15:35, 26 September 2024
Holton's, Nicolaou's, and Danishefsky's total syntheses of the anti-cancer drug paclitaxel (trade name Taxol). Before beginning any organic synthesis...
26 KB (2,550 words) - 22:06, 25 September 2024
Danishefsky Taxol total synthesis was the third synthesis of taxol, a highly topical natural product. Together with the Holton Taxol total synthesis and the...
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2-hydroxy-3-keto-ester (2).[1] This procedure was employed in the Holton Taxol total synthesis.[2] The methylene bridge in the reactant with adjacent carbonyl...
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Oxaziridine (section Synthesis)
products, such as taxol which is marketed as a chemotherapy agent. Both the Holton Taxol total synthesis and the Wender Taxol total synthesis feature asymmetric...
26 KB (2,506 words) - 01:08, 14 September 2024
example is an epoxy alcohol fragmentation reaction as part of the Holton Taxol total synthesis. 3-aza-Grob fragmentation is variation which takes place when...
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ovarian cancer treatment. Holton and his organic chemistry team developed a cheaper semisynthetic version (Holton Taxol total synthesis).[citation needed] In...
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Teruaki Mukaiyama (section Taxol synthesis)
were working on the total synthesis of the chemotherapy medicine paclitaxel (Taxol), culminating with the groups of Robert A. Holton and K. C. Nicolaou...
18 KB (2,170 words) - 02:55, 14 September 2024
K. C. Nicolaou (section Total syntheses accomplished)
vancomycin. His group's route to Taxol, completed in 1994 at roughly the same time as a synthesis by the group of Robert A. Holton, attracted national news media...
10 KB (811 words) - 09:08, 13 September 2024
2000, 41, 4281. doi:10.1016/S0040-4039(00)00626-2 Holton, R. A. et al. "First total synthesis of taxol. 2. Completion of the C and D rings." J. Am. Chem...
10 KB (1,269 words) - 22:55, 13 August 2024
Mitsuru; Smith, Chase C.; Kim, Soekchan (February 1, 1994). "First total synthesis of taxol. 1. Functionalization of the B ring". Journal of the American Chemical...
153 KB (13,347 words) - 22:19, 19 September 2024
N-Carbomethoxysulfamate Esters". J. Org. Chem. 38 26-. Holton, R.A.; et al. (1994). "First Total Synthesis of Taxol. 2. Completion of the C and D Rings". J. Am....
17 KB (2,002 words) - 06:27, 8 February 2023
field of nanotechnology. In 1994, Robert A. Holton and his group achieved the first total synthesis of Taxol. In 1995, Eric Cornell and Carl Wieman produced...
72 KB (9,744 words) - 15:21, 5 July 2024
C. Nicolaou with his group and Robert A. Holton and his group, achieved the first total synthesis of Taxol. In 1995, Eric Cornell and Carl Wieman produced...
156 KB (19,387 words) - 02:04, 15 September 2024
component in the field of nanotechnology. 1994 First total synthesis of Taxol by Robert A. Holton and his group. 1995 Eric Cornell and Carl Wieman produce...
72 KB (7,490 words) - 05:50, 11 September 2024
synthesis, for example in desulfonylation reactions; annulation; Danishefsky, Kuwajima, Mukaiyama and Holton Taxol total syntheses; strychnine total synthesis;...
72 KB (8,243 words) - 17:45, 23 August 2024