The inverse electron demand Diels–Alder reaction, or DAINV or IEDDA is an organic chemical reaction, in which two new chemical bonds and a six-membered...

substituents on the two components. In an inverse (reverse) electron-demand Diels–Alder reaction, electron-withdrawing substituents on the diene lower...

including the inverse electron-demand Diels–Alder reaction, hexadehydro Diels–Alder reaction and the related alkyne trimerisation. The reaction can also be...

referred to simply as Click reactions Thiol-ene reaction Diels-Alder reaction and inverse electron demand Diels-Alder reaction [4+1] cycloadditions between...

The 1,2,4-triazines can react with electron-rich dienophiles in an inverse electron demand Diels-Alder reaction. This forms a bicyclic intermediate which...

than the electron-poor tetrachloroethene (see reactivity scale below). This type resembles the inverse electron-demand Diels-Alder reaction, in which...

Boger, who first reported it in 1981. The reaction is a form of inverse-electron demand Diels-Alder reaction in which an enamine reacts with a 1,2,4-triazine...

(no. 5 in the Rawal synthesis). The key step was an inverse electron demand Diels–Alder reaction of cyclophane 1 by heating in N,N-diethylaniline (dinitrogen...

SnCl4, AlCl3, and MeAlCl2 can catalyze both normal and inverse electron demand Diels-Alder reactions. The enhancement in rate is often dramatic, and regioselectivity...

synthesized from 2-hydroxy-4-methoxybenzaldehyde using the inverse electron-demand Diels–Alder reaction. Vanillin 2-Hydroxy-5-methoxybenzaldehyde Isovanillin...

immonium diene in an Inverse electron-demand Diels–Alder reaction. Researchers have extended the Grieco three-component reaction to reactants or catalysts...

high temperatures and reduced pressure. First an inverse-electron-demand hetero-Diels-Alder reaction occurred to give intermediate 45. Thermodynamically...

electronic demand for the Diels–Alder reaction calls for an electron-rich diene to react with an electron-poor olefin (or "dienophile"), while the inverse electron-demand...

symmetric, meaning the reaction between these species is allowed as well. This is referred to as the "inverse electron demand Diels–Alder." A sigmatropic rearrangement...

Other authors have used it in inverse-electron-demand Diels–Alder reactions leading to sesquiterpene dimers or in reactions forming simple derivatives....

is the reaction of a trans-cyclooctene and an s-tetrazine in an inverse-demand Diels Alder reaction followed by a retro-Diels Alder reaction to eliminate...

Zheng H, Gu Y, Xu PF (March 2022). "Organocatalytic inverse-electron-demand Diels-Alder reaction between 5-alkenyl thiazolones and β,γ-unsaturated carbonyl...

electrophiles such as Bronsted acids. Similarly, they undergo inverse demand Diels-Alder reactions. The reactivity of enol ethers is highly dependent on the...

S2CID 4086209. Dahnke, Karl R.; Paquette, Leo A. (1993). "Inverse Electron-Demand Diels-Alder Cycloaddition of a Ketene Dithioacetal. Copper Hydride-Promoted...

pyridopyridazines via a diene-transmissive Diels–Alder reaction involving inverse electron-demand hetero Diels–Alder cycloaddition of cross-conjugated azatrienes...

(2008). "The Tetrazine Ligation: Fast Bioconjugation based on Inverse-electron-demand Diels-Alder Reactivity". Journal of the American Chemical Society. 130...

Hartmann and Heuschmann: Isolation of a Zwitterion in a Diels–Alder Reaction with Inverse Electron Demand; Angewandte Chemie; september 1989; Volume 28, Issue...

setting the state for a variant of the Diels-Alder reaction termed an inverse demand Diels-Alder reaction (see curved arrows in image), which closes the...

these properties are sometimes desirable. Also, acceleration of Diels-Alder reactions by water has been observed. Supercritical water has recently been...