The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis...

calmodulin-dependent kinase II. LDL-receptor-related protein-associated protein has been shown to interact with LRP2. Lipid metabolizing proteins may elevate susceptibility...

of proteins. It is not related to C-peptide (insulin) or protein C (blood coagulation). C-reactive protein was the first pattern recognition receptor (PRR)...

Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded...

encodes the LDL receptor protein, which normally removes LDL from circulation, or the APOB gene that encodes apolipoprotein B (ApoB), the part of LDL particles...

ability to bind and remove modified low density lipoproteins (LDL). Today scavenger receptors are known to be involved in a wide range of processes, such...

synthesizes the necessary LDL receptors as well as PCSK9, a proprotein convertase that marks the LDL receptor for degradation. LDL receptors are inserted into...

lipoprotein (LDL) and removed by the liver via endocytosis of the LDL receptor. Recent evidence indicates that the members of the LDL receptor gene family...

following proteins in the plasma membrane/cytosol of cells: CUBAM, DAB2, DLG4, GIPC1, ITGB1BP1, LDL-receptor-related protein associated protein, LDLRAP1...

density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster...

oxidized-LDL induced the expression of BNP and CCL2 genes, while native LDL (N-LDL) had no effect. Treatment with melatonin in old mice with age related liver...

recognition receptor. RAGE also has at least one other agonistic ligand: high mobility group protein B1 (HMGB1). HMGB1 is an intracellular DNA-binding protein important...

within extracellular fluid. The LDL receptor (LDLR), on liver and other cell membranes, binds and initiates ingestion of LDL-particles from extracellular...

of the Lipoprotein receptor-related protein family and may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani Lenz syndactylism...

be involved in cholesterol homeostasis. The sigma-2 receptor is a four-pass transmembrane protein located in the endoplasmic reticulum. It has been found...

cells. Binding of LDL to its target tissue occurs through an interaction between the LDL receptor and apolipoprotein B-100 on the LDL particle. Absorption...

ligand/bridging factor for receptor-mediated lipoprotein uptake. Through catalysis, VLDL is converted to IDL and then to LDL. Severe mutations that cause...

to LDL cholesterol. This may be sporadic (due to dietary factors), polygenic, or truly familial as a result of a mutation either in the LDL receptor gene...

C-terminal LDL receptor binding region. In fact, ApoB48 is so-called because it constitutes 48% of the sequence for ApoB100. ApoB 48 is a unique protein to chylomicrons...

proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning...

translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded...

The chaperone protein acts as auto antigen in atherosclerosis. Increased oxidative stress causes the formation of high-density oxidized LDL, the first event...

cholesterol once the LDL particle is engulfed into the cell via receptor mediated endocytosis. NPC2 works cooperatively with the NPC1 protein to facilitate the...

Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene. The WNT gene family consists of structurally related genes that encode secreted...

and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14). PTGFR...

(LDL) is taken into the cell by binding to the LDL receptor at the cell surface. Upon reaching early endosomes, the LDL dissociates from the receptor,...

accelerate degradation of oxidized LDL cholesterol in endothelial cells, thereby lowering the risk of atherosclerosis. Oxidized LDL cholesterol is a major contributor...

apolipoprotein gene family are related. The three-dimensional structure of the LDL receptor-binding domain of apoE indicates that the protein forms an unusually elongated...

via interaction between apolipoprotein E and the LDL receptor or lipoprotein receptor-related proteins. Cholesterol is minimally soluble in water; it cannot...

fat". Other studies found that soy protein consumption could lower the concentration of low-density lipoproteins (LDL) transporting fats in the extracellular...