Leptin (from Greek λεπτός leptos, "thin" or "light" or "small"), also known as obese protein, is a protein hormone predominantly made by adipocytes (cells...

Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor, a protein that in humans is encoded by the LEPR gene. LEP-R functions as a...

Maria Leptin (born 1954) is a German developmental biologist and immunologist, and the current President of the European Research Council. She was the...

Teleost leptins are a family of peptide hormones found in fish (teleostei) that are orthologs of the mammalian hormone leptin. The teleost and mammalian...

recognized as a major endocrine organ, as it produces hormones such as leptin, estrogen, resistin, and cytokines (especially TNFα). In obesity, adipose...

to the discovery of leptin, she analyzed leptin concentrations of the mice in the parabiotic experiments. After injecting leptin into each pair's obese...

the brand name Myalept among others, is a synthetic analog of the hormone leptin used to treat various forms of dyslipidemia. It has been approved in Japan...

and leptin are released from the stomach and adipose cells, respectively, into the blood stream. Ghrelin stimulates feelings of hunger, whereas leptin stimulates...

disease Hypotonia-cystinuria syndrome Kleine–Levin syndrome Leptin deficiency or dysfunction Leptin receptor deficiency Luscan-lumish syndrome Macrosomia adiposa...

excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model of type II diabetes...

environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity). However, it accounts for...

mutations in the leptin gene in humans with obesity. On the contrary, leptin expression was increased, proposing the possibility of leptin-resistance in...

the face). This condition is also characterized by a lack of circulating leptin which may lead to osteosclerosis. The absence of fat tissue is associated...

leptin has been observed as a growth factor in breast tissue. Increased leptin levels have been observed in some cases of PT. The increase in leptin levels...

high concentrations of the ghrelin hormone. The hormones peptide YY and leptin can have an opposite effect on the appetite, causing the sensation of being...

hormones, myokines and adipokines (i.e. leptin and adiponectin) in human physiology and pathophysiology. Leptin has subsequently been approved by the Food...

functional leptin or who produce leptin but are insensitive to it are prone to develop obesity. This has been confirmed by experimental "knockdown" of leptin receptors...

part by leptin. Leptin inhibits the NPY/AgRP group while stimulating the POMC/CART group. Thus a deficiency in leptin signaling, either via leptin deficiency...

Investigator of the Howard Hughes Medical Institute. His discovery of the hormone leptin and its role in regulating body weight has had a major role in the area...

mutations in the leptin gene in humans with obesity. On the contrary Leptin expression was increased proposing the possibility of Leptin-resistance in human...

is an endocrine organ that secretes numerous protein hormones, including leptin, adiponectin, and resistin. These hormones generally influence energy metabolism...

about the body's energy state. They may be stimulated by signals such as leptin, alpha-MSH, and catecholamines; and inhibited by glucocorticoids, neuropeptide...

modulating leptin's actions outside of waking hours, may contribute to the restoration of leptin sensitivity during daytime, thereby counteracting leptin resistance...

All hormones secreted by the pituitary gland are peptide hormones, as are leptin from adipocytes, ghrelin from the stomach, and insulin from the pancreas...

Leptin might be the cause of the GnRH rise. Leptin has receptors in the hypothalamus which synthesizes GnRH. Individuals who are deficient in leptin fail...

secrete many proteins acting as adipokines such as resistin, adiponectin, leptin and apelin. An average human adult has 30 billion fat cells with a weight...

mechanisms, ranging from hormonal regulation to neural signaling. Ghrelin, leptin, and peptide YY are among the hormones involved in appetite control. Additionally...

Hany A.; AL-Biati, Haedar A (2022). "The Role of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio in Obesogenesis". Medical and Pharmaceutical...

citation needed] There are two hormones, leptin and ghrelin, that are important in appetite control. Leptin, released by adipose tissue, is a hormone...

extreme over-exercising found in most anorexia nervosa patients. Leptin and ghrelin: leptin is a hormone produced primarily by the fat cells in the body;...