• Thumbnail for Homocysteine
    Homocysteine (/ˌhoʊmoʊˈsɪstiːn/) or Hcy: is a non-proteinogenic α-amino acid. It is a homologue of the amino acid cysteine, differing by an additional...
    24 KB (2,001 words) - 17:17, 20 November 2023
  • Homocysteine methylase may refer to: Homocysteine S-methyltransferase 5-methyltetrahydropteroyltriglutamate—homocysteine S-methyltransferase This set index...
    473 bytes (46 words) - 13:27, 7 February 2015
  • Thumbnail for Homocysteine thiolactone
    Homocysteine thiolactone (HTL) is an intramolecular thioester of homocysteine synthesized by methionyl-tRNA synthetase in an error-editing reaction that...
    2 KB (180 words) - 19:33, 4 June 2024
  • Thumbnail for Methionine
    regenerated by methylation or is salvaged by removing the adenine and the homocysteine, leaving the compound dihydroxypentandione to spontaneously convert into...
    30 KB (3,054 words) - 06:15, 23 June 2024
  • Thumbnail for Hyperhomocysteinemia
    characterized by an abnormally high level of total homocysteine (that is, including homocystine and homocysteine-cysteine disulfide) in the blood, conventionally...
    20 KB (2,071 words) - 15:21, 11 April 2024
  • Thumbnail for Betaine—homocysteine S-methyltransferase
    In the field of enzymology, a betaine-homocysteine S-methyltransferase also known as betaine-homocysteine methyltransferase (BHMT) is a zinc metallo-enzyme...
    6 KB (510 words) - 11:10, 22 December 2023
  • The enzyme homocysteine desulfhydrase (EC 4.4.1.2) catalyzes the chemical reaction L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate (overall...
    2 KB (146 words) - 14:28, 26 August 2023
  • S-Adenosyl-L-homocysteine (SAH) is the biosynthetic precursor to homocysteine. SAH is formed by the demethylation of S-adenosyl-L-methionine. Adenosylhomocysteinase...
    5 KB (260 words) - 17:10, 17 September 2023
  • Thumbnail for Folate
    Methyl-B12 converts homocysteine, in a reaction catalyzed by homocysteine methyltransferase, to methionine. A defect in homocysteine methyltransferase or...
    101 KB (11,048 words) - 22:41, 26 June 2024
  • Thumbnail for Methionine synthase
    of methionine from homocysteine in most individuals. In humans it is encoded by the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase)...
    30 KB (3,437 words) - 07:25, 16 May 2024
  • Thumbnail for Homocystinuria
    cystine-homocysteine, homocysteine in homocysteine-homocysteine) via disulfide bonds. Since as an equilibrium process the proportion of free homocysteine is...
    13 KB (1,366 words) - 08:56, 2 July 2024
  • adenosylmethionine:homocysteine methyltransferase, homocysteine methylase, homocysteine methyltransferase, homocysteine transmethylase, L-homocysteine S-methyltransferase...
    3 KB (231 words) - 14:28, 26 August 2023
  • Thumbnail for Adenosylhomocysteinase
    hydrolysis of S-adenosylhomocysteine to homocysteine and adenosine. S-adenosyl-L-homocysteine + H2O ⇌ L-homocysteine + adenosine AdoHcyase is a highly conserved...
    7 KB (636 words) - 21:55, 5 July 2024
  • Thumbnail for Ethionine
    IUPAC name 2-Amino-4-ethylsulfanylbutyric acid Other names S-Ethyl-L-homocysteine Identifiers CAS Number 13073-35-3 Y 3D model (JSmol) Interactive image...
    3 KB (165 words) - 21:32, 17 September 2023
  • Thumbnail for Trimethylglycine
    has authorized the health claim that betaine "contributes to normal homocysteine metabolism." Trimethylglycine is an N-methylated amino acid. It is a...
    22 KB (1,976 words) - 15:19, 11 April 2024
  • In enzymology, a 5-methyltetrahydropteroyltriglutamate—homocysteine S-methyltransferase (EC 2.1.1.14) is an enzyme that catalyzes the chemical reaction...
    5 KB (462 words) - 15:16, 26 November 2023
  • Thumbnail for Vitamin B12 deficiency
    remethylation of homocysteine in the methionine cycle, and result in raised homocysteine levels. There is much evidence linking elevated homocysteine concentrations...
    118 KB (13,134 words) - 19:21, 1 August 2024
  • Thumbnail for Methylenetetrahydrofolate reductase
    10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Natural variation in this gene is common...
    34 KB (3,737 words) - 07:12, 15 April 2024
  • Thumbnail for S-Adenosyl methionine
    1) that use SAM as a substrate produce S-adenosyl homocysteine as a product. S-Adenosyl homocysteine is a strong negative regulator of nearly all SAM-dependent...
    23 KB (2,421 words) - 11:10, 25 June 2024
  • Thumbnail for Levomefolic acid
    level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes...
    15 KB (1,173 words) - 11:42, 25 June 2024
  • Thumbnail for Cystathionine beta synthase
    first step of the transsulfuration pathway, from homocysteine to cystathionine: L-serine + L-homocysteine ⇌ {\displaystyle \rightleftharpoons } L-cystathionine...
    26 KB (3,180 words) - 12:28, 12 December 2023
  • thetin-homocysteine S-methyltransferase (EC 2.1.1.3) is an enzyme that catalyzes the chemical reaction dimethylsulfonioacetate + L-homocysteine ⇌ {\displaystyle...
    2 KB (192 words) - 16:01, 26 August 2023
  • Thumbnail for N-Formylmethionine
    2-Formylamino-4-methylsulfanyl-butyric acid; Formylmethionine; N-Formyl(methyl)homocysteine Identifiers CAS Number 4289-98-9 Y 3D model (JSmol) Interactive image...
    11 KB (1,188 words) - 10:24, 3 February 2024
  • chemical reaction S-adenosyl-L-homocysteine + H2O ⇌ {\displaystyle \rightleftharpoons } S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine Thus, the two substrates...
    2 KB (216 words) - 12:59, 26 August 2023
  • certain enzymes. Remethylation is a major step in the conversion of homocysteine to the essential amino acid methionine. The remethylation process involves...
    3 KB (369 words) - 16:05, 11 April 2024
  • Thumbnail for Transsulfuration pathway
    is a metabolic pathway involving the interconversion of cysteine and homocysteine through the intermediate cystathionine. Two transsulfurylation pathways...
    6 KB (831 words) - 23:19, 27 March 2024
  • Thumbnail for S-ribosylhomocysteine lyase
    4.4.1.21) catalyzes the reaction S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione This enzyme belongs to...
    6 KB (639 words) - 04:25, 3 December 2023
  • Thumbnail for Megaloblastic anemia
    and hematopoietic cells. Increased homocysteine and methylmalonic acid in Vitamin B12 deficiency Increased homocysteine in folate deficiency Normal levels...
    13 KB (1,255 words) - 16:47, 29 April 2024
  • Thumbnail for Hydroxocobalamin
    hydroxocobalamine at 1 mg daily to be ineffective in reducing levels of homocysteine. In a trial on adult volunteers, this dose did not lead to a significant...
    21 KB (2,021 words) - 18:44, 15 July 2024
  • Thumbnail for Myocardial infarction
    blood levels of the amino acid homocysteine is associated with premature atherosclerosis; whether elevated homocysteine in the normal range is causal is...
    130 KB (13,860 words) - 09:50, 31 July 2024