The Kir2.1 inward-rectifier potassium channel is a lipid-gated ion channel encoded by the KCNJ2 gene. A defect in this gene is associated with Andersen-Tawil...

denoted as Kir1 – Kir7. Each subfamily has multiple members (i.e. Kir2.1, Kir2.2, Kir2.3, etc.) that have nearly identical amino acid sequences across known...

example, mutations that disrupt an inwardly rectifying potassium channel Kir2.1 cause dominantly inherited Andersen-Tawil Syndrome (ATS). ATS patients experience...

mutations in the KCNJ2 gene which encodes the potassium channel protein Kir2.1. LQT8, also known as Timothy syndrome combines a prolonged QT interval with...

the SOX-9 transcription factor) and/or the KCNJ2 gene (which encodes the Kir2.1 inward-rectifier potassium channel) impairs the development of certain facial...

muscle cells. This specific channel (the inward rectifier potassium channel Kir2.1) carries a potassium current known as IK1 which is responsible for setting...

"Multiple PtdIns(4,5)P2 binding sites in Kir2.1 inwardly rectifying potassium channels". FEBS Letters. 490 (1–2): 49–53. doi:10.1016/S0014-5793(01)02136-6...

Electrical Diseases of the Heart. Springer London. pp. 569–581. doi:10.1007/978-1-4471-4881-4_33. ISBN 9781447148807. Schimpf R, Wolpert C, Gaita F, Giustetto...

propagates to the T-tubules where it triggers the entry of calcium ions via Cav1.1 as well as from the sarcoplasmic reticulum through the associated ryanodine...

electrically excited) of ventricular cells is around −90 millivolts (mV; 1 mV = 0.001 V), i.e. the inside of the membrane is more negative than the outside...

III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224". Naunyn-Schmiedeberg's Archives...

Hill-Eubanks DC, Nelson MT, Kinnamon SC, Liman ER (2016). "The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction"...

and membrane trafficking signal from a potassium channel (Kir2.1). The addition of Kir2.1 signal significantly improved the membrane localization of...

GRIK2 GRIK5 GRIN2A GRIN2B GRIN2C HER2/neu HGS KCNA2 KCNA4 KCNA5 KCNJ12 Kir2.1 LGI1 LRP1 LRP2 NLGN1 NOS1 PTK2B SEMA4C and SHANK2. Postsynaptic density...

observed in TREK-1 channels, which transition between lipid rafts and PIP2 domains, where they interact with an activating lipid. Similarly, Kir2.1 channels experience...

The Kir2.6 also known as inward rectifier potassium channel 18 is a protein that in humans is encoded by the KCNJ18 gene. Kir2.6 is an inward-rectifier...

KCNS3 KCNT1 KCNT2 KCNV1 KCNV2 Kenneth Stewart Cole Kim Sung-Hou Kir2.1 Kir2.6 Kir6.2 Kv1.1 KvLQT1 KvLQT2 KvLQT3 L-type calcium channel Lamellar structure...

2018). "Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model". Journal of Biological Chemistry. 293...

"Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia". Glia. 65 (1): 106–121. doi:10.1002/glia...

homotetrameric GIRK2 channel. AsKC11 has no effect on Kir2.1 or the voltage-gated potassium channels, Kv1.1-1.4 channels, and showed a small inhibition of Kv1...

rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2→p11.1". Cytogenetics and Cell Genetics. 79 (1–2): 85–7. doi:10.1159/000134688. PMID 9533018...

Picones, A; Keung, E; Timpe, LC (2001). "Unitary conductance variation in Kir2.1 and in cardiac inward rectifier potassium channels". Biophys J. 81 (4):...

C, Serdaroglu P, Subramony S, Wolfe G, Fu Y-H, Ptáček LJ. Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen’s...

inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or Kir2.3, is a human gene. Several different potassium channels are known to be...

Interleukin 16 has been shown to interact with: GRIN2A, GRIN2D, KCNJ10, KCNJ15, Kir2.1, PPP1R12A, and PPP1R12B. GRCh38: Ensembl release 89: ENSG00000172349 – Ensembl...

humans is encoded by the TRAK2 gene. TRAK2 has been shown to interact with Kir2.1 and GABRB2. GRCh38: Ensembl release 89: ENSG00000115993 – Ensembl, May 2017...

kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1". J. Biol. Chem. 276 (23): 20499–505. doi:10.1074/jbc.M101425200. PMID 11287423...

inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as Kir2.4, is a human gene. Potassium channels are present in most mammalian cells...

Wischmeyer E, et al. (2001). "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. Bibcode:2001FEBSL.491...

"Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2". Nature. 477 (7365): 495–8. Bibcode:2011Natur.477..495H. doi:10.1038/nature10370...